Patents by Inventor Raul E. Vizcardo

Raul E. Vizcardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro generation of thymic organoid from human pluripotent stem cells
    Patent number: 11898166
    Abstract: Disclosed are methods of preparing thymic organoids according to embodiments of the invention. Also disclosed are methods of preparing thymic emigrant cells in vitro, according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e g., cancer.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: February 13, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Raul E. Vizcardo, Nicholas P. Restifo
  • PREFERENTIAL GENERATION OF iPSC CARRYING ANTIGEN SPECIFIC TCRs FROM TUMOR INFILTRATING LYMPHOCYTES
    Publication number: 20230265508
    Abstract: Disclosed are methods for reprogramming cancer-reactive T cells into iPSC cells as well as methods utilizing such cells for the identification of cancer-antigen specific TCRs and the treatment of cancer.
    Type: Application
    Filed: August 20, 2021
    Publication date: August 24, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Raul E. Vizcardo, SM Rafiqul Islam, Naritaka Tamaoki, Takuya Maeda, Nicholas P. Restifo
  • METHODS OF PRODUCING T CELL POPULATIONS USING INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20230036952
    Abstract: Provided are methods of producing an isolated population of T cells for adoptive cell therapy. Also provided are related isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer, infections, and autoimmune conditions in a patient.
    Type: Application
    Filed: January 7, 2021
    Publication date: February 2, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Meghan L. Good, Rafiqul SM Islam, Naritaka Tamaoki, Raul E. Vizcardo, Nicholas P. Restifo
  • METHODS FOR MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING REJUVENATED T CELLS
    Publication number: 20220162551
    Abstract: The present disclosure relates generally to methods of producing rejuvenated T cells, comprising, contacting T cells with at least one reprogramming factor and reactivating the contacted cells; and compositions and methods of using same. The present disclosure also describes cell populations prepared according to methods described herein. The disclosure also provides for methods of treating patients using cell populations prepared by the methods described herein.
    Type: Application
    Filed: November 23, 2021
    Publication date: May 26, 2022
    Inventors: Raul E. Vizcardo Sakoda, Nicholas Restifo, Richard D. Klausner, Yin Huang, Takuya Maeda, Naritaka Tamaoki, Yasuhiro Yamazaki
  • IN VITRO GENERATION OF THYMIC ORGANOID FROM HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20200270571
    Abstract: Disclosed are methods of preparing thymic organoids according to embodiments of the invention. Also disclosed are methods of preparing thymic emigrant cells in vitro, according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e g , cancer.
    Type: Application
    Filed: September 19, 2018
    Publication date: August 27, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Raul E. Vizcardo, Nicholas P. Restifo
  • METHODS OF PREPARING HEMATOPOIETIC PROGENITOR CELLS IN VITRO
    Publication number: 20200263136
    Abstract: Disclosed are methods of preparing CD34+CD43+ hematopoietic progenitor cells (HPC) in vitro according to embodiments of the invention. Also disclosed are methods of differentiating CD34+CD43+ hematopoietic progenitor cells to hematopoietic lineage cells according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e.g., cancer, according to embodiments of the invention.
    Type: Application
    Filed: November 8, 2018
    Publication date: August 20, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Raul E. Vizcardo, Naritaka Tamaoki, Meghan L. Good, Nicholas P. Restifo
  • METHODS OF PREPARING AN ISOLATED OR PURIFIED POPULATION OF THYMIC EMIGRANT CELLS AND METHODS OF TREATMENT USING SAME
    Publication number: 20200080057
    Abstract: Disclosed are methods of preparing thymic emigrant cells in vitro, isolated or purified thymic emigrant cells prepared by the methods, and pharmaceutical compositions comprising the same. Further disclosed are methods of treating or preventing a condition in a mammal comprising administering the thymic emigrant cells or pharmaceutical compositions comprising the same to the mammal.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 12, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Raul E. Vizcardo, Nicholas D. Klemen, Nicholas P. Restifo