Abstract: The present invention relates to a heat exchanger for gases, in particular for the exhaust gases of an engine, which includes a plurality of gas circulation conduits and a casing for the exchange of heat between said gases and a coolant fluid that surrounds the gas circulation conduits housed inside the casing, wherein baffles are used to configure the passage of the coolant fluid between said gas circulation conduits, having at least one inlet baffle that directs the flow of coolant to the part and thus improving the operating conditions of the exchanger and making same more efficient.

Abstract: The present invention relates to a heat exchanger for gases, in particular for the exhaust gases of an engine, which includes a plurality of gas circulation conduits and a casing for the exchange of heat between said gases and a coolant fluid that surrounds the gas circulation conduits housed inside the casing, wherein baffles are used to configure the passage of the coolant fluid between said gas circulation conduits, having at least one inlet baffle that directs the flow of coolant to the part and thus improving the operating conditions of the exchanger and making same more efficient.

Abstract: Vegetable material coating subject to dehydration and oxidation, sugar cane buds or setts preferably, which involve a substrate, an agglutinant agent, a plasticizing agent, and a biodegradable film or coverage. Such substrate can be from commercial crops, earth, cellulose, corn shell or other cereals, perlome, bagasse, fertile earth, compost, sand, coconut fibre or other vegetable origin fibres, or their combinations. The agglutinant agent can be proteins, fat, vegetable gums, modified starch and/or starch gels, dextrins, maltodextrins, carboxymetylcellulose, cellulose, kitosane mixed with polyalcohols, pectin, agar, alginate, sorbitol or other polyalcohols, glycerides, such as fats and vegetable and animal oils, water-proofing agents, polymeric plasticizing agents, phosphates, acetyl monoglycerides, glycerol, gat acids, sorbitol or other polyalcohols.

Abstract: Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

Abstract: The present invention is related to the recombinant production of proteins by using a synthetic gene for high protein expression in Pichia pastoris. More specifically, the invention describes the production of Sm14 Schistosoma mansoni recombinant protein, where a synthetic gene was created to promote high expression of such protein, a gene which was cloned under control of two types of Pichia pastoris promoters: methanol-inducible promoter (AOXI) and constituent promoter (GAP). With these constructions, Pichia pastoris strains were genetically manipulated to efficiently produce vaccine antigen Sm14. The processes to produce and purify this protein from P. pastoris cells, which can be escalated for their industrial production, were also improved.

Abstract: Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

Abstract: Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

Abstract: A ground surface marking system including a beam transmitter configured to emit electromagnetic radiation and a distal target. The distal target is oriented to be impacted along a first target surface by at least a portion of the electromagnetic radiation. The distal target is mounted on a target stand configured for adjustment with respect to a vertical axis. The system also includes a target applicator having a second target surface, a base including a shaft, and a container attached to the base and configured to hold and dispense markers for placement along the ground surface extending between the beam transmitter and the distal target.

Abstract: The present invention relates to a vector for the expression of recombinant proteins, antigens, pathogen-like particles and immunogenic complexes, said vector (pMRKA vector) being produced by modifying the plasmids containing the gene sequence of the T7 promoter of E. coli, this modification being mainly characterized by the substitution of the ampicillin-resistance gene by the kanamycin-resistance gene, and by the insertion of the par sequence (partition sequence which determines the efficient segregation of the plasmids in daughter cells during cell division). Also provided are expression vectors based on the pMRKA plasmid, which additionally comprise at least one of the gene sequences of the exosome of P. abyssi, which vectors are designated pMRKA-EXO, pMRKA-RING and pSUMAC. The invention also provides the vectors additionally comprising gene sequences with immunomodulatory or immunoregulatory activity, preferably the pMRKA-Z-Z-EXO and pMRKA-Z-Z-RING vectors.

Abstract: The present invention relates to a complex of polyproteins containing immunogenic regions derived from the P36, P46, HSP, NrdF, P97, MHP271 e P216 antigens of M. hyopneumoniae, which regions are fused with segments of the Rrp4. Rrp41 and Rrp42 carrier proteins of P. abyssi, forming a single complex. The present invention further provide the following objects: (i) a gene coding the polyprotein complex, which complex is based on the exosome of P. abyssi and carries copies of vaccine antigens of M. hyopneumoniae; (ii) an antigenic composition comprising the polyprotein complex of the invention, optionally one or more auxiliary agents and/or additives and a pharmacologically acceptable excipient; (iii) a method for producing said polyprotein complex; and (iv) uses of said complex and composition in the treatment and prevention of disease caused by M. hyopneumoniae infection.

Abstract: The present invention provides a compound of perillic acid in the form of a salt, having Formula II, exhibiting anti-cancer activity, where counterion M+ comprises alkaline or alkaline earth metals, such as Na+ (sodium), K+ (potassium), Ca+2/2 (calcium), etc. The invention further discloses a method of obtaining the compound, a pharmaceutical composition, use of the compound and a method of treating cancer.

Abstract: Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

Abstract: A ground surface marking system including a beam transmitter configured to emit electromagnetic radiation and a distal target. The distal target is oriented to be impacted along a first target surface by at least a portion of the electromagnetic radiation. The distal target is mounted on a target stand configured for adjustment with respect to a vertical axis. The system also includes a target applicator having a second target surface, a base including a shaft, and a container attached to the base and configured to hold and dispense markers for placement along the ground surface extending between the beam transmitter and the distal target.

Abstract: A process for purification of a fatty acid binding proteins such as, e.g., Sm14 of Pichia pastoris or type-3 FABP protein of Fasciola hepatica. The process includes the steps of: (a) performing lysis of cells containing the fatty acid binding protein to obtain a lysate; (b) clarifying the lysate obtained in step (a) to obtain a clarified lysate; (c) loading the clarified lysate in a column containing an anion exchange resin; (d) eluting proteins from the column by pH changes in the column; and (e) separating contaminant proteins from the fatty acid binding protein by gel-filtration.

Abstract: A process for purification of a fatty acid binding proteins such as, e.g., Sm14 of Pichia pastoris or type-3 FABP protein of Fasciola hepatica. The process includes the steps of: (a) performing lysis of cells containing the fatty acid binding protein to obtain a lysate; (b) clarifying the lysate obtained in step (a) to obtain a clarified lysate; (c) loading the clarified lysate in a column containing an anion exchange resin; (d) eluting proteins from the column by pH changes in the column; and (e) separating contaminant proteins from the fatty acid binding protein by gel-filtration.

Abstract: The production of recombinant proteins using a synthetic gene for increased expression of the protein in Pichia pastoris is disclosed. More specifically, disclosed is a process for producing a recombinant Sm14 protein of Schistosoma mansoni, by providing a synthetic gene for increased production of Sm14 protein, producing the gene and genetically manipulating the Pichia pastoris strain with the gene in order to produce a vaccine effectively. Improved methods are also provided for producing and purifying this protein from P. pastoris cells, which can be scaled for industrial production.

Abstract: The present invention pertains to the field of production of recombinant proteins, using a synthetic gene for increased expression of the protein in Pichia pastoris. More specifically, the invention describes the production of a recombinant Sm14 protein of Schistosoma mansoni, by providing a synthetic gene for increased production of Sm14 protein, producing said gene and genetically manipulating the Pichia pastoris strain with said gene in order to produce a vaccine effectively. Improved methods are also provided for producing and purifying this protein from P. pastoris cells, which can be scaled for industrial production.

Abstract: The primary objective of the present invention is the development of new mutant forms of the Sm14 protein, for producing a greater production volume. The recombinant proteins here obtained were capable of providing protection against schistosome and fasciola infection. The level of protection of Sm14 recombinant proteins obtained in the present invention was similar to that reached in the parasite saline extract. The mutant proteins of the present invention have reached approximately 100% of renaturation after the heating at 80° C., different from wild forms of the Sm14 protein. Moreover, after storage for 2 months at 4° C., mutant proteins have shown smaller ?-structure loss than wild forms that have shown formation with random structure, as demonstrated by the circular dichroism analysis, indicating the success of mutations.