Patents by Inventor Raul Rapun

Raul Rapun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of digoxigenin
    Patent number: 3953431
    Abstract: Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1##Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amnio acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.
    Type: Grant
    Filed: September 28, 1973
    Date of Patent: April 27, 1976
    Assignee: Becton, Dickinson & Company
    Inventors: Herman Rutner, Raul Rapun, Nathan Lewin
  • Tritiated derivatives of cyclic nucleotides monophosphates
    Patent number: 3937698
    Abstract: Tritiated succinylated derivatives of cyclic nucleotides, in particular multitritiated succinylated cyclic adenosine monophosphate, useful in the radioimmunoassay of cyclic nucleotides, and maleyl derivatives of cyclic nucleotides useful in the production of the tritiated derivatives.
    Type: Grant
    Filed: July 27, 1973
    Date of Patent: February 10, 1976
    Assignee: Becton, Dickinson & Company
    Inventors: Sidney Gutcho, Raul Rapun, Herman Rutner, Andrew Charig