Patents by Inventor Rati Verma

Rati Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of target protein activity through modifier proteins
    Patent number: 7291494
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: November 6, 2007
    Assignees: California Institute of Technology, National Institutes of Health
    Inventors: Gregory Cope, Rati Verma, Lakshminarayanan Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio
  • Modulation of COP9 signalsome isopeptidase activity
    Patent number: 7279317
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: October 9, 2007
    Assignee: California Institute of Technology
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio
  • Proteasome pathway inhibitors and related methods
    Publication number: 20050203063
    Abstract: The disclosure provides compositions and methods for blocking the proteasome pathway, as well as compounds that block mitotic cell cycle progression. Compounds disclosed include a family of molecules that bind to a multiubiquitin chain attached to a protein and thereby inhibit degradation of that protein by the proteasome pathway. According to another aspect of the disclosure, compounds are provided that inhibit cell cycle progression. Compounds disclosed herein may be formulated for pharmaceutical use and employed in methods for treating cancers or other hyperproliferative disorders.
    Type: Application
    Filed: September 13, 2004
    Publication date: September 15, 2005
    Inventors: Raymond Deshaies, Randall King, Rati Verma
  • Regulation of target protein activity through modifier proteins
    Patent number: 6846663
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: January 25, 2005
    Assignee: California Institute of Technology
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope
  • Regulation of target protein activity through modifier proteins
    Publication number: 20040259193
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: November 25, 2003
    Publication date: December 23, 2004
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope
  • Regulation of target protein activity through modifier proteins
    Publication number: 20030166243
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g. isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: January 14, 2002
    Publication date: September 4, 2003
    Inventors: Gregory Cope, Rati Verma, L. Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio
  • Modulation of COP9 signalsome isopeptidase activity
    Publication number: 20030153097
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Application
    Filed: January 9, 2003
    Publication date: August 14, 2003
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio
  • Regulation of target protein activity through modifier proteins
    Publication number: 20020156012
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: January 14, 2002
    Publication date: October 24, 2002
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope