Patents by Inventor Ravikumar Muthuswamy

Ravikumar Muthuswamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACTIVE CXCR4+ IMMUNE CELLS AND METHODS FOR THEIR PRODUCTION AND USE
    Publication number: 20210071143
    Abstract: Provided herein are active CXCR4+ CD8; T cells, active CXCR4+ type-1 CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells and populations of those cells, and methods for using active CXCR4+ T cells and NK cells and populations of those cells for the treatment of cancer, precartcerous conditions and chronic infections.
    Type: Application
    Filed: September 23, 2020
    Publication date: March 11, 2021
    Inventors: Pawel KALINSKI, Ravikumar MUTHUSWAMY
  • Active CXCR4+ immune cells and methods for their production and use
    Patent number: 10815457
    Abstract: Provided herein are active CXCR4+ CD8+ T cells, active CXCR4+ type-1 CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells and populations of those cells, and methods for using active CXCR4+ T cells and NK cells and populations of those cells for the treatment of cancer, precancerous conditions and chronic infections.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 27, 2020
    Assignee: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION
    Inventors: Pawel Kalinski, Ravikumar Muthuswamy
  • ACTIVE CXCR4+ IMMUNE CELLS AND METHODS FOR THEIR PRODUCTION AND USE
    Publication number: 20170260507
    Abstract: Provided herein are active CXCR4+ CD8+ T cells, active CXCR4+ type-1 CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells and populations of those cells, and methods for using active CXCR4+ T cells and NK cells and populations of those cells for the treatment of cancer, precancerous conditions and chronic infections.
    Type: Application
    Filed: November 24, 2015
    Publication date: September 14, 2017
    Inventors: Pawel KALINSKI, Ravikumar MUTHUSWAMY
  • Tumor Selective Chemokine Modulation
    Publication number: 20140255341
    Abstract: Therapies effective for the treatment and prevention of cancer and other diseases are disclosed. These methods include the administration of therapeutically effective amounts of agents that increase the local production of effector cell-attracting chemokines within tumor lesions, with concomitant suppression of local production of undesirable chemokines that attract regulatory T(reg) cells. These methods include administering to the subject therapeutically effective amounts of a Toll-like receptor (TLR) agonist or other activator of NF-KB pathway in combination with a blocker of prostaglandin synthesis or a blocker of prostaglandin signaling, in combination with a type-1 interferon, or in combination with both a blocker of prostaglandin synthesis or signaling and with a type-1 interferon.
    Type: Application
    Filed: July 23, 2012
    Publication date: September 11, 2014
    Inventors: Pawel Kalinski, Ravikumar Muthuswamy
  • CCL18 and CCL3 methods and compositions for detecting and treating cancer
    Patent number: 8445442
    Abstract: The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: May 21, 2013
    Assignee: University of Vermont and State Agricultural College
    Inventors: Marcus Bosenberg, Christopher Matthew Bradbury, Ravikumar Muthuswamy
  • CCL18 AND CCL3 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CANCER
    Publication number: 20100305043
    Abstract: The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma.
    Type: Application
    Filed: April 25, 2008
    Publication date: December 2, 2010
    Applicant: UNIVERISTY OF VERMONT AND STATE AGRICULTURAL COLLEGE
    Inventors: Marcus Bosenberg, Christopher Matthew Bradbury, Ravikumar Muthuswamy