Patents by Inventor Raphaele Gerber

Raphaele Gerber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROFLUIDIC METHOD AND SYSTEM FOR ENZYME INHIBITION ACTIVITY SCREENING
    Publication number: 20150211045
    Abstract: Methods for screening a compound for enzyme inhibition activity include providing at least one sample mixture to a microfluidic device, applying vacuum pressure to the sample mixture, flowing the sample mixture along a microchannel of the microfluidic device, separating at least two components of the sample mixture based upon a net charge difference between the product and at least one other material to produce separated material, detecting at least one of the separated materials, and determining enzyme inhibition activity based on the detection of the separated material. Kits for screening a compound for enzyme inhibition activity include a first multiwell plate having a specific plurality of enzymes disposed within a first plurality of wells and a second multiwell plate having a plurality of enzyme substrates disposed with a second plurality of wells, a phosphate source and a cofactor disposed within each well of the second plate.
    Type: Application
    Filed: April 9, 2015
    Publication date: July 30, 2015
    Inventors: Jude A. Dunne, Javier A. Farinas, Irina G. Kazakova, Esther Huang, Raphaele Gerber, Roger Dettloff, Thi Ngoc Vy Trinh, Coleen Hacker
  • Microfluidic method and system for enzyme inhibition activity screening
    Publication number: 20090118139
    Abstract: Methods for screening a compound for enzyme inhibition activity include providing at least one sample mixture to a microfluidic device, applying vacuum pressure to the sample mixture, flowing the sample mixture along a microchannel of the microfluidic device, separating at least two components of the sample mixture based upon a net charge difference between the product and at least one other material to produce separated material, detecting at least one of the separated materials, and determining enzyme inhibition activity based on the detection of the separated material. Kits for screening a compound for enzyme inhibition activity include a first multiwell plate having a specific plurality of enzymes disposed within a first plurality of wells and a second multiwell plate having a plurality of enzyme substrates disposed with a second plurality of wells, a phosphate source and a cofactor disposed within each well of the second plate.
    Type: Application
    Filed: September 5, 2007
    Publication date: May 7, 2009
    Applicant: Caliper Life Sciences, Inc.
    Inventors: Jude A. Dunne, Javier A. Farinas, Irina G. Kazakova, Raphaele Gerber, Coleen Hacker, Roger Dettloff, Esther Huang, Thi Ngoc Vy Trinh