Abstract: Methods, systems and computer program products provide a dynamically configurable 3D display utilizing a content receiver. The content receiver generates the 3D content with an offset that enables the images to be viewable in a plurality of 3D regions, where each 3D region and images therein are perceived as having a different degree of depth relative to other images within 3D regions. The user viewing the 3D content may interact with the 3D content through a sensor device communicatively coupled to the content receiver that senses user movements and transmits signals to the content receiver for taking some action in response to the user's movements, including moving the 3D content between various 3D regions. 3D content in a foreground 3D region may be partially transparent to enable viewing of underlying 3D content in a background 3D region. 3D content may include a 3D user interface enabling the user to enter selections.

Abstract: A radiographic imaging sub-system for treating neonates is disclosed. The subsystem includes a radiographic compatible incubator for providing a controlled environment for a neonate, a radiographic compatible RF coil selectively coupled to the incubator for providing radiographic imaging of the neonate, and a radiographic compatible trolley for transporting the incubator and the RF coil. Additionally, the sub-system can include a radiographic MR compatible vital signs monitor, a radiographic compatible infusion pump, a radiographic compatible injector, a radiographic compatible ventilator, a radiographic compatible blender, radiographic compatible intravenous pole, tanks, pressure reducers/gauges and flow pipes.

Abstract: An active, transdermal delivery system includes a support structure and a fluid reservoir within the support structure configured to contain a fluid to be delivered transdermally. There is also at least one exit orifice defined in the support structure that is in communication with the fluid reservoir. The orifice has a diameter of between about 1 ?m and 500 ?m. Furthermore, a repeatable activation means is disposed within the support structure and is in cooperation with the exit orifice for ejection of fluid in response to an activation signal.

Abstract: Described here are methods, devices, and kits for microjet drug delivery. The devices described here may be modular or non-modular. The modular devices typically include a first module having a drug reservoir and a nozzle in fluid communication with the drug reservoir and a second module having an actuator and a power supply. The power supply provides power to the actuator and when the first and second modules are coupled, the actuator is capable of acting on a dispensing member causing it to dispense a drug in liquid form from the drug reservoir via the nozzle at a velocity sufficient to penetrate skin. Other devices described include a nozzle, a reservoir in fluid communication with the nozzle, a dispensing member, and an actuator. In these devices, the nozzle has at least one feature that enhances nozzle contact with the skin in order to reduce lateral drug leakage about the nozzle.

Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.

Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

Abstract: A method and apparatus for performing jet injections using piezoelectric technology. A jet injector apparatus includes a reservoir having a variable capacity for holding a liquid to be delivered to a biological tissue via a jet injection. A nozzle is disposed at a first end of the reservoir with at least one opening for allowing the liquid to be expelled from the reservoir.

Abstract: A multi-tune radio frequency (RF) coil for concurrent magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) is disclosed. The multi-tune RF coil includes a first end ring having a generally annular opening and a first plurality of elongated segments coupled to and positioned circumferentially around the first end ring. The first plurality of elongated segments are azimuthally offset from one another by a substantially equal angular distance. A second RF coil includes a second end ring having a generally annular opening and a second plurality of elongated segments coupled to and positioned circumferentially around the second end ring. The second plurality of elongated segments are azimuthally offset from one another by a substantially equal angular distance.

Abstract: A fluid delivery system includes a reservoir, a delivery actuator, and at least one delivery nozzle of a microjet having an exit orifice with a diameter between about 1 ?m and about 500 ?m. The delivery actuator may be configured to deliver a quantity of fluid contained in the reservoir into tissue of an individual through the nozzle or nozzles at a pre-determined velocity, and to desired depths. The quantity of fluid may contain one or more therapeutic agents, such as medications, drugs, bio-reactive agents, etc. The delivery actuator may also be configured to repeatedly deliver a quantity of the fluid contained in the reservoir through the at least one delivery nozzle at pre-determined intervals.

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element.

Abstract: A radio frequency (RF) pediatric coil for magnetic resonance/imaging analysis is disclosed. The coil includes a first end ring having a generally annular opening, and at least one of a second end ring and an end cap. An anterior extension is formed on the first end ring and on the at least one of the second end ring and the end cap. A plurality of elongated segments are coupled to and positioned circumferentially around the first end ring and the at least one of the second end ring and the end cap to form a coil volume. A first elongated segment and a second elongated segment are spaced about the anterior extension to facilitate access into the coil volume. The coil can be implemented as a standalone coil, or it can be operatively coupled to an incubator to increase the resolution of magnetic resonance scans of a neonate inside the incubator.

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially.

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element.

Abstract: A radiographic imaging sub-system for treating neonates is disclosed. The subsystem includes a radiographic compatible incubator for providing a controlled environment for a neonate, a radiographic compatible RF coil selectively coupled to the incubator for providing radiographic imaging of the neonate, and a radiographic compatible trolley for transporting the incubator and the RF coil. Additionally, the sub-system can include a radiographic MR compatible vital signs monitor, a radiographic compatible infusion pump, a radiographic compatible injector, a radiographic compatible ventilator, a radiographic compatible blender, radiographic compatible intravenous pole, tanks, pressure reducers/gauges and flow pipes.

Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

Abstract: An RF coil array is provided with increased S/N over the entire imaging FOV. The array design includes a first RF coil spanning the entire FOV, second and third RF coils which together span the entire FOV such that the entire system provides improved S/N over the imaging FOV. An aspect of the invention is the unusual combination of coils in one integrated structure, that are well isolated from one another and maintain preferred current distributions and mode orientations.

Abstract: An active, transdermal delivery system includes a support structure and a fluid reservoir within the support structure configured to contain a fluid to be delivered transdermally. There is also at least one exit orifice defined in the support structure that is in communication with the fluid reservoir. The orifice has a diameter of between about 1 &mgr;m and 500 &mgr;m. Furthermore, a repeatable activation means is disposed within the support structure and is in cooperation with the exit orifice for ejection of fluid in response to an activation signal.

Abstract: A method, an apparatus, and a computer program product are disclosed for detecting memory-related errors in a computer program during compiling of the computer program. In the method, static analysis is performed upon a computer program. One or more conditions in the computer program are computed based on the static analysis. Each condition is a test for checking a memory access in the computer program and can be either a pre- or post-condition. The validity of each condition in the computer program is then evaluated. If the evaluation is determinate during compiling, the presence or absence of memory-related errors in the computer program is reported. A condition is determinate if the condition is valid or invalid during compiling. Otherwise, computer code based on the condition is generated for incorporation in the computer program for run-time detection of memory-related errors.

Abstract: A method for high throughput mechanical property testing of materials libraries using capacitance. The method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.

Abstract: A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.