Patents by Inventor Ravikumar Puppala
Ravikumar Puppala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230075170Abstract: The present invention relates to the solid forms of Nilotinib D-Malate and Nilotinib D-Tartrate, processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: February 15, 2021Publication date: March 9, 2023Inventors: Srinivas Laxminarayan PATHI, Ramanaiah CHENNURU, Ravikumar PUPPALA, Raju BARLA, Krishna RAGHAVENDRA
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Publication number: 20190270735Abstract: The present invention provides novel polymorphic forms of dasatinib compound of the formula 1 as well as the process for the preparation thereof.Type: ApplicationFiled: October 30, 2017Publication date: September 5, 2019Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Yellanki JAGANNADHAM, Ramanaiah CHENNURU
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Patent number: 10287248Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 15, 2016Date of Patent: May 14, 2019Assignee: CIPLA LIMITEDInventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Suryanarayana Durga Yarra
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Publication number: 20180237390Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 15, 2016Publication date: August 23, 2018Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Suryanarayana Durga YARRA
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Patent number: 10023611Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.Type: GrantFiled: April 16, 2014Date of Patent: July 17, 2018Assignee: Cipla LimitedInventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
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Patent number: 9505787Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert -butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L -phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.Type: GrantFiled: September 11, 2013Date of Patent: November 29, 2016Assignee: Cipla LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala
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Publication number: 20160075736Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.Type: ApplicationFiled: April 16, 2014Publication date: March 17, 2016Inventors: Ravikumar PUPPALA, Srinivas Laxminarayan PATHI, Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN
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Publication number: 20150246935Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert-butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L-phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.Type: ApplicationFiled: September 11, 2013Publication date: September 3, 2015Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala
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Patent number: 9062049Abstract: The present invention provides a process for the preparation of paliperidone or a pharmaceutically acceptable salt thereof, wherein the process comprises condensing a compound of formula (II) with a compound of formula (III) or a salt thereof, in a suitable solvent and a base, in the presence of a catalyst and an inhibiting agent, wherein the inhibiting agent is added to the reaction system before the compound of formula (II) and compound of formula (III) have reacted or as the reaction of the compound of formula (II) and compound of formula (III) is initiated, and optionally converting the paliperidone to a salt thereof, wherein X is a suitable leaving group. The present invention also provides substantially pure paliperidone or a salt thereof, paliperidone or a salt thereof as prepared by the process and uses of the paliperidone or salt thereof.Type: GrantFiled: May 30, 2012Date of Patent: June 23, 2015Assignee: Cipla LimitedInventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Rajendra Narayanrao Kankan
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Publication number: 20140200228Abstract: The present invention provides a process for the preparation of paliperidone or a pharmaceutically acceptable salt thereof, wherein the process comprises condensing a compound of formula (II) with a compound of formula (III) or a salt thereof, in a suitable solvent and a base, in the presence of a catalyst and an inhibiting agent, wherein the inhibiting agent is added to the reaction system before the compound of formula (II) and compound of formula (III) have reacted or as the reaction of the compound of formula (II) and compound of formula (III) is initiated, and optionally converting the paliperidone to a salt thereof, wherein X is a suitable leaving group. The present invention also provides substantially pure paliperidone or a salt thereof, paliperidone or a salt thereof as prepared by the process and uses of the paliperidone or salt thereof.Type: ApplicationFiled: May 30, 2012Publication date: July 17, 2014Applicant: CIPLA LIMITEDInventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Rajendra Narayanrao Kankan
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Patent number: 8691999Abstract: An improved process for the preparation of telmisartan, or a pharmaceutically acceptable salt thereof, comprises subjecting 1H-Benzimidazole-2-n-propyl-4-methyl-6-(1?-methyl benzimidazole-2?yl)] of formula (II), and methyl-4-(bromomethyl)biphenyl-2-carboxylate of formula (III) to condensation and hydrolysis in a single step:Type: GrantFiled: May 10, 2005Date of Patent: April 8, 2014Assignee: Cipla LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
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Patent number: 8288561Abstract: An N-[(2?-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.Type: GrantFiled: May 7, 2008Date of Patent: October 16, 2012Assignee: CIPLA LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
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Patent number: 8198451Abstract: A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph.Type: GrantFiled: November 13, 2007Date of Patent: June 12, 2012Assignee: CIPLA LimitedInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Manish Gangrade, Shashirekha Kanathala
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Patent number: 8076492Abstract: A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula V, b) deesterifying the compound of formula (V) with a base; and c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV), wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula. The trityl olmesartan medoxomil may be deprotected to produce olmesartan medoxomil.Type: GrantFiled: October 9, 2007Date of Patent: December 13, 2011Assignee: Cipla LimitedInventors: Srinivas Laxminarayan Pathi, Ravikumar Puppala, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
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Publication number: 20110105763Abstract: An N-[(2?-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.Type: ApplicationFiled: May 7, 2008Publication date: May 5, 2011Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
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Publication number: 20100152229Abstract: A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph.Type: ApplicationFiled: November 13, 2007Publication date: June 17, 2010Applicant: CIPLA LIMITEDInventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Manish Gangrade, Shashirekha Kanathala
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Publication number: 20070265288Abstract: The invention relates to a stable, non hygroscopic alpha crystalline form of methane sulfonic acid addition salt of 4-(4-methyl piperazin-1yl methyl)-N-[4-methyl-3-(4-pyridin-3-yl) pyrimidin-2-yl amino)phenyl]-benzamide (imatinib mesylate). A process for the preparation of the crystalline form is also described.Type: ApplicationFiled: September 2, 2005Publication date: November 15, 2007Inventors: Srinivas Pathi, Ravikumar Puppala, Rajendra Kankan, Dharmaraj Rao