Abstract: A system and method for monitoring a subject receiving supplemental oxygen and controlling supplemental oxygen delivery thereto, which includes utilizing one or more sensors to monitor physiologic parameters of the subject, analyzing the monitored physiologic parameters, and subject specific data and/or population data, to determine whether modification of treatment parameters, and/or attention of a caregiver, is required, and automatically modifying one or more of the treatment parameters or alerting the caregiver and/or subject, such that the treatment parameters of the subject may be modified to optimize the supplemental oxygen treatment. The method and system provided herein facilitate personalization of oxygen delivery to a subject in a need thereof.

Abstract: The present invention relates to system, device, and method utilizing cryosurgery to treat a tumor of the breast. More particularly, the present invention relates to treating a breast tumor by inserting into a breast, at a selected site known to be a locus of a tumor, an introducer having at least one access port, operating a biopsy needle through an access port to perform a biopsy of tissues at the selected site, and operating a cryoprobe through an access port to cool body tissues to cryoablation temperatures, thereby ablating or downsizing the tumor. The present invention further relates to use of cryoablation to downsize a large malignant tumor as pre-operative preparation for conventional excision surgery.