Patents by Inventor Ravshan BURIKHANOV

Ravshan BURIKHANOV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drugs for GRP78 cell surface translocation and Par-4 secretion
    Patent number: 11730750
    Abstract: A method of treating cancer in an individual includes a step of administering to the individual a pharmaceutically effective amount of (a) a first active agent adapted for producing secretion of prostate apoptosis response-4 (Par-4) from normal cells and (b) a second active agent adapted for elevating GRP78 receptors for Par-4 on a surface of a cancer cell in the individual.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: August 22, 2023
    Assignee: University of Kentucky Research Foundation
    Inventors: Vivek M. Rangnekar, Ravshan Burikhanov, David S. Watt
  • Novel Superebastine Against Therapy Resistant Prostate Cancer
    Publication number: 20220387412
    Abstract: A composition and method for treating tumor cells are provided. The composition includes at least one ebastine derivative having a structure according to Formula I. The method include administering, to a patient in need thereof, an effective amount of the composition including at least one ebastine derivative having the structure according to Formula I.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 8, 2022
    Inventors: Vivek M. Rangnekar, David S. Watt, Ravshan Burikhanov, Vitaliy Sviripa
  • DRUGS FOR GRP78 CELL SURFACE TRANSLOCATION AND PAR-4 SECRETION
    Publication number: 20210252032
    Abstract: A method of treating cancer in an individual includes a step of administering to the individual a pharmaceutically effective amount of (a) a first active agent adapted for producing secretion of prostate apoptosis response-4 (Par-4) from normal cells and (b) a second active agent adapted for elevating GRP78 receptors for Par-4 on a surface of a cancer cell in the individual.
    Type: Application
    Filed: February 17, 2021
    Publication date: August 19, 2021
    Inventors: Vivek M. Rangnekar, Ravshan Burikhanov, David S. Watt
  • NOVEL COMBINATION OF CRIZOTINIB WITH CHLOROQUINE FOR INHIBITION OF DIVERSE LUNG TUMORS
    Publication number: 20210046063
    Abstract: The presently-disclosed subject matter generally relates to methods for sensitizing chemotherapy resistant tumors using a synergistic drug combination. The presently-disclosed subject matter further relates to methods for sensitizing a drug resistant cancer cell to chemotherapy, comprising: contacting the drug resistant cancer cell with an effective amount of an agent capable of increasing cell surface expression of GRP78 and an agent capable of increasing soluble prostate apoptosis response 4 (Par-4).
    Type: Application
    Filed: August 13, 2020
    Publication date: February 18, 2021
    Inventors: Vivek M. Rangnekar, Ravshan Burikhanov
  • Arylquinoline and analog compounds and use thereof to treat cancer
    Patent number: 9873670
    Abstract: The subject technology relates to arylquinoline compounds and their use for treating cancer or cancer metastasis. The compounds of the subject technology promote cells to secrete a pro-apoptotic tumor suppressor, i.e., prostate apoptosis response-4 (Par-4), which in turn promote apoptosis in cancer cells or metastatic cells.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: January 23, 2018
    Assignee: University of Kentucky Research Foundation
    Inventors: David S. Watt, Chunming Liu, Vivek Rangnekar, Vitaliy M. Sviripa, Ravshan Burikhanov, Wen Zhang
  • ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER
    Publication number: 20160332971
    Abstract: Arylquinoline derivatives and their use for treating cancer or cancer metastasis is disclosed. The compounds of the subject technology promote cells to secrete a pro-apoptotic tumor suppressor, i.e., prostate apoptosis response-4 (Par-4), which in turn promote apoptosis in cancer cells or metastatic cells.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 17, 2016
    Inventors: David S. WATT, Chunming LIU, Vivek M. RANGNEKAR, Vitaliy M. SVIRIPA, Ravshan BURIKHANOV, Wen ZHANG
  • ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER
    Publication number: 20160280652
    Abstract: The subject technology relates to arylquinoline compounds and their use for treating cancer or cancer metastasis. The compounds of the subject technology promote cells to secrete a pro-apoptotic tumor suppressor, i.e., prostate apoptosis response-4 (Par-4), which in turn promote apoptosis in cancer cells or metastatic cells.
    Type: Application
    Filed: November 21, 2014
    Publication date: September 29, 2016
    Inventors: David S. WATT, Chunming LIU, Vivek RANGNEKAR, Vitaliy M. SVIRIPA, Ravshan BURIKHANOV, Wen ZHANG