Abstract: Multi-strain probiotic formulation for ameliorating and preventing symptoms of treatment resistant depression The current invention more specifically relates to methods and compositions comprising a multi-strain probiotic formulation that can be used for alleviating symptoms of treatment-resistant depression in humans. The multi-strain probiotic formulation disclosed herein for use as treatment for treatment-resistant depression symptoms comprises Bacillus coagulans, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium breve, and Bifidobacterium infantis. More specifically, the multi-strain probiotic formulation comprises Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, Bifidobacterium breve UBBr-01, and Bifidobacterium infantis UBBI-01.

Abstract: The current invention discloses the use of a multi-strain probiotic formulation comprising one or more novel Lactobacilli, Bifidobacterium and Bacillus strains for the alleviation, prevention and treatment of obsessive-compulsive disorder and/or obsessive-compulsive disorder like symptoms. The multi-strain probiotic formulation disclosed herein for use as treatment for obsessive-compulsive disorder symptoms comprises Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, Bifidobacterium breve UBBr-01, and Bifidobacterium infantis UBBI-01.

Abstract: The current invention discloses the method of treating, preventing and/or ameliorating Inflammatory Bowel Disease in patients by administering a probiotic composition comprising Bacillus clausii. The current invention discloses a method for, prevention and/or treatment, and amelioration of symptoms of Inflammatory Bowel Disease by use of Bacillus clausii, which modulates the microbiome in the gastro-intestinal tract and decreases inflammation in the patients.

Abstract: The current invention more specifically relates to methods of amelioration of symptoms of anxiety and depression by using a probiotic formulation comprising Bacillus coagulans. The probiotic formulation used for the amelioration of depression and anxiety symptoms may comprise a novel strain of Bacillus coagulans (Unique IS-2) (MTCC 5260, ATCC PTA-11748), which is used for treating, preventing or ameliorating at least one symptom of anxiety, stress, depression or a depressive disorder. The current invention discloses a method for treating, preventing or ameliorating at least one symptom of depression or a depressive disorder, the method comprising the step of administering to a subject an effective dosage regimen of a probiotic formulation comprising Bacillus coagulans.

Abstract: The current invention discloses a probiotic formulation comprising a prebiotic and the Lactobacilli strains Lactobacillus crispatus UBLcP-01, Lactobacillus gasseri UBLG-36, and Lactobacillus johnsonii UBLJ-01 strains. The current invention also encompasses methods for treating, ameliorating and/or preventing vaginitis caused by infections and inflammatory conditions, using the probiotic formulation described herein.

Abstract: Stress is any demand placed on the brain or physical body, thereby leading to anxiety and depression and it is a common phenomenon experienced by humans and animals. Stress, anxiety and depression often leads to serious mental ill health. People with anxiety disorders respond to certain things or situations with fear and dread and display physical signs such as a pounding heart and sweating. Often, people lose their willpower, concentration and interest in day to day activities, are drained of energy and can even become devoid of any emotion. It is documented that low activity of certain neurotransmitters can result in anxiety, chronic stress, depression, difficulty in concentrating, memory problems, muscle pain, headaches, insomnia and sleep problems. Therefore, if the level of these neurotransmitters is raised, the problem of stress, anxiety and depression can be cured.