Patents by Inventor Raphael Sole

Raphael Sole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing 1,6:2,3-dianhydro-?-D-mannopyranose
    Patent number: 8742077
    Abstract: The invention relates to a method for preparing 1,6:2,3-dianhydro-â-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound C, where R is an alykyl group and R? is an activating agent, in an alcohol/alcoholate mixture under anhydrous conditions.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: June 3, 2014
    Assignee: Sanofi
    Inventors: Pierre Jean Grossi, Christian Hoff, Jean-Claude Rovera, Raphael Sole
  • METHOD FOR PREPARING N-SUCCINIMIDYL N-BIOTINYL-6-AMINOCAPROATE
    Publication number: 20120232262
    Abstract: The invention relates to a method for preparing N-succinimidyl N-biotinyl-6-aminocaproate, characterised in that said method includes a step of activating N-biotinyl-6-aminocaproic acid in the form of a mixed anhydride, followed by coupling said mixed anhydride with N-hydroxysuccinimide.
    Type: Application
    Filed: November 19, 2010
    Publication date: September 13, 2012
    Applicant: SANOFI
    Inventors: Pierre Potier, Raphael Sole, Patrick Trouilleux
  • METHOD FOR PREPARING 1,6:2,3-DIANHYDRO-BETA-D-MANNOPYRANOSE
    Publication number: 20110213141
    Abstract: The invention relates to a method for preparing 1,6:2,3-dianhydro-â-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound C, where R is an alykyl group and R? is an activating agent, in an alcohol/alcoholate mixture under anhydrous conditions.
    Type: Application
    Filed: September 15, 2009
    Publication date: September 1, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Pierre Jean Grossi, Christian Hoff, Jean-Claude Rovera, Raphael Sole
  • Method for preparing N-aminopiperidine and its salts
    Patent number: 7951952
    Abstract: The invention concerns a novel method for preparing N-aminopiperidine of formula (I):
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: May 31, 2011
    Assignee: Sanofi-Aventis
    Inventors: Pierre Jean Grossi, Raphael Sole
  • METHOD FOR PREPARING N-AMINOPIPERIDINE AND ITS SALTS
    Publication number: 20080306274
    Abstract: The invention concerns a novel method for preparing N-aminopiperidine of formula (I):
    Type: Application
    Filed: June 30, 2008
    Publication date: December 11, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Pierre Jean GROSSI, Raphael SOLE
  • Method for the preparation of N-piperidino-1, 5-diphenylpyrazole-3-carboxamide derivatives
    Patent number: 7462632
    Abstract: A process for the preparation of for the preparation of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide and of its salts, wherein 1,5-dibromopentane is reacted with a compound of formula (IIIa) in the presence of Na2CO3 in acetonitrile heated at reflux.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: December 9, 2008
    Assignee: Sanofi-Aventis
    Inventors: Philippe Vayron, Marc Daumas, Raphael Sole, Alain Dlubala
  • METHOD FOR THE PREPARATION OF N-PIPERIDINO-1, 5-DIPHENYLPYRAZOLE-3-CARBOXAMIDE DERIVATIVES
    Publication number: 20080119653
    Abstract: A process for the preparation of for the preparation of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide and of its salts, wherein 1,5-dibromopentane is reacted with a compound of formula (IIIa) in the presence of Na2CO3 in acetonitrile heated at reflux.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 22, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Philippe VAYRON, Marc DAUMAS, Raphael SOLE, Alain DLUBALA
  • METHOD FOR PREPARING N-AMINOPIPERIDINE AND ITS SALTS
    Publication number: 20070173648
    Abstract: The invention concerns a novel method for preparing N-aminopiperidine of formula (I):
    Type: Application
    Filed: January 22, 2007
    Publication date: July 26, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Pierre Jean GROSSI, Raphael SOLE
  • Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate, its preparation and pharmaceutical compositions in which it is present
    Patent number: 5739381
    Abstract: The present invention relates to disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate.The invention further relates to the method of preparing this monohydrate.The invention further relates to the pharmaceutical compositions in which disodium tiludronate monohydrate is present as the active principle.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: April 14, 1998
    Assignee: Sanofi
    Inventors: Michel Bonnery, Michel Bouisset, Raphael Sole
  • Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate, its preparation and pharmaceutical compositions in which it is present
    Patent number: 5405994
    Abstract: The present invention relates to disodium 4-chlorophenylmethylenebisphosphonate monohydrate. The invention also relates to a method of preparing this form of the monohydrate, as well as to pharmaceutical compositions in which disodium tiludronate monohydrate is present as the active principle.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: April 11, 1995
    Assignee: Sanofi
    Inventors: Michel Bonnery, Michel Bouisset, Raphael Sole