Patents by Inventor Ravi Pathak

Ravi Pathak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190185818
    Abstract: Embodiments of the present disclosure concern systems, methods, and compositions for both in vitro and in vivo models of metastases, such as bone metastases. In specific embodiments, there is a system comprising a source of bone cells, such as osteoblasts, and a source of cancer cells, wherein the bone cells and cancer cells are configured in a chamber or on a chick chorioallantoic membrane such that interaction between the cells is determined. In specific embodiments, the bone cells are comprised in an organoid comprising both mesenchymal stem cells and osteoblasts (although a naturally derived bone scaffold may be employed), and the cancer cells are comprised in an organoid comprising mesenchymal stem cells and the cancer cells.
    Type: Application
    Filed: August 24, 2017
    Publication date: June 20, 2019
    Inventors: Andrew G. Sikora, Ravi Pathak, Rebeca San Martin, David R. Rowley
  • Publication number: 20190029235
    Abstract: Embodiments of the disclosure encompass systems that utilize chick chorioallantoic membranes (CAM) as models for cancer xenografts, including at least patient-derived xenografts (CAM-PDX). In particular embodiments, the system employs the CAM-PDX to graft and culture different types of tumor tissue on a single or multiple eggs. In specific embodiments multiple tumor regions of a single tumor are cultured on a single egg. Frozen tissue is successfully revived, in specific embodiments. Downstream applications following successful establishment of CAM-PDX models are encompassed.
    Type: Application
    Filed: November 4, 2016
    Publication date: January 31, 2019
    Inventors: Andrew G. Sikora, Ravi Pathak