Patents by Inventor Ratnakar B. Mujumdar
Ratnakar B. Mujumdar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8148539Abstract: Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10.Type: GrantFiled: July 1, 2010Date of Patent: April 3, 2012Assignees: GE Healthcare UK Limited, Carnegie Mellon UniversityInventors: Richard M. West, Nigel Bosworth, Ratnakar B. Mujumdar
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Patent number: 7964361Abstract: Disclosed are analogues of trimethine cyanine dyes, which are useful for importing fluorescent properties to target materials by covalent and non-covalent association.Type: GrantFiled: May 15, 2007Date of Patent: June 21, 2011Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Publication number: 20100267937Abstract: Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10.Type: ApplicationFiled: July 1, 2010Publication date: October 21, 2010Inventors: Richard M. West, Nigel Bosworth, Ratnakar B. Mujumdar
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Patent number: 7750163Abstract: Disclosed are cyanine dyes that are useful for labeling and detecting biological and other materials. The dyes are of formula (I) in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10.Type: GrantFiled: October 29, 2004Date of Patent: July 6, 2010Assignees: GE Healthcare U.K. Limited, Carnegie Mellon UniversityInventors: Richard M. West, Nigel Bosworth, Ratnakar B. Mujumdar
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Publication number: 20090281279Abstract: Disclosed are analogues of trimethine cyanine dyes, which are useful for importing fluorescent properties to target materials by covalent and non-covalent association.Type: ApplicationFiled: May 15, 2007Publication date: November 12, 2009Applicant: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Patent number: 7408062Abstract: Disclosed are analogues of trimethine cyanine dyes, which are useful for importing fluorescent properties to target materials by covalent and non-covalent association.Type: GrantFiled: January 27, 2003Date of Patent: August 5, 2008Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Patent number: 6686145Abstract: Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association.Type: GrantFiled: July 25, 2000Date of Patent: February 3, 2004Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Patent number: 6673943Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: GrantFiled: November 20, 2002Date of Patent: January 6, 2004Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Publication number: 20030224391Abstract: Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association.Type: ApplicationFiled: January 27, 2003Publication date: December 4, 2003Applicant: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Publication number: 20030220502Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: ApplicationFiled: November 20, 2002Publication date: November 27, 2003Inventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Patent number: 6545164Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: GrantFiled: October 7, 1999Date of Patent: April 8, 2003Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Patent number: 6479303Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: GrantFiled: September 11, 1998Date of Patent: November 12, 2002Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Patent number: 6277984Abstract: Fluorescent monomethine cyanine complexes rigidized a two-carbon alkyl group between the nitrogen's of the cyanine's heterocycles are provided and having the structure wherein R1 through R7 represent various selected groups or ring structures that may be chosen to provide desired solubility, reactive, or spectral properties.Type: GrantFiled: February 11, 1999Date of Patent: August 21, 2001Assignee: Carnegie Mellon UniversityInventors: Ratnakar B. Mujumdar, Alan S. Waggoner, Bhalchandra M. Karandikar
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Patent number: 6207464Abstract: Boron complexes of certain bis-heterocyclic compounds are provided. The complexes resemble monomethine cyanines and are useful for imparting fluorescent properties to materials by covalent and noncovalent association. The compounds have the following general formula: wherein the dotted lines Z1 and Z2 represent the atoms necessary to complete a structure selected from the group consisting of one ring, two fused rings, and three fused rings, each said ring having five or six atoms, and each said ring comprising carbon atoms and, optionally, no more than two atoms selected from oxygen, nitrogen and sulfur, and R1 through R5 represent various atoms or groups and M is Cl or F.Type: GrantFiled: August 28, 1998Date of Patent: March 27, 2001Assignee: Carnegie Mellon UniversityInventors: Bhalchandra M. Karandikar, Alan S. Waggoner, Ratnakar B. Mujumdar
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Patent number: 6133445Abstract: Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association. The compounds have the following general formula: ##STR1## optionally substituted by groups R.sup.2 -R.sup.9 wherein groups R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are attached to the rings containing X and Y or, optionally are attached to atoms of the Z.sup.a and Z.sup.b ring structures and groups R.sup.1 -R.sup.9 are chosen to provide desired solubility, reactivity and spectral properties to the fluorescent compounds;A is selected from O, S and NR.sup.11 where R.sup.11 is the substituted amino radical: ##STR2## where R' is selected from hydrogen, a C.sub.1-4 alkyl and aryl and R" is selected from C.sub.1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms, and a thiocarbamoyl radical; Z.sup.a and Z.sup.Type: GrantFiled: December 16, 1998Date of Patent: October 17, 2000Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Ratnakar B. Mujumdar
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Patent number: 6130094Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: GrantFiled: September 11, 1998Date of Patent: October 10, 2000Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Patent number: 6008373Abstract: The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials.Type: GrantFiled: June 7, 1995Date of Patent: December 28, 1999Assignee: Carnegie Mellon UniversityInventors: Alan S. Waggoner, Swati R. Mujumdar, Ratnakar B. Mujumdar
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Patent number: 5986093Abstract: Fluorescent monomethine cyanine complexes rigidized by a two-carbon alkyl group between the nitrogen's of the cyanine's heterocycles are provided and have the structure ##STR1## wherein R.sub.1 through R.sub.7 represent various selected groups or ring structures that may be chosen to provide desired solubility, reactive, or spectral properties.Type: GrantFiled: June 7, 1995Date of Patent: November 16, 1999Assignee: Carnegie Mellon UniversityInventors: Ratnakar B. Mujumdar, Alan S. Waggoner, Bhalchandra M. Karandikar
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Patent number: 5981747Abstract: Fluorescent monomethine cyanine complexes rigidized by a two-carbon alkyl group between the nitrogen's of the cyanine's heterocycles are provided and have the structure ##STR1## wherein R.sub.1 through R.sub.7 represent various selected groups or ring structures that may be chosen to provide desired solubility, reactive, or spectral properties.Type: GrantFiled: December 23, 1997Date of Patent: November 9, 1999Assignee: Carnegie Mellon UniversityInventors: Ratnakar B. Mujumdar, Alan S. Waggoner, Bhalchandra M. Karandikar
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Patent number: 5852191Abstract: Boron complexes of certain bis-heterocyclic compounds are provided. The complexes resemble monomethine cyanines and are useful for imparting fluorescent properties to materials by covalent and noncovalent association. The compounds have the following general formula: ##STR1## wherein the dotted lines Z.sub.1 and Z.sub.2 represent the atoms necessary to complete a structure selected from the group consisting of one ring, two fused rings, and three fused rings, each said ring having five or six atoms, and each said ring comprising carbon atoms and, optionally, no more than two atoms selected from oxygen, nitrogen and sulfur, and R.sub.1 through R.sub.5 represent various atoms or groups and M is Cl or F.Type: GrantFiled: June 7, 1995Date of Patent: December 22, 1998Assignee: Carnegie Mellon UniversityInventors: Bhalchandra M. Karandikar, Alan S. Waggoner, Ratnakar B. Mujumdar