Patents by Inventor Ravinder S. Dhallan
Ravinder S. Dhallan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110111971Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: ApplicationFiled: May 14, 2010Publication date: May 12, 2011Applicant: RAVGEN, INC.Inventor: Ravinder S. Dhallan
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Publication number: 20110059440Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5? overhang containing the locus of interest. The 5? overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: ApplicationFiled: October 2, 2009Publication date: March 10, 2011Applicant: RAVGEN, INC.Inventor: Ravinder S. Dhallan
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Patent number: 7727720Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: GrantFiled: August 26, 2005Date of Patent: June 1, 2010Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 7718370Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: GrantFiled: December 28, 2006Date of Patent: May 18, 2010Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 7598060Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5? overhang containing the locus of interest. The 5? overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: GrantFiled: April 15, 2005Date of Patent: October 6, 2009Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 7442506Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: GrantFiled: August 26, 2005Date of Patent: October 28, 2008Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 7332277Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: GrantFiled: September 11, 2003Date of Patent: February 19, 2008Assignee: RavGen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 7208274Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5? overhang containing the locus of interest. The 5? overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: GrantFiled: February 28, 2003Date of Patent: April 24, 2007Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Patent number: 6977162Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5? overhang containing the locus of interest. The 5? overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: GrantFiled: March 11, 2002Date of Patent: December 20, 2005Assignee: Ravgen, Inc.Inventor: Ravinder S. Dhallan
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Publication number: 20040137470Abstract: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.Type: ApplicationFiled: September 11, 2003Publication date: July 15, 2004Inventor: Ravinder S. Dhallan
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Publication number: 20040106102Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5′ overhang containing the locus of interest. The 5′ overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: ApplicationFiled: February 28, 2003Publication date: June 3, 2004Inventor: Ravinder S. Dhallan
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Publication number: 20030186239Abstract: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5′ overhang containing the locus of interest. The 5′ overhang is used as a template to incorporate nucleotides, which can be detected. The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.Type: ApplicationFiled: March 11, 2002Publication date: October 2, 2003Applicant: RavGen, Inc.Inventor: Ravinder S. Dhallan