Abstract: This application relates to a bifunctional compound having the structure of Formula (I): or a pharmaceutically acceptable salt, solvate, enantiomer, stereoisomer, or isotopic derivative thereof, which contains, on one end, a cereblon E3 ubiquitin ligase that binds to the E3 ubiquitin ligase and, on the other end, a moiety that binds the target protein, Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4), such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from cellular signaling mediated by the target protein are treated or prevented with bifunctional compounds and compositions of the present disclosure.

Abstract: Bifunctional compounds, which find utility as modulators of Kirsten ras sarcoma protein (KRas or KRAS), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the Von Hippel-Lindau E3 ubiquitin ligase and on the other end a moiety which binds KRas, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: A molded golf grip for a golf club includes first simulated wrap, and a second simulated wrap. The first simulated wrap includes a first wrap surface extending in a helical pattern. The first wrap surface includes a first wrap surface texture and a first wrap width that is less than a pitch of the helical pattern. The second simulated wrap includes a second wrap surface extending in a second helical pattern intertwined helically with the first wrap surface. The second wrap surface includes a second wrap surface texture that is different than the first wrap surface texture and a second wrap width that is less than the pitch. The first simulated wrap and the second simulated wrap are molded as a single body forming a shaft opening there within.

Abstract: A molded golf grip for a golf club includes first simulated wrap, and a second simulated wrap. The first simulated wrap includes a first wrap surface extending in a helical pattern. The first wrap surface includes a first wrap surface texture and a first wrap width that is less than a pitch of the helical pattern. The second simulated wrap includes a second wrap surface extending in a second helical pattern intertwined helically with the first wrap surface. The second wrap surface includes a second wrap surface texture that is different than the first wrap surface texture and a second wrap width that is less than the pitch. The first simulated wrap and the second simulated wrap are molded as a single body forming a shaft opening there within.

Abstract: A golf grip for a golf club includes a cap, a body, a tip, and a grip surface. The body includes an under layer, a top layer, and a middle layer. The under layer includes a first color. The top layer includes a second color, different than the first color. The top layer is disposed on the under layer. The middle layer includes a third material. The middle layer is at least partially disposed between the under layer and the top layer. The tip is a portion of the under layer extending beyond the top layer and the middle layer. The grip surface extends between the cap and the tip. The grip surface is the radially outer surface of the body and includes the top layer, a plurality of exposed portions of the under layer, and a plurality of exposed portions of the middle layer.

Abstract: A golf grip for a golf club includes a butt end, a tip end, a grip surface, and a gripping feature. The tip end includes a shaft opening. The grip surface extends between the butt end and the tip end. The grip surface is a tapered circular cylinder with an axis extending from the butt end to the tip end. The gripping feature includes a rake surface forming an acute angle with the grip surface. The rake surface extends into the grip at an acute angle relative to a plane perpendicular to the axis.

Abstract: A molded golf grip for a golf club includes first simulated wrap, and a second simulated wrap. The first simulated wrap includes a first wrap surface extending in a helical pattern. The first wrap surface includes a first wrap surface texture and a first wrap width that is less than a pitch of the helical pattern. The second simulated wrap includes a second wrap surface extending in a second helical pattern intertwined helically with the first wrap surface. The second wrap surface includes a second wrap surface texture that is different than the first wrap surface texture and a second wrap width that is less than the pitch. The first simulated wrap and the second simulated wrap are molded as a single body forming a shaft opening there within.

Abstract: A golf grip for a golf club includes a butt end, a tip end, a grip surface, and a gripping feature. The tip end includes a shaft opening. The grip surface extends between the butt end and the tip end. The grip surface is a tapered circular cylinder with an axis extending from the butt end to the tip end. The gripping feature includes a rake surface forming an acute angle with the grip surface. The rake surface extends into the grip at an acute angle relative to a plane perpendicular to the axis.

Abstract: A golf grip for a golf club includes a cap, a body, a tip, and a grip surface. The body includes an under layer, a top layer, and a middle layer. The under layer includes a first color. The top layer includes a second color, different than the first color. The top layer is disposed on the under layer. The middle layer includes a third material. The middle layer is at least partially disposed between the under layer and the top layer. The tip is a portion of the under layer extending beyond the top layer and the middle layer. The grip surface extends between the cap and the tip. The grip surface is the radially outer surface of the body and includes the top layer, a plurality of exposed portions of the under layer, and a plurality of exposed portions of the middle layer.

Abstract: A golf grip for a golf club includes a butt end, a tip end, a grip surface, and a gripping feature. The tip end includes a shaft opening. The grip surface extends between the butt end and the tip end. The grip surface is a tapered circular cylinder with an axis extending from the butt end to the tip end. The gripping feature includes a rake surface forming an acute angle with the grip surface. The rake surface extends into the grip at an acute angle relative to a plane perpendicular to the axis.

Abstract: The invention is directed to 6-(4-pyrimidinyl)-1H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1-R4 are defined herein. The compounds of the invention axe inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: Interactive videos are displayed to a user by adding annotations to a non-interactive video. During video playback, hotspots are displayed on a portion of the video that a viewer interacts with to access annotations relating to the hotspot. The hotspot indicates an element or object of the video that are interactable by the user. The annotation data and hotspot information is separately stored from the underlying video, enabling the annotation and hotspot information to be modified without editing the underlying video, and enabling the annotation to be accessed from a separate system from the location of the video. In this way, viewers can obtain additional data about any element, including, but not limited to, people, products, and places, appearing within the video at any moment, simply by clicking on a hotspot relating to these elements.

Abstract: The invention is directed to substituted indoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, and R3 are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, stroke, Type 1 diabetes Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to 6-(4-pyrimidinyl)-1H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1-R4 are defined herein. The compounds of the invention axe inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention.

Abstract: An interface converter module includes a metallized housing having a first end and a second end. A printed circuit board is mounted within the housing and has mounted thereon electronic circuitry configured to convert data signals from a host device transmission medium to the second transmission medium. The printed circuit board has not more than twenty contact fingers adhered at one end in order to form a host connector, a media connector is at the other end of the module. The media end having a dual LC duplex optical receptacle, where each duplex portion of the dual LC duplex optical receptacle houses a ROSA and a TOSA. The module and receiver may include interengaging rails and slots and/or keys and keyways to ensure correct matching of modules and receptacles.

Abstract: A pluggable transceiver module comprising a housing having a first side and a face perpendicular to the first side, and a tab extending beyond the surface of the first side, and the tab sized to mate with a slot in a receptacle of a host device for receiving the pluggable transceiver module housing; a member slidably mounted on the first side proximate the tab; a lever rotatably mounted on the housing, whereby rotating the lever causes the member to slide between the tab and the slot on the receptacle and remove the tab from within the slot, thereby releasing the pluggable transceiver module from the receptacle. The lever includes a free end and a rotatably mounted end, the rotatably mounted end including an extension adjacent to the member, such that extending the free end outward causes the extension to drive the member inward.