Patents by Inventor Raphaele Clement

Raphaele Clement has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12203539
    Abstract: An accessory gearbox houses at least one gear train with a series of pinions. The casing has two substantially flat and opposite parallel side walls between which are mounted support shafts for each of the pinions, each of which receives accessories, and which define in the enclosure an internal volume surrounding a shaft supporting at least one hybridization pinion. The gearbox receives at least one electric machine having a rotor and a stator, wherein the rotor of the electric machine is supported by the shaft supporting the hybridization pinion of the gear train, and the stator extends around the rotor in the internal volume.
    Type: Grant
    Filed: September 20, 2023
    Date of Patent: January 21, 2025
    Assignee: SAFRAN TRANSMISSION SYSTEMS
    Inventors: Clément Falguiere, Clément Romain Aimé Cadet, Florian Pierre-Yves Chaput, Raphaël Clément Stéphane Martin
  • Publication number: 20240258564
    Abstract: A solid electrolyte including zwitterionic compounds comprising zwitterionic molecules and/or charge neutral polymers with zwitterion pendants. A salt is distributed through the solid such that the solid conducts alkali metal ions obtained from the salt and the zwitterionic compounds each include zero or more amorphous regions and one or more crystalline regions characterized by (1) a presence of Bragg diffraction peaks in an X-ray diffraction measurement of the solid; and (2) the solid having an ion conductivity of at least 10?4 S/cm at a temperature of 50 degrees Celsius when a transport number for the alkali metal ions is at least 0.5 and a molar ratio of the salt to the zwitterionic units is 0.9. The electrolyte exhibits surprisingly high alkali metal ion conductivity and linear elastic modulus over a wide range of practically useful temperatures.
    Type: Application
    Filed: April 12, 2022
    Publication date: August 1, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Seamus D. Jones, Yanqiao Chen, Peter Richardson, Raphaele Clement, Craig J. Hawker, Glenn H. Fredrickson, Rachel A. Segalman
  • Publication number: 20240093773
    Abstract: An accessory gearbox houses at least one gear train with a series of pinions. The casing has two substantially flat and opposite parallel side walls between which are mounted support shafts for each of the pinions, each of which receives accessories, and which define in the enclosure an internal volume surrounding a shaft supporting at least one hybridization pinion. The gearbox receives at least one electric machine having a rotor and a stator, wherein the rotor of the electric machine is supported by the shaft supporting the hybridization pinion of the gear train, and the stator extends around the rotor in the internal volume.
    Type: Application
    Filed: September 20, 2023
    Publication date: March 21, 2024
    Applicant: SAFRAN TRANSMISSION SYSTEMS
    Inventors: Clément FALGUIERE, Clément Romain Aimé CADET, Florian Pierre-Yves CHAPUT, Raphaël Clément Stéphane MARTIN
  • Patent number: 11738344
    Abstract: The invention relates to a method for ordering, sorting and/or focusing particles in a first microfluidic channel system, the method comprising the steps of i) providing for a first microfluidic channel comprising at least a first and a second inlet and a first outlet, ii) injecting a first fluid into the channel through said first inlet, iii) injecting a second fluid into the channel through said second inlet, wherein the viscosity of the first fluid is higher than the viscosity of the second fluid, such that the two fluids flow in a laminar fashion unmixed side by side, and one of the two fluids comprises the particles to be ordered, sorted and/or focused. The invention also relates to a microfluidic channel system for sorting different particles into one droplet.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: August 29, 2023
    Assignee: HIFIBIO SAS
    Inventors: Raphael Clément Li-Ming Doineau, Arnaud Reitz, Marcel Reichen
  • Publication number: 20230194396
    Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 22, 2023
    Inventors: Marcel Reichen, Raphael Clément Li-ming Doineau, Sami Ellouze
  • Patent number: 11592367
    Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: February 28, 2023
    Assignee: HIFIBIO SAS
    Inventors: Marcel Reichen, Raphael Clément Li-Ming Doineau, Sami Ellouze
  • Patent number: 11525826
    Abstract: The present invention relates to the field of biological diagnosis in oncology. It relates to a method and apparatus for detecting and/or characterizing tumor cells by detecting one or more elements of the tumor cell secretome, in particular one or more peptides or proteins, and, in particular, one or more tumor markers. The invention also relates to detecting and/or characterizing droplets of tumor cells and their method of preparation.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 13, 2022
    Assignees: Chu Montpellier, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Centre National De La Recherche Scientifique, Université De Montpellier, Axlr, Satt Du Languedoc Roussillon
    Inventors: Catherine Michèle Marilou Alix-Panabieres, Andrew David Griffiths, Raphaël Clément Li-Ming Doineau, Clément Nizak, Philippe Chi-Thanh Nghe, Jean-Marie Pierre Baudry, Elodie Michèle Christine Brient-Litzler, Klaus Eyer, Jérôme Bibette
  • Publication number: 20210284805
    Abstract: A composition of matter useful in an electrolyte, comprising a polymer including: a repeat unit, the repeat unit including a backbone section; and a side chain attached to the backbone section, wherein the side chain includes a ligand moiety configured to ionically bond to a lithium ion. The polymer has a glass transition temperature (e.g., less than room temperature) wherein the polymer is in a solid state during operation of a lithium ion battery comprising an electrolyte including the polymer.
    Type: Application
    Filed: March 3, 2021
    Publication date: September 16, 2021
    Applicant: The Regents of the University of California
    Inventors: Rachel A. Segalman, Craig J. Hawker, Raphaele Clement, Javier Read de Alaniz, Nicole Michenfelder-Schauser, Peter Richardson, Andrei Nikolaev, Caitlin Sample, Hengbin Wang
  • Publication number: 20200338552
    Abstract: The present invention is directed to a fluidic interface for delivering a fluid into a microfluidic device, the interface comprising a chamber comprising a first accepting/delivering fluid opening and a second accepting/delivering fluid opening, each opening being positioned opposite to the other, wherein the diameter of the first accepting/delivering fluid opening is smaller than the internal diameter of the chamber and a tubing system connecting the first accepting/delivering fluid opening to a pressure source capable of generating positive or negative pressure. The interface is characterized in that the second accepting/delivering fluid opening is designed to mechanically limit its insertion into a receptacle of a microfluidic device to ensure a predetermined gap (H) between the second accepting/delivering fluid opening and a lower side of the receptacle of a microfluidic device.
    Type: Application
    Filed: October 24, 2018
    Publication date: October 29, 2020
    Inventors: Steven Scherr, Colin J. H. Brenan, Michael J. Brenan, Marcel Reichen, Raphael Clement Li-Ming Doineau
  • Publication number: 20200215545
    Abstract: The invention relates to a method for ordering, sorting and/or focusing particles in a first microfluidic channel system, the method comprising the steps of i) providing for a first microfluidic channel comprising at least a first and a second inlet and a first outlet, ii) injecting a first fluid into the channel through said first inlet, iii) injecting a second fluid into the channel through said second inlet, wherein the viscosity of the first fluid is higher than the viscosity of the second fluid, such that the two fluids flow in a laminar fashion unmixed side by side, and one of the two fluids comprises the particles to be ordered, sorted and/or focused. The invention also relates to a microfluidic channel system for sorting different particles into one droplet.
    Type: Application
    Filed: September 19, 2018
    Publication date: July 9, 2020
    Inventors: Raphael Clément Li-Ming Doineau, Arnaud Reitz, Marcel Reichen
  • Publication number: 20190376879
    Abstract: The present invention relates to a method for analyzing and selecting a specific droplet among a plurality of droplets (4), comprising the following steps: —providing a plurality of droplets (4), —for a droplet (4) among the plurality of droplets, measuring at least two optical signals, each optical signal being representative of a light intensity spatial distribution in the droplet for an associated wavelength channel, —calculating a plurality of parameters from the optical signals, —determining a sorting class for a droplet according to calculated parameters, —sorting said droplet according to its sorting class, wherein the plurality of parameters comprises the coordinates of a maximum for each optical signal and a co-localization parameter and the at least two calculated parameters used for the determining step comprises the co-localization parameter.
    Type: Application
    Filed: January 18, 2018
    Publication date: December 12, 2019
    Inventors: Marcel Reichen, Raphael Clément Li-Ming Doineau, Sami Ellouze
  • Patent number: 10416168
    Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: September 17, 2019
    Assignee: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Andrew David Griffiths, Raphaël Clément Li-Ming Doineau, Clément Nizak, Philippe Chi-Thanh Nghe, Jean Marie Pierre Baudry, Elodie Michéle Christine Brient-Litzler, Alexei Godina
  • Publication number: 20190170741
    Abstract: The present invention relates to the field of biological diagnosis in oncology. It relates to a method and apparatus for detecting and/or characterizing tumor cells by detecting one or more elements of the tumor cell secretome, in particular one or more peptides or proteins, and, in particular, one or more tumor markers. The invention also relates to detecting and/or characterizing droplets of tumor cells and their method of preparation.
    Type: Application
    Filed: April 18, 2017
    Publication date: June 6, 2019
    Inventors: Catherine Michèle Marilou ALIX - PANABIERES, Andrew David GRIFFITHS, Raphaël Clément Li-Ming DOINEAU, Clément NIZAK, Philippe Chi-Thanh NGHE, Jean-Marie Pierre BAUDRY, Elodie Michèle Christine BRIENT-LITZLER, Klaus EYER, Jérôme BIBETTE
  • Publication number: 20170307626
    Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.
    Type: Application
    Filed: October 15, 2015
    Publication date: October 26, 2017
    Inventors: Andrew David GRIFFITHS, Raphaël Clément Li-Ming DOINEAU, Clément NIZAK, Philippe Chi-Thanh NGHE, Jean Marie Pierre BAUDRY, Elodie Michèle Christine BRIENT-LITZLER