Abstract: Provided herein are methods for producing quiescent cardiac fibroblast cells from pluripotent stem cells. Further provided herein are microtissue compositions comprising the cardiac fibroblast cells with endothelial cells and cardiomyocytes.

Abstract: An apparatus comprising: at least one processor; and at least one memory including computer program code, the at least one memory and computer program code configured to, with the at least one processor, cause the apparatus to: receive a sensor output from a mechanomyography sensor configured to monitor muscle activity of a muscle in a human or animal body; and control, in response to the received sensor output, an electrical stimulus applied by a muscle stimulator to the muscle to modify said muscle activity, wherein the electrical stimulus is applied with an amplitude below the motor threshold of the muscle simultaneously during monitoring of the muscle activity by the mechanomyography sensor.

Abstract: An apparatus configured for application to a surface of a body, the apparatus comprising: an array of mechanomyography sensors spatially distributed across a substrate, each mechanomyography sensor configured to detect mechanomyography signals from the body to which the apparatus is applied; and a pressure bias system configured to provide a variation in contact pressure of the mechanomyography sensors to the body surface to receive mechanomyography signals at different levels of applied contact pressure.

Abstract: A system for behaviour mapping and categorization of objects and users in an 3D environment for creating and learning user behaviour map is provided. The system includes a robot 102, a network 104 and a central AI system 106. The robot 102 is embedded with an array of acoustic sensors 108 and visual sensors 110 for behaviour mapping and categorization the objects and users in the 3D environment and generates an auditory behaviour map and a visual behaviour map based on sensory inputs from the acoustic sensors 108 and visual sensors 110. The robot 102 transmits the acoustic source sensory input and the visual source sensory input to the central AI system 106 over the network 104 for generating a global behaviour map. The central AI system 106 tunes the global behaviour map to a specific user by tuning the detection and classification model to data obtained from a specific 3D environment that corresponds to the specific user.

Abstract: Provided herein is technology relating to differentiated stem cells and particularly, but not exclusively, to stem-cell derived cardiomyocytes having improved inward rectifier currents (e.g., IK1 currents), methods for producing stem-cell derived cardiomyocytes having inward rectifier currents, and systems and uses related to stem-cell derived cardiomyocytes having enhanced inward rectifier currents.

Abstract: A wearable sensor apparatus comprises a motion sensor configured to sense two or three dimensional movement and orientation of the sensor and a vibration sensor configured to sense acoustic vibrations. The apparatus includes means for attaching the motion sensor and the vibration sensor to a body. The sensor apparatus enables long term monitoring of mechanomyographic muscle activity in combination with body motion for a number of applications.

Abstract: A wearable sensor apparatus comprises a motion sensor configured to sense two or three dimensional movement and orientation of the sensor and a vibration sensor configured to sense acoustic vibrations. The apparatus includes means for attaching the motion sensor and the vibration sensor to a body. The sensor apparatus enables long term monitoring of mechanomyographic muscle activity in combination with body motion for a number of applications.

Abstract: A wearable sensor apparatus comprises a motion sensor configured to sense two or three dimensional movement and orientation of the sensor and a vibration sensor configured to sense acoustic vibrations. The apparatus includes means for attaching the motion sensor and the vibration sensor to a body. The sensor apparatus enables long term monitoring of mechanomyographic muscle activity in combination with body motion for a number of applications.

Abstract: A single step routing and wavelength assignment method and system for automated provisioning of services on DWDM networks is presented. This novel single step solution automates design and assignment of services in DWDM networks. For an automated provisioning platform that can handle the routing and wavelength assignment in a single step, the solution avoids reconfiguration of existing services. It also takes into consideration practical aspects of DWDM transponder availability at termination sites and regeneration sites along the selected route. The methodology includes iterative computation of common channel sets to avoid multiple shortest path computations for each of the wavelengths.

Abstract: A single step routing and wavelength assignment method and system for automated provisioning of services on DWDM networks is presented. This novel single step solution automates design and assignment of services in DWDM networks. For an automated provisioning platform that can handle the routing and wavelength assignment in a single step, the solution avoids reconfiguration of existing services. It also takes into consideration practical aspects of DWDM transponder availability at termination sites and regeneration sites along the selected route. The methodology includes iterative computation of common channel sets to avoid multiple shortest path computations for each of the wavelengths.

Abstract: A predictive system and method for aircraft load balancing and handoff management leverages the aircraft flight plan as well as channel occupancy and loading information. Several novel techniques are applied to the load balancing and handoff management problem: Use of aircraft position and flight plan information to geographically and temporally predict the appropriate ground stations that the aircraft should connect to for handoff, and monitoring the load of ground stations and using the ground-requested, aircraft initiated handoff procedure to influence the aircraft to connect to lightly loaded ground stations.

Abstract: A router receives destination address information for a packet and determines, among entries in a first forwarding table, a closest match for the received destination address information. The router receives a pointer to a second forwarding table in accordance with the closest match determined in the first forwarding table and determines, among entries in the second forwarding table, a closest match for the received destination address information.

Abstract: A router receives destination address information for a packet and determines, among entries in a first forwarding table, a closest match for the received destination address information. The router receives a pointer to a second forwarding table in accordance with the closest match determined in the first forwarding table and determines, among entries in the second forwarding table, a closest match for the received destination address information.

Abstract: A method and computer program product comprising an algorithm adapted to execute a method of identifying the spatial coordinates of a sustaining source of fibrillatory activity in a heart by computing a set of point-dependent dominant frequencies and a set of point-dependent regularity indices for a set of products of point-dependent unipolar discrete power spectra and point-dependent bipolar discrete power spectra, derived by spectral analyses of corresponding unipolar and bipolar cardiac depolarization signals simultaneously acquired from a set of points of the heart. A maximum dominant frequency is selected whose associated coordinates identify the point of the sustaining source of fibrillatory activity. The magnitude of the regularity index is interpreted to verify the identification of the spatial coordinates of the sustaining source of fibrillatory activity. When indicated, surgical intervention is directed to the spatial coordinates of the sustaining source of fibrillatory activity.

Abstract: A router receives destination address information for a packet and determines, among entries in a first forwarding table, a closest match for the received destination address information. The router receives a pointer to a second forwarding table in accordance with the closest match determined in the first forwarding table and determines, among entries in the second forwarding table, a closest match for the received destination address information.

Abstract: A method and computer program product comprising an algorithm adapted to execute a method of identifying the spatial coordinates of a sustaining source of fibrillatory activity in a heart by computing a set of point-dependent dominant frequencies and a set of point-dependent regularity indices for a set of products of point-dependent unipolar discrete power spectra and point-dependent bipolar discrete power spectra, derived by spectral analyses of corresponding unipolar and bipolar cardiac depolarization signals simultaneously acquired from a set of points of the heart. A maximum dominant frequency is selected whose associated coordinates identify the point of the sustaining source of fibrillatory activity. The magnitude of the regularity index is interpreted to verify the identification of the spatial coordinates of the sustaining source of fibrillatory activity. When indicated, surgical intervention is directed to the spatial coordinates of the sustaining source of fibrillatory activity.