Abstract: Disclosed is system and method for determining treatment effect in a clinical trial, the system comprising a server arrangement communicably coupled to a database arrangement. The server arrangement is configured to receive a plurality of datasets corresponding to a plurality of subjects from the database arrangement, wherein the plurality of subjects comprises a first set of subjects undergoing treatment and a second set of subjects receiving placebo, and wherein the plurality of datasets comprises of plurality independent variables and at least one dependent variables for the plurality of subjects. The system is configured to impute one or more values in the plurality of datasets to generate an imputed dataset of the plurality of subjects, wherein the imputed dataset comprises of imputed and non-imputed values corresponding to the plurality of independent variables and the at least one dependent variable.