Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.

Abstract: An implantable medical device including a radially-expandable body and an attached detection device. The detection device includes a sensor positioned on a surface of the radially-expandable body and configured to detect endothelialization of the surface. The detection device also includes a transmitter and a receiver. Systems incorporating the implantable medical device and methods of using the device are also disclosed.

Abstract: The disclosure presents an apparatus and method for measuring viscosity of a lubricating oil. The apparatus has a piezo-resistive cantilever sensor for sensing a first oil viscosity parameter. The sensor has a cantilever having a pressure receiving portion for receiving pressure exerted by the lubricating oil as the lubricating oil comes into contact with the pressure receiving portion. The cantilever also has first and second resistive portions in electrical communication with a first lead and a second lead, respectively, which are in electrical communication with an electrical circuit amplification element, for creating an output signal indicative of a change in the resistive characteristics of the first and second resistive portions of the cantilever as the lubricating oil comes into contact with the pressure receiving portion. The output signal can be used for determining oil viscosity.

Abstract: An implantable medical device including a radially-expandable body and an attached detection device. The detection device includes a sensor positioned on a surface of the radially-expandable body and configured to detect endothelialization of the surface. The detection device also includes a transmitter and a receiver. Systems incorporating the implantable medical device and methods of using the device are also disclosed.

Abstract: The disclosure presents an apparatus and method for measuring viscosity of a lubricating oil. The apparatus has a piezo-resistive cantilever sensor for sensing a first oil viscosity parameter. The sensor has a cantilever having a pressure receiving portion for receiving pressure exerted by the lubricating oil as the lubricating oil comes into contact with the pressure receiving portion. The cantilever also has first and second resistive portions in electrical communication with a first lead and a second lead, respectively, which are in electrical communication with an electrical circuit amplification element, for creating an output signal indicative of a change in the resistive characteristics of the first and second resistive portions of the cantilever as the lubricating oil comes into contact with the pressure receiving portion. The output signal can be used for determining oil viscosity.

Abstract: This invention provides a sensor to measure physical and/or chemical properties of viscous fluids. The sensor is based on microfabricated piezoresistive cantilevers. Deflection of these cantilevers is read out using, e.g., a wheatstone bridge to amplify and convert the deflection into a voltage output. The cantilevers and/or tips attached thereto, can be chemically or physically modified using reagents specific to interact with analytes to be detected in the fluid. The cantilevers can be integrated in a microfluidic system for easy fluid handling and the ability to manage small quantities of fluids.

Abstract: The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the membrane AbP channels. The invention further relates to screening and identifying therapeutically relevant compounds for treating Alzheimer's disease and other disorders.

Abstract: This invention provides a device and methods for the rapid detection and/or diagnosis and/or characterization of one or more allergies (e.g., causes IgE mediated allergic reaction (immediate hypersensitvity) in a mammal (e.g., a human or a non-human mammal). In certain embodiments, the device comprises a microcantilever array where different cantilevers comprising the array bear different antigens. Binding of IgE to the antigen on a cantilever causes bending of the cantilever which can be readily detected.