Patents by Inventor Ravikumar Puppala

Ravikumar Puppala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230075170
    Abstract: The present invention relates to the solid forms of Nilotinib D-Malate and Nilotinib D-Tartrate, processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 15, 2021
    Publication date: March 9, 2023
    Inventors: Srinivas Laxminarayan PATHI, Ramanaiah CHENNURU, Ravikumar PUPPALA, Raju BARLA, Krishna RAGHAVENDRA
  • Publication number: 20190270735
    Abstract: The present invention provides novel polymorphic forms of dasatinib compound of the formula 1 as well as the process for the preparation thereof.
    Type: Application
    Filed: October 30, 2017
    Publication date: September 5, 2019
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Yellanki JAGANNADHAM, Ramanaiah CHENNURU
  • Patent number: 10287248
    Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: May 14, 2019
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Suryanarayana Durga Yarra
  • Publication number: 20180237390
    Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 15, 2016
    Publication date: August 23, 2018
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Suryanarayana Durga YARRA
  • Patent number: 10023611
    Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 17, 2018
    Assignee: Cipla Limited
    Inventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 9505787
    Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert -butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L -phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: November 29, 2016
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Publication number: 20160075736
    Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 17, 2016
    Inventors: Ravikumar PUPPALA, Srinivas Laxminarayan PATHI, Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN
  • Publication number: 20150246935
    Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert-butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L-phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.
    Type: Application
    Filed: September 11, 2013
    Publication date: September 3, 2015
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Patent number: 9062049
    Abstract: The present invention provides a process for the preparation of paliperidone or a pharmaceutically acceptable salt thereof, wherein the process comprises condensing a compound of formula (II) with a compound of formula (III) or a salt thereof, in a suitable solvent and a base, in the presence of a catalyst and an inhibiting agent, wherein the inhibiting agent is added to the reaction system before the compound of formula (II) and compound of formula (III) have reacted or as the reaction of the compound of formula (II) and compound of formula (III) is initiated, and optionally converting the paliperidone to a salt thereof, wherein X is a suitable leaving group. The present invention also provides substantially pure paliperidone or a salt thereof, paliperidone or a salt thereof as prepared by the process and uses of the paliperidone or salt thereof.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: June 23, 2015
    Assignee: Cipla Limited
    Inventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Rajendra Narayanrao Kankan
  • Publication number: 20140200228
    Abstract: The present invention provides a process for the preparation of paliperidone or a pharmaceutically acceptable salt thereof, wherein the process comprises condensing a compound of formula (II) with a compound of formula (III) or a salt thereof, in a suitable solvent and a base, in the presence of a catalyst and an inhibiting agent, wherein the inhibiting agent is added to the reaction system before the compound of formula (II) and compound of formula (III) have reacted or as the reaction of the compound of formula (II) and compound of formula (III) is initiated, and optionally converting the paliperidone to a salt thereof, wherein X is a suitable leaving group. The present invention also provides substantially pure paliperidone or a salt thereof, paliperidone or a salt thereof as prepared by the process and uses of the paliperidone or salt thereof.
    Type: Application
    Filed: May 30, 2012
    Publication date: July 17, 2014
    Applicant: CIPLA LIMITED
    Inventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Rajendra Narayanrao Kankan
  • Patent number: 8691999
    Abstract: An improved process for the preparation of telmisartan, or a pharmaceutically acceptable salt thereof, comprises subjecting 1H-Benzimidazole-2-n-propyl-4-methyl-6-(1?-methyl benzimidazole-2?yl)] of formula (II), and methyl-4-(bromomethyl)biphenyl-2-carboxylate of formula (III) to condensation and hydrolysis in a single step:
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: April 8, 2014
    Assignee: Cipla Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Patent number: 8288561
    Abstract: An N-[(2?-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: October 16, 2012
    Assignee: CIPLA Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Patent number: 8198451
    Abstract: A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: June 12, 2012
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Manish Gangrade, Shashirekha Kanathala
  • Patent number: 8076492
    Abstract: A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula V, b) deesterifying the compound of formula (V) with a base; and c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV), wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula. The trityl olmesartan medoxomil may be deprotected to produce olmesartan medoxomil.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: December 13, 2011
    Assignee: Cipla Limited
    Inventors: Srinivas Laxminarayan Pathi, Ravikumar Puppala, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Publication number: 20110105763
    Abstract: An N-[(2?-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.
    Type: Application
    Filed: May 7, 2008
    Publication date: May 5, 2011
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Publication number: 20100152229
    Abstract: A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph.
    Type: Application
    Filed: November 13, 2007
    Publication date: June 17, 2010
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Manish Gangrade, Shashirekha Kanathala
  • Publication number: 20070265288
    Abstract: The invention relates to a stable, non hygroscopic alpha crystalline form of methane sulfonic acid addition salt of 4-(4-methyl piperazin-1yl methyl)-N-[4-methyl-3-(4-pyridin-3-yl) pyrimidin-2-yl amino)phenyl]-benzamide (imatinib mesylate). A process for the preparation of the crystalline form is also described.
    Type: Application
    Filed: September 2, 2005
    Publication date: November 15, 2007
    Inventors: Srinivas Pathi, Ravikumar Puppala, Rajendra Kankan, Dharmaraj Rao