Patents by Inventor Raquel Hernandez

Raquel Hernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Flavivirus host range mutations and uses thereof
    Patent number: 10081795
    Abstract: Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: September 25, 2018
    Assignees: Research Development Foundation, Arbovax, Inc.
    Inventors: Dennis T. Brown, Raquel Hernandez, Malcolm E. Thomas, Katherine M. Smith
  • ATTENUATED ZIKA VIRUS CONSTRUCTS AND USES THEREOF
    Publication number: 20170296646
    Abstract: Novel attenuating deletions of Zika virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions that comprise the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Zika virus infection.
    Type: Application
    Filed: March 28, 2017
    Publication date: October 19, 2017
    Inventors: Raquel HERNANDEZ, Dennis T. BROWN
  • Attenuated Chikungunya virus
    Patent number: 9701719
    Abstract: Novel attenuating deletions of Chikungunya virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Chikungunya virus infection.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: July 11, 2017
    Assignee: Research Development Foundation
    Inventors: Dennis T. Brown, Raquel Hernandez
  • Methods and compositions for dengue virus 3 (DV3) infectious clone
    Patent number: 8895028
    Abstract: The present invention provides a nucleic acid molecule comprising a nucleotide sequence encoding an infectious RNA molecule encoding a live viral strain of a dengue 3 virus (DV3), wherein said nucleotide sequence is the nucleotide sequence of SEQ ID NO:1 or a nucleotide sequence having at least 99% identity with the nucleotide sequence of SEQ ID NO.1.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: November 25, 2014
    Assignee: Arbovax, Inc.
    Inventors: Katherine M. Smith, Raquel Hernandez
  • Flavivirus host-range mutations and uses thereof
    Patent number: 8889148
    Abstract: Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: November 18, 2014
    Assignee: Research Development Foundation
    Inventors: Dennis T. Brown, Raquel Hernandez
  • ATTENUATED CHIKUNGUNYA VIRUS
    Publication number: 20140086953
    Abstract: Novel attenuating deletions of Chikungunya virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Chikungunya virus infection.
    Type: Application
    Filed: September 26, 2013
    Publication date: March 27, 2014
    Applicant: Research Development Foundation
    Inventors: Dennis T. BROWN, Raquel HERNANDEZ
  • Methods and Compositions for Dengue Virus 3 (DV3) Infectious Clone
    Publication number: 20140024081
    Abstract: The present invention provides a nucleic acid molecule comprising a nucleotide sequence encoding an infectious RNA molecule encoding a live viral strain of a dengue 3 virus (DV3), wherein said nucleotide sequence is the nucleotide sequence of SEQ ID NO:1 or a nucleotide sequence having at least 99% identity with the nucleotide sequence of SEQ ID NO.1.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 23, 2014
    Applicant: ARBOVAX, INC.
    Inventors: KATHERINE M. SMITH, RAQUEL HERNANDEZ
  • FLAVIVIRUS HOST-RANGE MUTATIONS AND USES THEREOF
    Publication number: 20120003255
    Abstract: Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 5, 2012
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Dennis T. Brown, Raquel Hernandez
  • FLAVIVIRUS HOST RANGE MUTATIONS AND USES THEREOF
    Publication number: 20110236421
    Abstract: Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
    Type: Application
    Filed: March 23, 2011
    Publication date: September 29, 2011
    Inventors: DENNIS T. BROWN, Raquel Hernandez, Malcolm E. Thomas, Katherine M. Smith, Kavita Nanda