Patents by Inventor Ravi K. Varma

Ravi K. Varma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs
    Patent number: 4243608
    Abstract: Compounds having the formula ##STR1## and acid-addition salts thereof, wherein R is hydrogen or alkyl of 1 to 3 carbon atoms and n is 0,1,2,3 or 4 are useful reagents for derivatizing organic compounds to permit the radioiodination of those compounds and their use as tracers in radioimmunoassays, or to permit their use as haptens.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: January 6, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, B. Richard Vogt
  • Steroidal-17-spiro-dihydrofuranones
    Patent number: 4243586
    Abstract: Steroidal-17-spiro-dihydrofuranones, i.e., steroid having in the 17-position a group having the partial structural formula ##STR1## wherein R.sub.1 is bromine, chlorine, or fluorine; R.sub.2 is alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, .alpha.-methyl, .beta.-methyl, hydroxy or a conventional hydrolyzable ester thereof, have topical antiinflammatory activity.
    Type: Grant
    Filed: January 18, 1980
    Date of Patent: January 6, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sam T. Chao, Ravi K. Varma
  • Steroid derivatives and their use in radioimmunoassays
    Patent number: 4230621
    Abstract: Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: October 28, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • Steroid derivatives and their use in radioimmunoassays
    Patent number: 4221725
    Abstract: Radiolabeled steroid derivatives having the formula ##STR1## wherein St is des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.
    Type: Grant
    Filed: January 17, 1979
    Date of Patent: September 9, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • Process for preparing steroidal [16.alpha.,17-b]naphthaleno-21-carboxylic acid esters
    Patent number: 4219488
    Abstract: Steroidal [16.alpha.,17-b]naphthaleno-21-carboxylic acid esters can be prepared from 21-hydroxy-.DELTA..sup.16 -steroids by converting the starting steroid to a 21-carboxylic acid ester -.DELTA..sup.16 -steroid and then fusing the tetrahydronaphthalene ring to the 16,17-positions of the intermediate.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: August 26, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Process for preparing steroidal [16.alpha.,17-d]cyclohexene-21-carboxylic acid esters
    Patent number: 4213912
    Abstract: Steroidal [16.alpha., 17-d]cyclohexene-21-carboxylic acid esters can be prepared from 21-hydroxy-.DELTA..sup.16 -steroids by first converting the starting steroid to a 21-carboxylic acid ester -.DELTA..sup.16 -steroid and then fusing the cyclohexene ring to the 16,17-positions of the intermediate.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: July 22, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Vitamin B.sub.12 derivative suitable for radiolabeling
    Patent number: 4209614
    Abstract: Radiolabeled vitamin B.sub.12 derivatives having the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioassays.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: June 24, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jack Bernstein, Ravi K. Varma, B. Richard Vogt, Frank L. Weisenborn
  • Steroidal[16.alpha.,17-b]naphthaleno-21-carboxylic acid esters
    Patent number: 4164504
    Abstract: Steroids having the formula ##STR1## wherein R.sub.1 is alkyl, aryl, or arylalkyl; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, methyl or fluorine; R.sub.4 is chlorine, fluorine or hydroxy and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together are =0; R.sub.6 and R.sub.7 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR2## hydroxy, halogen, phenyl or cyano with the proviso that when R.sub.6 and R.sub.7 are different, one of R.sub.6 and R.sub.7 is hydrogen; R.sub.8 is hydrogen or ##STR3## wherein R.sub.9 and R.sub.10 are the same or different and are hydrogen or alkyl have useful antiinflammatory activity.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: August 14, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Steroidal[16.alpha.,17-d]cyclohexene-21-carboxylic acid esters
    Patent number: 4160772
    Abstract: Steroids having the formula ##STR1## wherein R.sub.1 is alkyl, aryl or arylalkyl; R.sub.2 and R.sub.3 are the same or different and are hydrogen, alkyl or aryl; R.sub.4 is hydrogen and R.sub.5 is hydroxy or together R.sub.4 and R.sub.5 are .dbd.O; and R.sub.6 is hydrogen, methyl or fluorine; have useful antiinflammatory activity.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: July 10, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Process for preparing D-homo oxasteroids
    Patent number: 4155917
    Abstract: A steroid having the formula ##STR1## or the 1,2-dehydro derivative thereof, can be prepared by reacting the corresponding steroid having the formula ##STR2## or the 1,2-dehydro derivative thereof, with ozone and an alkanol having the formula R.sub.3 --OH and then treating the reaction mixture with a reducing agent; wherein R'.sub.1 is hydrogen, acyloxy or halogen; R.sub.3 is alkyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; R.sub.6 is hydrogen, fluorine or methyl; and R.sub.7 is hydrogen, chlorine or bromine.
    Type: Grant
    Filed: June 15, 1978
    Date of Patent: May 22, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Christopher M. Cimarusti, Paul Grabowich, Ravi K. Varma
  • 17-Alkylthio (and arylthio) androsteno[17.alpha.,16.alpha.-b]benzopyran-3-ones and [16.alpha.,17.alpha.]naphthopyran-3-ones
    Patent number: 4146538
    Abstract: Steroids having the formula ##STR1## wherein X is -S-, ##STR2## R.sub.1 is alkyl, aryl or acyloxyalkyl; R.sub.2 is carbonyl or .beta.-hydroxymethylene; R.sub.3 is hydrogen or halogen; R.sub.4 is hydrogen, fluorine or methyl; R.sub.5 is hydrogen or alkyl; and R.sub.6 and R.sub.7 are the same or different and are hydrogen, halogen, alkyl or alkoxy, or R.sub.6 and R.sub.7 together with the benzene ring to which they are attached form a naphthalene group; can be used as antiinflammatory agents.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: March 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Sam T. Chao
  • 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
    Patent number: 4133811
    Abstract: Steroids having the formula ##STR1## wherein X is --S--, ##STR2## R.sub.1 is alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.3 is hydrogen, fluorine or methyl; can be used as antiinflammatory agents.
    Type: Grant
    Filed: February 17, 1978
    Date of Patent: January 9, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • D-Homo oxasteroids
    Patent number: 4116978
    Abstract: Steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R.sub.1 is hydrogen, acyloxy, halogen, or hydroxy; R.sub.2 is hydrogen or alkyl; R.sub.3 is alkyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; R.sub.6 is hydrogen, fluorine or methyl; and R.sub.7 is hydrogen, chlorine or bromine; can be used as antiinflammatory agents.
    Type: Grant
    Filed: July 20, 1977
    Date of Patent: September 26, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Christopher M. Cimarusti, Paul Grabowich, Ravi K. Varma
  • Steroidal[16.alpha.,17-b]benzodioxins
    Patent number: 4113722
    Abstract: Steroids having the formula ##STR1## wherein R.sub.1 is hydrogen, acyloxy, halogen or alkoxy of 1 to 10 carbons; R.sub.2 is halogen or cyano; R.sub.3 is hydrogen or halogen; R.sub.4 is carbonyl, .beta.-hydroxymethylene or .beta.-acetyloxymethylene; and R.sub.5 is hydrogen or fluorine; can be used as antiinflammatory agents.
    Type: Grant
    Filed: November 11, 1977
    Date of Patent: September 12, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Christopher M. Cimarusti
  • 17-Alkylthio (and arylthio) androsteno[16.alpha.,17.alpha.-b]benzodioxin-3-ones
    Patent number: 4094840
    Abstract: Steroids having the formula ##STR1## wherein X is --S--, ##STR2## R.sub.1 is alkyl, aryl, or acyloxyalkyl; the R.sub.2 groups are halogen; R.sub.3 is hydrogen or halogen; R.sub.4 is carbonyl, .beta.-hydroxymethylene or .beta.-acyloxymethylene; and R.sub.5 is hydrogen or fluoro; can be used as antiinflammatory agents.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: June 13, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 .alpha., 17 .alpha.-b]naphthalenes and derivatives
    Patent number: 4091036
    Abstract: pg,1 Steroids having the formula ##STR1## wherein X is ##STR2## R.sub.1 is alkyl, aryl or acyloxyalkyl; R.sub.2 and R.sub.3 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR3## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.2 and R.sub.3 are different, one of R.sub.2 and R.sub.3 is hydrogen; R.sub.4 is carbonyl, .beta.-hydroxymethylene or .beta.-acyloxymethylene; R.sub.5 is hydrogen or halogen; and R.sub.6 is hydrogen or fluorine; can be used as antiinflammatory agents.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: May 23, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Ravi K. Varma
  • Steroidal [16.alpha.,17-d]isoxazolidines
    Patent number: 4018774
    Abstract: Novel steroids having the structure ##STR1## and the 1,2-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, hydroxy, alkanoyloxy, fluorine, chlorine, or bromine; R.sub.2 is alkyl or aryl; R.sub.3 is alkyl, aryl, alkanoyl, aroyl, alkoxycarbonyl, or cyano; R.sub.4 is hydrogen, alkyl, or aryl; R.sub.5 is hydrogen, fluorine or methyl; R.sub.6 is carbonyl, .beta.-hydroxymethylene, or .beta.-chloromethylene; R.sub.7 is hydrogen or methyl; and R.sub.8 is fluorine or chlorine; have useful anti-inflammatory activity.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: April 19, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Christopher M. Cimarusti
  • Steroidal[16.alpha.,17-c][2H]pyrroles
    Patent number: 4018757
    Abstract: Steroids having the structure ##STR1## and the 1,2-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, hydroxy, ##STR2## fluorine, chlorine, or bromine; R.sub.2 is alkyl or aryl; R.sub.3 is aryl, cyano, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonyl, or arylsulfonyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; and R.sub.6 is hydrogen, fluorine, or methyl; have useful antiinflammatory activity.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: April 19, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Christopher M. Cimarusti
  • Steroidal 16.beta.-alkyl[16.alpha.,17-b]naphthalenes
    Patent number: 3994935
    Abstract: Novel steroids having the structure ##SPC1##And the 1,2-dehydro derivatives thereof, wherein R.sub.1 is chlorine, fluorine, or hydroxy and R'.sub.1 is hydrogen or R.sub.1 and R'.sub.1 together are =O; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, methyl, or fluorine; R.sub.4 is hydrogen, hydroxy, ##EQU1## or halogen; R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU2## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen; and R.sub.7 and R.sub.8 are the same or different and are hydrogen or alkyl.
    Type: Grant
    Filed: November 24, 1975
    Date of Patent: November 30, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Christopher M. Cimarusti
  • 1 H-androsta(16,17)cyclopentene-3-ones
    Patent number: 3979417
    Abstract: Steroids having the formula ##SPC1##And the 1,2-dehydro derivatives thereof, wherein R.sub.1 is phenyl, naphthyl, or substituted phenyl or naphthyl, have useful anti-inflammatory activity.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: September 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Christopher M. Cimarusti