Patents by Inventor Ratnesh S. Joshi

Ratnesh S. Joshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDROPHOBIC INTERACTION CHROMATOGRAPHY FOR PURIFICATION OF OLIGONUCLEOTIDES
    Publication number: 20250011357
    Abstract: The present invention is directed to a method of purifying oligonucleotides using hydrophobic interaction chromatography.
    Type: Application
    Filed: June 13, 2024
    Publication date: January 9, 2025
    Inventors: Robert S. Gronke, Ratnesh S. Joshi
  • HYDROPHOBIC INTERACTION CHROMATOGRAPHY FOR PURIFICATION OF OLIGONUCLEOTIDES
    Publication number: 20210269467
    Abstract: The present invention is directed to a method of purifying oligonucleotides using hydrophobic interaction chromatography.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 2, 2021
    Inventors: Robert S. Gronke, Ratnesh S. Joshi
  • Hydrophobic interaction chromatography for purification of oligonucleotides
    Patent number: 10947262
    Abstract: The invention herein describes a method to purify a target oligonucleotide using hydrophobic interaction chromatography (HIC). The method includes adding a salt to a mixture of the target oligonucleotide and product-related impurities, applying the diluted mixture, at a particular dynamic loading capacity, to the hydrophobic interaction chromatography resin (or hydrophobic adsorbent), washing the hydrophobic adsorbent with an aqueous salt solution, eluting the target oligonucleotide with a eluting solution, and collecting the eluent comprising the target oligonucleotide.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: March 16, 2021
    Assignee: BIOGEN MA INC.
    Inventors: Robert S. Gronke, Ratnesh S. Joshi
  • HYDROPHOBIC INTERACTION CHROMATOGRAPHY FOR PURIFICATION OF OLIGONUCLEOTIDES
    Publication number: 20190248823
    Abstract: The present invention is directed to a method of purifying oligonucleotides hydrophobic interaction chromatography.
    Type: Application
    Filed: June 13, 2017
    Publication date: August 15, 2019
    Inventors: Robert S. Gronke, Ratnesh S. Joshi