Patents by Inventor Raul Rolando Calvo

Raul Rolando Calvo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD206 Modulators Their Use and Methods for Preparation
    Publication number: 20230056497
    Abstract: Compounds of Formula I, Formula II, and Formula III and the pharmaceutically acceptable salts thereof are disclosed. The variables X, a, b, c, d, R1-4, R10-15 and R17-22 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving M2 phenotype of macrophages. Pharmaceutical compositions containing compounds of Formula I or Formula II or Formula III and methods of treatment comprising administering compounds of Formula I and Formula II and Formula III are also disclosed.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 23, 2023
    Inventors: Raul Rolando Calvo, Bolormaa Baljinnyam, Andres Eduardo Dulcey, Udo Rudloff, Mark James Henderson, Juan Jose Marugan, Xin Hu, Noel Terrence Southall, Rushikesh Vilas Sable
  • SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF
    Publication number: 20220315548
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a phenyl-sulfonic amide (or similar) structure which function as agonists of mucolipin 1 (ML1), and their use as therapeutics for the treatment of Duchenne muscular dystrophy (DMD) and related disorders.
    Type: Application
    Filed: August 28, 2020
    Publication date: October 6, 2022
    Inventors: Haoxing Xu, Lu Yu, Juan Jose Marugan, Raul Rolando Calvo, Natalia Julia Martinez, Noel Terrence Southall, Marc Ferrer, Xin Hu
  • Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders
    Patent number: 10239830
    Abstract: Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 26, 2019
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, The United States of America, as represented by the Secretary, Depart. of Health and Human Services
    Inventors: Samarjit Patnaik, Mercedes Taylor, Raul Rolando Calvo, Juan Jose Marugan, Noel Southall, Wei Zheng, Marc Ferrer-Alegre, Seameen Dehdasthi, Patricia Dranchak, Fannie Chen, Yiannis Ioannou
  • BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS
    Publication number: 20180044286
    Abstract: Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides.
    Type: Application
    Filed: February 11, 2016
    Publication date: February 15, 2018
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, and Human Services
    Inventors: Samarjit PATNAIK, Mercedes TAYLOR, Raul Rolando CALVO, Juan Jose MARUGAN, Noel SOUTHALL, Wei ZHENG, Marc FERRER-ALEGRE, Seameen DEHDASTHI, Patricia DRANCHAK, Fannie CHEN, Yiannis IOANNOU
  • Calcilytic compounds
    Patent number: 6395919
    Abstract: Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: May 28, 2002
    Assignees: SmithKline Beecham Corporation, NPS Pharmaceuticals
    Inventors: Pradip Kumar Bhatnagar, Joelle Lorraine Burgess, James Francis Callahan, Raul Rolando Calvo, Eric G. Del Mar, Maria Amparo Lago, Thomas The Nguyen
  • Calcilytic compounds
    Patent number: 6294531
    Abstract: Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: September 25, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert M. Barmore, Pradip Kumar Bhatnagar, William M. Bryan, Joelle Lorraine Burgess, James Francis Callahan, Raul Rolando Calvo, Eric G. Del Mar, Maria Amparo Lago, Thomas The Nguyen, Derek Sheehan, Robert Lawrence Smith, Linda Sue Southall, Bradford C. Van Wagenen
  • Fibrinogen receptor antagonists
    Patent number: 6069143
    Abstract: This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: May 30, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Fadia El-Fehail Ali, William Edward Bondinell, Raul Rolando Calvo, Thomas Wen-Fu Ku, William Henry Miller, James Samanen, Joseph Walter Venslavsky, Tobias Oregon Yellin