Patents by Inventor Ray A. James

Ray A. James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boron-containing diacylhydrazine compounds
    Patent number: 10570158
    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: February 25, 2020
    Assignee: INTREXON CORPORATION
    Inventors: Ray A. James, Sheela K. Chellappan, Robert E. Hormann
  • Boron-Containing Diacylhydrazine Compounds
    Publication number: 20180201628
    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 19, 2018
    Inventors: Ray A. James, Sheela K. Chellappan, Robert E. Hormann
  • Boron-containing diacylhydrazine compounds
    Patent number: 9944659
    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 17, 2018
    Assignee: INTREXON CORPORATION
    Inventors: Ray A. James, Sheela K. Chellappan, Robert E. Hormann
  • Farnesyl protein transferase inhibitors as antitumor agents
    Patent number: 7342016
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: March 11, 2008
    Assignees: Schering Corporation, Pharmacopeia, Inc.
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy J. Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, James J-S Wang, Jagdish A. Desai
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20040122018
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Applicant: Schering Corporation
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20030229099
    Abstract: Disclosed are novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: February 27, 2002
    Publication date: December 11, 2003
    Inventors: Hugh Y. Zhu, F. George Njoroge, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Bancha Vibulbhan, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai
  • Novel farnesyl protein transferase inhibitors as antitumor agents
    Publication number: 20020198216
    Abstract: The present invention discloses novel tricyclic compounds represented by the formula (1.
    Type: Application
    Filed: August 28, 2001
    Publication date: December 26, 2002
    Inventors: F. George Njoroge, Bancha Vibulbhan, Alan B. Cooper, Timothy Guzi, Dinanath F. Rane, Keith P. Minor, Ronald J. Doll, Viyyoor M. Girijavallabhan, Bama Santhanam, Patrick A. Pinto, Hugh Y. Zhu, Kartik M. Keertikar, Carmen S. Alvarez, John J. Baldwin, Ge Li, Chia-Yu Huang, Ray A. James, W. Robert Bishop, James J-S Wang, Jagdish A. Desai