Patents by Inventor Ravi V. Bellamkonda
Ravi V. Bellamkonda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11273250Abstract: Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.Type: GrantFiled: August 4, 2011Date of Patent: March 15, 2022Assignees: GEORGIA TECH RESEARCH CORPORATION, CHILDREN'S HEALTHCARE OF ATLANTA, INC.Inventors: Ravi V. Bellamkonda, Anjana Jain, Nassir Mokarram-Dorri, Barun Brahma
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Patent number: 10981007Abstract: Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.Type: GrantFiled: May 12, 2017Date of Patent: April 20, 2021Assignee: Georgia Tech Research CorporationInventors: Yogi Anil Patel, Ravi V. Bellamkonda, Robert Butera, Tarun Saxena
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Publication number: 20190184166Abstract: Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.Type: ApplicationFiled: May 12, 2017Publication date: June 20, 2019Inventors: Yogi Anil PATEL, Ravi V. BELLAMKONDA, Robert BUTERA, Tarun SAXENA
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Publication number: 20180116958Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.Type: ApplicationFiled: December 29, 2017Publication date: May 3, 2018Inventors: Jennifer M. Munson, Ravi V. Bellamkonda, Jack L. Arbiser
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Patent number: 9872834Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.Type: GrantFiled: December 28, 2015Date of Patent: January 23, 2018Assignees: Emory University, Georgia Tech Research Corporation, Children's Healthcare of Atlanta, Inc.Inventors: Jennifer M. Munson, Ravi V. Bellamkonda, Jack L. Arbiser
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Publication number: 20160113873Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.Type: ApplicationFiled: December 28, 2015Publication date: April 28, 2016Inventors: Jennifer M. Munson, Ravi V. Bellamkonda, Jack L. Arbiser
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Patent number: 9220682Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.Type: GrantFiled: April 21, 2010Date of Patent: December 29, 2015Assignees: Emory University, Georgia Tech Research Corporation, Children's Healthcare of Atlanta, Inc.Inventors: Jennifer M. Munson, Ravi V. Bellamkonda, Jack L. Arbiser
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Patent number: 8911708Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: GrantFiled: December 17, 2012Date of Patent: December 16, 2014Assignee: Marval Pharma, Inc.Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Patent number: 8652215Abstract: A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75% of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.Type: GrantFiled: March 7, 2006Date of Patent: February 18, 2014Assignee: Georgia Tech Research CorporationInventors: Ravi V. Bellamkonda, Young-Tae Kim, Satish Kumar, Dasharatham Goud Janagama
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Publication number: 20130189187Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: ApplicationFiled: December 17, 2012Publication date: July 25, 2013Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Publication number: 20130172846Abstract: Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.Type: ApplicationFiled: August 4, 2011Publication date: July 4, 2013Applicant: Georgia Tech Research CorporationInventors: Ravi V. Bellamkonda, Anjana Jain
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Patent number: 8357351Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: GrantFiled: January 22, 2009Date of Patent: January 22, 2013Inventors: Ananth Annapragada, Efstathios Karathanasis, Ravi V. Bellamkonda, Russell M. Lebovitz
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Publication number: 20120052115Abstract: Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.Type: ApplicationFiled: April 21, 2010Publication date: March 1, 2012Applicants: Emory University, Georgia Tech Research CorporationInventors: Jennifer M. Munson, Ravi V. Bellamkonda, Jack L. Arbiser
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Patent number: 7785568Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: GrantFiled: November 10, 2006Date of Patent: August 31, 2010Assignee: Marval Biosciences, Inc.Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi
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Patent number: 7749496Abstract: A method of promoting neuronal regeneration includes administering an agent to at least one neural cell in contact with at least one neural cell growth inhibiting component in an amount effective to promote neuronal regeneration. The agent is selected from the group consisting of a Class I Rho family GTPase, a C1 activator, a Class II Rho family GTPase, and a C2 inhibitor.Type: GrantFiled: January 7, 2004Date of Patent: July 6, 2010Assignee: Case Western Reserve UniversityInventors: Susann Brady-Kalnay, Ravi V. Bellamkonda
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Patent number: 7713517Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: GrantFiled: April 21, 2004Date of Patent: May 11, 2010Assignee: Marval Biosciences, Inc.Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi
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Publication number: 20090263326Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: ApplicationFiled: January 22, 2009Publication date: October 22, 2009Applicant: Marval BioSciences, Inc.Inventors: Efstathios Karathanasis, Russell M. Lebovitz, Ananth Annapragada, Ravi V. Bellamkonda
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Publication number: 20080208358Abstract: A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75% of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.Type: ApplicationFiled: March 7, 2006Publication date: August 28, 2008Applicant: GEORGIA TECH RESEARCH CORPORATIONInventors: Ravi V. Bellamkonda, Young-Tae Kim, Satish Kumar
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Publication number: 20080131369Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: ApplicationFiled: January 12, 2005Publication date: June 5, 2008Applicant: MARVEL THERAPEUTICSInventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi, Chen-Yu Kao, Ketan Ghaghada
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Patent number: RE45195Abstract: Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.Type: GrantFiled: February 15, 2013Date of Patent: October 14, 2014Assignees: Marval Pharma, Inc., Case Western Reserve University, Cleveland State UniversityInventors: Ananth Annapragada, Ravi V. Bellamkonda, Eric Hoffman, Chandra Vijayalakshmi, Chen-Yu Kao