Patents by Inventor Raquel Maria Sanches

Raquel Maria Sanches has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
    Publication number: 20160362664
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: August 25, 2016
    Publication date: December 15, 2016
    Applicant: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Modified polymerases for improved incorporation of nucleotide analogues
    Patent number: 9447389
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: September 20, 2016
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • METHODS AND COMPOSITIONS FOR PREPARING NUCLEIC ACID LIBRARIES
    Publication number: 20160265027
    Abstract: Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries. Some embodiments include preparing libraries from nucleic acids obtained from degraded samples, such as ancient samples and fixed samples.
    Type: Application
    Filed: October 16, 2014
    Publication date: September 15, 2016
    Applicant: Illumina, Inc.
    Inventors: Raquel Maria Sanches-Kuiper, Vincent Peter Smith, Sean Humphray
  • Polymerases
    Publication number: 20160115461
    Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
    Type: Application
    Filed: December 1, 2015
    Publication date: April 28, 2016
    Applicant: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, Roberto Rigatti, Tobias William Barr Ost, Shankar Balasubramanian, Raquel Maria Sanches-Kuiper
  • Polymerases
    Patent number: 9273352
    Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 1, 2016
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, Roberto Rigatti, Tobias William Barr Ost, Shankar Balasubramanian, Raquel Maria Sanches-Kuiper
  • MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
    Publication number: 20150024463
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: September 3, 2014
    Publication date: January 22, 2015
    Applicant: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Modified polymerases for improved incorporation of nucleotide analogues
    Patent number: 8852910
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: October 7, 2014
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Hardold Swerdlow, David James Earnshaw
  • Polymerases
    Publication number: 20140287415
    Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
    Type: Application
    Filed: December 20, 2013
    Publication date: September 25, 2014
    Applicant: ILLUMINA, INC.
    Inventors: Geoffrey Paul Smith, Roberto Rigatti, Tobias William Barr Ost, Shankar Balasubramanian, Raquel Maria Sanches-Kuiper
  • Polymerases
    Patent number: 8623628
    Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: January 7, 2014
    Assignee: Illumina, Inc.
    Inventors: Tobias William Barr Ost, Geoffrey Paul Smith, Shankar Balasubramanian, Roberto Rigatti, Raquel Maria Sanches
  • Modified polymerases for improved incorporation of nucleotide analogues
    Publication number: 20130244302
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: April 4, 2013
    Publication date: September 19, 2013
    Applicant: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches, Hardold Swerdlow, David James Earnshaw
  • Modified polymerases for improved incorporation of nucleotide analogues
    Patent number: 8460910
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: June 11, 2013
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches, Harold Swerdlow, David James Earnshaw