Patents by Inventor Ravi S. Vinayak

Ravi S. Vinayak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Labelled oligonucleotides synthesized on solid-supports
    Patent number: 6835827
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure where S is a solid-support, A is a cleavable linker, X is a moiety with three or more attachment sites, L is a label, Y is a nucleophile, i.e. O, NH, NR or S, and P1 is an acid cleavable protecting group are provided. The labelled solid-support is reacted in a cyclical fashion to synthesize a labelled oligonucleotide on a solid-support in the 5′ to 3′ direction, having the structure: Labelled oligonucleotides are also synthesized by reacting: (i) a label reagent bearing functionality consisting of carboxylic acid, sulfonic acid, phosphonic acid, or phosphoric acid, (ii) an oligonucleotide on solid support with nucleophilic functionality, and (iii) a coupling reagent, whereby an ester, amide, thioester, sulfonamide, sulfonate, phosphonate, phosphoramidate, phosphorothioate, or phosphate bond is formed.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: December 28, 2004
    Assignee: Applera Corporation
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Labelled oligonucleotides synthesized on solid-supports
    Publication number: 20030191303
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure 1
    Type: Application
    Filed: February 20, 2003
    Publication date: October 9, 2003
    Applicant: Applera Corporation
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Multiple-labelled oligonucleotides synthesized on solid-supports
    Patent number: 6525183
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure where S is a solid-support, A is a cleavable linker, X is a moiety with three or more attachment sites, L is a label, Y is a nucleophile, i.e. O, NH, NR or S, and P1 is an acid cleavable protecting group are provided. The labelled solid-support is reacted in a cyclical fashion to synthesize a labelled oligonucleotide on a solid-support in the 5′ to 3′ direction, having the structure: Labelled oligonucleotides are also synthesized by reacting: (i) a label reagent bearing functionality consisting of carboxylic acid, sulfonic acid, phosphonic acid, or phosphoric acid, (ii) an oligonucleotide on solid support with nucleophilic functionality, and (iii) a coupling reagent, whereby an ester, amide, thioester, sulfonamide, sulfonate, phosphonate, phosphoramidate, phosphorothioate, or phosphate bond is formed.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: February 25, 2003
    Assignee: PE Corporation (NY)
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Multiple-labelled oligonucleotides synthesized on solid-supports
    Publication number: 20020165389
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure 1
    Type: Application
    Filed: November 7, 2001
    Publication date: November 7, 2002
    Applicant: PE Corporation (NY)
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
    Patent number: 6255476
    Abstract: Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure where S is a solid-support, A is a cleavable linker, X is a moiety with three or more attachment sites, L is a label, Y is a nucleophile, i.e. O, NH, NR or S, and P1 is an acid cleavable protecting group are provided. The labelled solid-support is reacted in a cyclical fashion to synthesize a labelled oligonucleotide on a solid-support in the 5′ to 3′ direction, having the structure: Labelled oligonucleotides are also synthesized by reacting: (i) a label reagent bearing functionality consisting of carboxylic acid, sulfonic acid, phosphonic acid, or phosphoric acid, (ii) an oligonucleotide on solid support with nucleophilic functionality, and (iii) a coupling reagent, whereby an ester, amide, thioester, sulfonamide, sulfonate, phosphonate, phosphoramidate, phosphorothioate, or phosphate bond is formed.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: July 3, 2001
    Assignee: PE Corporation (NY)
    Inventors: Ravi S. Vinayak, Linda G. Lee, Khairuzzaman B. Mullah, Barnett B. Rosenblum
  • Process and compounds for RNA synthesis
    Patent number: 5281701
    Abstract: A method and compositions are provided for synthesizing polynucleotides wherein the exocyclic amino groups of 5'-O-protected-2'O-alkylsilyl-adenosine phosphoramidite and 5'-O-protected-2'-O-alkylsilylguanosine phosphoramidite monomers are protected with dialkylformamidine. In a preferred embodiment, the ribonucleoside phosphoramidite monomers are activated with ethylthiotetrazole.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: January 25, 1994
    Assignee: Applied Biosystems, Inc.
    Inventor: Ravi S. Vinayak