Patents by Inventor Raul Sanchez Gutierrez

Raul Sanchez Gutierrez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for cryopreservation of human spermatozoa free from seminal plasma using a fast and simple aseptic vitrification-devitrification process; portable kit for carrying out the method; and use of the same for treatment of disorders related to reproductive failures
    Patent number: 9005886
    Abstract: The present invention discloses a method for cryopreservation of human spermatozoa: the method comprises providing spermatozoa free from seminal liquid; mixing the spermatozoa with vitrification medium, wherein the main cryoprotectant agent is 0.1-0.3 M sucrose; placing the sample inside straws and rapidly freezing them; refrigerating the straws with no need of liquid N2; and devitrifying the sample in a medium of the present invention. The present invention furthermore discloses a portable kit that makes easy to implement the method, said kit comprising vitrification and devitrification solutions in the volumes required to develop the method and the physical support to carry out the same, i.e. the straws. The use of this kit is also disclosed for the treatment of disorders related to reproductive failures.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: April 14, 2015
    Assignees: Universidad de La Frontera, Universitaet Ulm
    Inventors: Raul Sanchez Gutierrez, Jennie Risopatron Gonzalez, Mabel Schulz Rubilar, Evgenia Isachenko, Vladimir Isachenko
  • Contraceptive peptides derived from the venom of the spider , nucleotide sequences to transform a microorganism to produce said peptides; methods to obtain the peptides; pharmaceutical compositions containing thereof and use thereof
    Patent number: 8980842
    Abstract: The present invention is directed to an active agent with contraceptive properties which corresponds to a peptide fragment of the Latrodectus mirabilisi's venom. The peptide generally includes the amino acid sequence of SEQ ID NO 2 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. Furthermore, a pharmaceutical contraceptive composition comprising the peptide fragment and one or more pharmaceutically acceptable vehicles is also described. The peptide fragment and pharmaceutical compositions are useful as a contraceptive and spermicide agent.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 17, 2015
    Assignees: Universidad de la Frontera, Universidad de Chile, Universidad Federal de Sao Paulo, Laboratorios Andromaco S.A.
    Inventors: Fernando Romero Mejia, Raúl Sanchez Gutierrez, Eduardo Bustos Obregón, Antonio De Miranda, Andrés Rudolphy Fontaine
  • METHOD FOR CRYOPRESERVATION OF HUMAN SPERMATOZOA FREE FROM SEMINAL PLASMA USING A FAST AND SIMPLE ASEPTIC VITRIFICATION-DEVITRIFICATION PROCESS; PORTABLE KIT FOR CARRYING OUT THE METHOD; AND USE OF THE SAME FOR TREATMENT OF DISORDERS RELATED TO REPRODUCTIVE FAILURES
    Publication number: 20130157250
    Abstract: The present invention discloses a method for cryopreservation of human spermatozoa: the method comprises providing spermatozoa free from seminal liquid; mixing the spermatozoa with vitrification medium, wherein the main cryoprotectant agent is 0.1-0.3 M sucrose; placing the sample inside straws and rapidly freezing them; refrigerating the straws with no need of liquid N2; and devitrifying the sample in a medium of the present invention. The present invention furthermore discloses a portable kit that makes easy to implement the method, said kit comprising vitrification and devitrification solutions in the volumes required to develop the method and the physical support to carry out the same, i.e. the straws. The use of this kit is also disclosed for the treatment of disorders related to reproductive failures.
    Type: Application
    Filed: February 16, 2011
    Publication date: June 20, 2013
    Applicants: UNIVERSITAET ULM, UNIVERSIDAD DE LA FRONTERA
    Inventors: Raul Sanchez Gutierrez, Jennie Risopatron Gonzalez, Mabel Schulz Rubilar, Evgenia Isachenko, Vladimir Isachenko
  • CONTRACEPTIVE PEPTIDES DERIVED FROM THE VENOM OF THE SPIDER Latrodectus mirabilis, NUCLEOTIDE SEQUENCES TO TRANSFORM A MICROORGANISM TO PRODUCE SAID PEPTIDES; METHODS TO OBTAIN THE PEPTIDES; PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF AND USE THEREOF
    Publication number: 20110237523
    Abstract: The present invention is directed to an active agent with contraceptive properties. Said active agent corresponds to a molecular fraction of the venom from the spider Latrodectus mirabilis. The active agent is a peptide with a sequence according to SEQ ID NO 1 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. In a preferred embodiment, the active agent with contraceptive properties is a peptide with 10 to 30 amino acids, preferably 20 amino acids. Said embodiment is exemplified by the sequence identified as SEQ ID NO 2 or sequences that are at least 85% similar, obtained by chemical synthesis or through recombinant DNA technologies. Furthermore, a method to obtain the contraceptive peptide is disclosed, said method comprising cloning the nucleotide sequence in a microorganism.
    Type: Application
    Filed: March 22, 2011
    Publication date: September 29, 2011
    Applicants: Universidad de la Frontera, Universidad de Chile, Universidad Federal de Sao Paulo, Laboratorios Andromaco S.A.
    Inventors: Fernando Romero Mejia, Raúl Sanchez Gutierrez, Eduardo Bustos Obregón, Antonio De Miranda, Andrés Rudolphy Fontaine