Patents by Inventor Raphaele Clement
Raphaele Clement has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12203539Abstract: An accessory gearbox houses at least one gear train with a series of pinions. The casing has two substantially flat and opposite parallel side walls between which are mounted support shafts for each of the pinions, each of which receives accessories, and which define in the enclosure an internal volume surrounding a shaft supporting at least one hybridization pinion. The gearbox receives at least one electric machine having a rotor and a stator, wherein the rotor of the electric machine is supported by the shaft supporting the hybridization pinion of the gear train, and the stator extends around the rotor in the internal volume.Type: GrantFiled: September 20, 2023Date of Patent: January 21, 2025Assignee: SAFRAN TRANSMISSION SYSTEMSInventors: Clément Falguiere, Clément Romain Aimé Cadet, Florian Pierre-Yves Chaput, Raphaël Clément Stéphane Martin
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Publication number: 20240258564Abstract: A solid electrolyte including zwitterionic compounds comprising zwitterionic molecules and/or charge neutral polymers with zwitterion pendants. A salt is distributed through the solid such that the solid conducts alkali metal ions obtained from the salt and the zwitterionic compounds each include zero or more amorphous regions and one or more crystalline regions characterized by (1) a presence of Bragg diffraction peaks in an X-ray diffraction measurement of the solid; and (2) the solid having an ion conductivity of at least 10?4 S/cm at a temperature of 50 degrees Celsius when a transport number for the alkali metal ions is at least 0.5 and a molar ratio of the salt to the zwitterionic units is 0.9. The electrolyte exhibits surprisingly high alkali metal ion conductivity and linear elastic modulus over a wide range of practically useful temperatures.Type: ApplicationFiled: April 12, 2022Publication date: August 1, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Seamus D. Jones, Yanqiao Chen, Peter Richardson, Raphaele Clement, Craig J. Hawker, Glenn H. Fredrickson, Rachel A. Segalman
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Publication number: 20240093773Abstract: An accessory gearbox houses at least one gear train with a series of pinions. The casing has two substantially flat and opposite parallel side walls between which are mounted support shafts for each of the pinions, each of which receives accessories, and which define in the enclosure an internal volume surrounding a shaft supporting at least one hybridization pinion. The gearbox receives at least one electric machine having a rotor and a stator, wherein the rotor of the electric machine is supported by the shaft supporting the hybridization pinion of the gear train, and the stator extends around the rotor in the internal volume.Type: ApplicationFiled: September 20, 2023Publication date: March 21, 2024Applicant: SAFRAN TRANSMISSION SYSTEMSInventors: Clément FALGUIERE, Clément Romain Aimé CADET, Florian Pierre-Yves CHAPUT, Raphaël Clément Stéphane MARTIN
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Patent number: 11738344Abstract: The invention relates to a method for ordering, sorting and/or focusing particles in a first microfluidic channel system, the method comprising the steps of i) providing for a first microfluidic channel comprising at least a first and a second inlet and a first outlet, ii) injecting a first fluid into the channel through said first inlet, iii) injecting a second fluid into the channel through said second inlet, wherein the viscosity of the first fluid is higher than the viscosity of the second fluid, such that the two fluids flow in a laminar fashion unmixed side by side, and one of the two fluids comprises the particles to be ordered, sorted and/or focused. The invention also relates to a microfluidic channel system for sorting different particles into one droplet.Type: GrantFiled: September 19, 2018Date of Patent: August 29, 2023Assignee: HIFIBIO SASInventors: Raphael Clément Li-Ming Doineau, Arnaud Reitz, Marcel Reichen
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Publication number: 20230194396Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.Type: ApplicationFiled: February 22, 2023Publication date: June 22, 2023Inventors: Marcel Reichen, Raphael Clément Li-ming Doineau, Sami Ellouze
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Patent number: 11592367Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.Type: GrantFiled: January 18, 2018Date of Patent: February 28, 2023Assignee: HIFIBIO SASInventors: Marcel Reichen, Raphael Clément Li-Ming Doineau, Sami Ellouze
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Patent number: 11525826Abstract: The present invention relates to the field of biological diagnosis in oncology. It relates to a method and apparatus for detecting and/or characterizing tumor cells by detecting one or more elements of the tumor cell secretome, in particular one or more peptides or proteins, and, in particular, one or more tumor markers. The invention also relates to detecting and/or characterizing droplets of tumor cells and their method of preparation.Type: GrantFiled: April 18, 2017Date of Patent: December 13, 2022Assignees: Chu Montpellier, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Centre National De La Recherche Scientifique, Université De Montpellier, Axlr, Satt Du Languedoc RoussillonInventors: Catherine Michèle Marilou Alix-Panabieres, Andrew David Griffiths, Raphaël Clément Li-Ming Doineau, Clément Nizak, Philippe Chi-Thanh Nghe, Jean-Marie Pierre Baudry, Elodie Michèle Christine Brient-Litzler, Klaus Eyer, Jérôme Bibette
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Publication number: 20210284805Abstract: A composition of matter useful in an electrolyte, comprising a polymer including: a repeat unit, the repeat unit including a backbone section; and a side chain attached to the backbone section, wherein the side chain includes a ligand moiety configured to ionically bond to a lithium ion. The polymer has a glass transition temperature (e.g., less than room temperature) wherein the polymer is in a solid state during operation of a lithium ion battery comprising an electrolyte including the polymer.Type: ApplicationFiled: March 3, 2021Publication date: September 16, 2021Applicant: The Regents of the University of CaliforniaInventors: Rachel A. Segalman, Craig J. Hawker, Raphaele Clement, Javier Read de Alaniz, Nicole Michenfelder-Schauser, Peter Richardson, Andrei Nikolaev, Caitlin Sample, Hengbin Wang
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Publication number: 20200338552Abstract: The present invention is directed to a fluidic interface for delivering a fluid into a microfluidic device, the interface comprising a chamber comprising a first accepting/delivering fluid opening and a second accepting/delivering fluid opening, each opening being positioned opposite to the other, wherein the diameter of the first accepting/delivering fluid opening is smaller than the internal diameter of the chamber and a tubing system connecting the first accepting/delivering fluid opening to a pressure source capable of generating positive or negative pressure. The interface is characterized in that the second accepting/delivering fluid opening is designed to mechanically limit its insertion into a receptacle of a microfluidic device to ensure a predetermined gap (H) between the second accepting/delivering fluid opening and a lower side of the receptacle of a microfluidic device.Type: ApplicationFiled: October 24, 2018Publication date: October 29, 2020Inventors: Steven Scherr, Colin J. H. Brenan, Michael J. Brenan, Marcel Reichen, Raphael Clement Li-Ming Doineau
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Publication number: 20200215545Abstract: The invention relates to a method for ordering, sorting and/or focusing particles in a first microfluidic channel system, the method comprising the steps of i) providing for a first microfluidic channel comprising at least a first and a second inlet and a first outlet, ii) injecting a first fluid into the channel through said first inlet, iii) injecting a second fluid into the channel through said second inlet, wherein the viscosity of the first fluid is higher than the viscosity of the second fluid, such that the two fluids flow in a laminar fashion unmixed side by side, and one of the two fluids comprises the particles to be ordered, sorted and/or focused. The invention also relates to a microfluidic channel system for sorting different particles into one droplet.Type: ApplicationFiled: September 19, 2018Publication date: July 9, 2020Inventors: Raphael Clément Li-Ming Doineau, Arnaud Reitz, Marcel Reichen
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Publication number: 20190376879Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.Type: ApplicationFiled: January 18, 2018Publication date: December 12, 2019Inventors: Marcel Reichen, Raphael Clément Li-Ming Doineau, Sami Ellouze
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Patent number: 10416168Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.Type: GrantFiled: October 15, 2015Date of Patent: September 17, 2019Assignee: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Andrew David Griffiths, Raphaël Clément Li-Ming Doineau, Clément Nizak, Philippe Chi-Thanh Nghe, Jean Marie Pierre Baudry, Elodie Michéle Christine Brient-Litzler, Alexei Godina
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Publication number: 20190170741Abstract: The present invention relates to the field of biological diagnosis in oncology. It relates to a method and apparatus for detecting and/or characterizing tumor cells by detecting one or more elements of the tumor cell secretome, in particular one or more peptides or proteins, and, in particular, one or more tumor markers. The invention also relates to detecting and/or characterizing droplets of tumor cells and their method of preparation.Type: ApplicationFiled: April 18, 2017Publication date: June 6, 2019Inventors: Catherine Michèle Marilou ALIX - PANABIERES, Andrew David GRIFFITHS, Raphaël Clément Li-Ming DOINEAU, Clément NIZAK, Philippe Chi-Thanh NGHE, Jean-Marie Pierre BAUDRY, Elodie Michèle Christine BRIENT-LITZLER, Klaus EYER, Jérôme BIBETTE
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Publication number: 20170307626Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.Type: ApplicationFiled: October 15, 2015Publication date: October 26, 2017Inventors: Andrew David GRIFFITHS, Raphaël Clément Li-Ming DOINEAU, Clément NIZAK, Philippe Chi-Thanh NGHE, Jean Marie Pierre BAUDRY, Elodie Michèle Christine BRIENT-LITZLER