Patents by Inventor Raul Cabrera

Raul Cabrera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11340189
    Abstract: The enzyme telomerase is present at about 85% of human cancers that makes it not only an excellent target for cancer treatment but also an excellent marker for cancer detection. Using a single stranded DNA probe specific for telomerase binding and reverse transcription tethered to an interdigital gold electrode array surface, the chromosome protection provided by the telomerase was replicated and followed by Electrochemical Impedance Spectroscopy as an unlabeled biosensor. Using a custom system, which is simple and affordable, the impedance measurements were taken while incubating at 37° C. and promoting the probe elongation. This resulted in up to 14-fold increase in the charge transfer resistance when testing a telomerase-positive nuclear extract from Jurkat cells compared to the heat-inactivated telomerase-negative nuclear extract.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 24, 2022
    Assignee: University of Puerto Rico
    Inventors: Carlos Raul Cabrera, Lisandro Federico Cunei, Carlos I. Gonzalez, Marina Martinez-Vargas
  • Publication number: 20180252663
    Abstract: The enzyme telomerase is present at about 85% of human cancers that makes it not only an excellent target for cancer treatment but also an excellent marker for cancer detection. Using a single stranded DNA probe specific for telomerase binding and reverse transcription tethered to an interdigital gold electrode array surface, the chromosome protection provided by the telomerase was replicated and followed by Electrochemical Impedance Spectroscopy as an unlabeled biosensor. Using a custom system, which is simple and affordable, the impedance measurements were taken while incubating at 37° C. and promoting the probe elongation. This resulted in up to 14-fold increase in the charge transfer resistance when testing a telomerase-positive nuclear extract from Jurkat cells compared to the heat-inactivated telomerase-negative nuclear extract.
    Type: Application
    Filed: November 30, 2015
    Publication date: September 6, 2018
    Inventors: Carlos Raul Cabrera, Lisandro Federico Cunci, Carlos I. Gonzalez, Maria Martinez-Vargas
  • Patent number: 6123359
    Abstract: The present invention relates to an inflator for a vehicle airbag employing non-azide gas generants. The invention also relates to a new filter system for airbag inflators. The filter is a metal ribbon coiled within the inflator house. The metal ribbon comprises at least one segment of apertures and a segment of expanded metal.
    Type: Grant
    Filed: July 25, 1998
    Date of Patent: September 26, 2000
    Assignee: Breed Automotive Technology, Inc.
    Inventors: Raul Cabrera, Cezary Grzelczyk
  • Patent number: 6065774
    Abstract: A new filtration system for gas generators, especially side impact airbag inflators for use in automobiles, has a sheet of expanded metal formed into a tube, cylinder or other geometric form and a bed of expanded metal chips. The interior of the geometric form is filled with chips of expanded metal and this configuration has been found extremely effective in cooling and filtering the gases produced during the combustion of a gas generant. The filtration system disposed between the gas generant bed and the gas exit apertures of the inflator housing. The weight of the filtration system should be at least four times the weight of the gas generant placed in the inflator housing.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: May 23, 2000
    Assignee: Breed Automotive Technology, Inc.
    Inventor: Raul Cabrera
  • Patent number: 5985060
    Abstract: The present invention relates to improved non-azide gas generants and methods for their manufacture for use in an automobile gas bag system. This discovery overcomes the problems of moisture and thermal cycling in a non-azide gas generant pellet through the use of at least two fuels selected from guanidine nitrate, nitroguanidine, triaminoguanidine nitrate, diaminoguanidine nitrate and monoguanidine nitrate and an oxidizer system comprising mixtures of strontium nitrate, sodium nitrate and ammonium perchlorate.
    Type: Grant
    Filed: July 25, 1998
    Date of Patent: November 16, 1999
    Assignee: Breed Automotive Technology, Inc.
    Inventors: Raul Cabrera, Cezary Grzelczyk