Patents by Inventor Rasappa G. Arumugham
Rasappa G. Arumugham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9125847Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: GrantFiled: February 14, 2012Date of Patent: September 8, 2015Assignees: Janssen Sciences Ireland UC, Wyeth LLCInventors: Rasappa G. Arumugham, A. Krishna Prasad, Michael Hagen
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Patent number: 9095536Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: GrantFiled: August 20, 2007Date of Patent: August 4, 2015Assignees: Janssen Sciences Ireland UC, Wyeth LLCInventors: Rasappa G. Arumugham, A. Krishna Prasad, Michael Hagen
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Patent number: 9089510Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: GrantFiled: July 7, 2011Date of Patent: July 28, 2015Assignees: Janssen Sciences Ireland UC, Wyeth LLCInventors: Rasappa G. Arumugham, A. Krishna Prasad, Michael Hagen
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Publication number: 20120207706Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: ApplicationFiled: February 14, 2012Publication date: August 16, 2012Applicants: Wyeth LLC, Janssen Alzheimer ImmunotherapyInventors: Rasappa G. Arumugham, A. Krishna Prasad
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Patent number: 8227403Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: GrantFiled: December 17, 2004Date of Patent: July 24, 2012Assignees: Wyeth LLC, Janssen Alzheimer ImmunotherapyInventors: Rasappa G. Arumugham, A. Krishna Prasad, Michael Hagen
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Publication number: 20110287042Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: ApplicationFiled: July 7, 2011Publication date: November 24, 2011Applicants: Wyeth LLC, Janssen Alzheimer ImmunotherapyInventors: Rasappa G. Arumugham, A. Krishna Prasad
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Publication number: 20080299074Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: ApplicationFiled: August 20, 2007Publication date: December 4, 2008Applicants: Elan Pharmaceuticals, Inc., WyethInventors: Rasappa G. Arumugham, A. Krishna Prasad
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Publication number: 20080145373Abstract: The present invention is directed to methods of producing conjugates of A? peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.Type: ApplicationFiled: August 20, 2007Publication date: June 19, 2008Applicants: Elan Pharmaceuticals, Inc., WyethInventors: Rasappa G. Arumugham, A. Krishna Prasad
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Publication number: 20040052804Abstract: Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein said conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of said lipopolysaccharide, said conjugate eliciting a cross reactive immune response against heterologous strains of said gram negative bacteria.Type: ApplicationFiled: August 19, 2003Publication date: March 18, 2004Applicant: Wyeth Holdings CorporationInventors: Rasappa G. Arumugham, Maria Fortuna-Nevin, Michael A. Apicella, Bradford W. Gibson
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Patent number: 6645503Abstract: Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of the lipopolysaccharide, the conjugate eliciting a cross reactive immune response against heterologous strains of the gram negative bacteria.Type: GrantFiled: March 9, 1999Date of Patent: November 11, 2003Assignee: Wyeth Holdings CorporationInventors: Rasappa G. Arumugham, Maria Fortuna-Nevin, Michael A. Apicella, Bradford W. Gibson