Patents by Inventor Rawle I. Hollingsworth

Rawle I. Hollingsworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7498430
    Abstract: A process for the preparation and separation of the pentoses, xylose and arabinose from mixtures of saccharides by forming acetals is described. D-xylose is a precursor to xylitol, a sweetener, and L-arabinose is a precursor to the drug intermediate (R)-3,4-dihydroxybutyric acid, carnitine and agrichemicals.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: March 3, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventor: Rawle I. Hollingsworth
  • Patent number: 7390825
    Abstract: Substituted oxazolidinone of the formula: wherein R2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: June 24, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Guijun Wang, Raghavakaimal Padmakumar, Jianmin Mao, Huiping Zhang, Zongmin Dai, Kanakamma Puthuparampil
  • Publication number: 20080146458
    Abstract: Substituted oxazolidinone of the formula: wherein R2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
    Type: Application
    Filed: October 17, 2002
    Publication date: June 19, 2008
    Applicants: Board of Trustees of Michigan State University, Synthon Chiragenics Corporation
    Inventors: Rawle I. Hollingsworth, Guijun Wang, Raghavakaimal Padmakumar, Jianmin Mao, Huiping Zhang, Zongmin Dai, Kanakamma Puthuparampil
  • Patent number: 7342010
    Abstract: A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula: where x is 0 to 3.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: March 11, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Li Gao
  • Patent number: 7115706
    Abstract: Polyether polymers providing a backbone substituted at intervals with electron stabilizing groups containing electron withdrawing groups are described. The polymers capture electrons and are electronegative. The polymers act to solvate alkali metals so that electrons are withdrawn from the alkali metal into the polymer. The polymer compositions are conductive under certain conditions and are magnetic. The compositions are useful in electronic applications.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: October 3, 2006
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Yuqing Chen
  • Patent number: 6831176
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: December 14, 2004
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Publication number: 20040192645
    Abstract: Chitin has been discovered to accumulate in the diseased tissue of mammals, including humans, afflicted with a disease characterized by formation of congo red-staining plaques. Such diseases include Alzheimer's disease, spongiform encepalopathies, type II diabetes, atrial amyloidosis, and the like. A method for detecting the chitin in the mammal is described which is useful for diagnosing disease caused by accumulation of the chitin or amyloid plaques comprising chitin in tissue. Further described is a method for treating a disease in the mammal caused by the accumulation of chitin or amyloid plaques comprising chitin by administering a composition which inhibits formation of the chitin or degrades the chitin.
    Type: Application
    Filed: March 8, 2004
    Publication date: September 30, 2004
    Applicant: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Birgit Zipser, Linjuan Huang
  • Patent number: 6740780
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: May 25, 2004
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6683185
    Abstract: A process for the preparation of 1,5-dideoxy -1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: January 27, 2004
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6653480
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: November 25, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6653482
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: November 25, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6649766
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: November 18, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Publication number: 20030204091
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Application
    Filed: May 15, 2003
    Publication date: October 30, 2003
    Applicant: Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Publication number: 20030204092
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Application
    Filed: May 15, 2003
    Publication date: October 30, 2003
    Applicant: Board of Trustees Operating Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6605724
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: August 12, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6590121
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: July 8, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6583297
    Abstract: Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: June 24, 2003
    Assignee: Board of Trustees operating Michigan State University
    Inventor: Rawle I. Hollingsworth
  • Publication number: 20030109710
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Application
    Filed: January 7, 2003
    Publication date: June 12, 2003
    Applicant: Board of Trustees operating Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6541601
    Abstract: Polyamide polymers with side chains from a polyamide backbone, preferably containing carbon to carbon unsaturation which provides unique conductive and color change properties, are described. In particular, unsaturation is in the form of side chains from the polyamide backbone, with aligned diacetylene groups in each side chain which are aligned and in the same plane.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: April 1, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Guijun Wang
  • Patent number: 6518437
    Abstract: Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: February 11, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventor: Rawle I. Hollingsworth