Patents by Inventor Ray McCarthy
Ray McCarthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240016958Abstract: A method and system for detecting and treating a clot are disclosed. The method of detecting composition of a clot in a vessel of a patient may include introducing a solution containing tagged tissue plasminogen activator (tPA) into a circulatory system of the patient, waiting a predetermined time for the tagged tPA to interact with the clot, scanning an area of the patient corresponding to the clot, and outputting a composition of the clot based on an intensity of a signal at the clot in the scan corresponding to the tagged tPA.Type: ApplicationFiled: July 15, 2022Publication date: January 18, 2024Applicant: Neuravi LimitedInventors: Anushree DWIVEDI, Ray MCCARTHY, Sarah JOHNSON
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Publication number: 20230364319Abstract: An aspiration catheter for assisting in the retrieval of a clot from a vessel of a patient including at least one electrode pair and a first pressure sensor positioned within an inner lumen of the aspiration catheter and a second and third pressure sensor positioned on an exterior surface of the aspiration catheter. The electrode pair and pressure sensors are in electrical communication with a control console. The control console is configured to modulate an aspiration vacuum pressure waveform pattern applied through the aspiration catheter based on electrical and pressure inputs from the one or more sensors, and optionally based on a blood pressure waveform pattern of the patient.Type: ApplicationFiled: May 12, 2022Publication date: November 16, 2023Applicants: Neuravi Limited, Biosense Webster (Israel) Ltd.Inventors: David VALE, Avi SHALGI, Ray McCARTHY, Michael GILVARRY, Brendan CASEY
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Publication number: 20230248379Abstract: Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate. Perfusion is restored to the blood vessel by passing the clot retrieval device by, through, or about the thrombus and removing the revascularization device to achieve, on the first pass, approximately a 63.2% final revascularization rate under the modified treatment in cerebral infarction score of equal to or greater than a grade of 2b (mTICI ?2b) for the plurality of human patients with one or more cerebral occlusions within a predetermined time period of natural stroke symptom onset.Type: ApplicationFiled: February 10, 2023Publication date: August 10, 2023Applicant: Neuravi LimitedInventor: Ray McCARTHY
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Publication number: 20230012025Abstract: Example systems and methods of treatment are presented herein which generally involve expanding a bracing frame within a blood vessel between a clot and an aspiration catheter, aspirating the clot through a passageway of the bracing frame, and supporting the blood vessel by the bracing frame as negative pressure is created by the aspiration. The bracing frame can thereby reduce likelihood of blood vessel collapse compared to a similar procedure which does not include the bracing frame. The bracing frame can be removed from the blood vessel during treatment. In some examples, the bracing frame can further function to expand a mouth of the catheter. In some examples, the system can include a stentriever.Type: ApplicationFiled: July 12, 2021Publication date: January 12, 2023Applicant: Neuravi LimitedInventors: David VALE, Brendan CASEY, Karl KEATING, Ronald KELLY, Ray McCARTHY, Mahmood MIRZA, Sarah JOHNSON, Anushree DWIVEDI
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Publication number: 20220133343Abstract: A device and method for establishing retrograde blood flow during recanalization of a vessel having a targeted blockage. While in a collapsed state an occluding component is introduced distally intravascularly traversing the targeted blockage to its distal side. Then, the occluding component transitions to an expanded state having an enlarged diameter forming a seal with an internal wall of the vessel prohibiting anterograde blood flow beyond the expanded occluding component. Retrograde blood flow is thereby established in a region of the vessel bound at one end by the occluding component and at an opposite end by the targeted blockage by dispensing a flushing fluid into the region of the vessel.Type: ApplicationFiled: January 13, 2022Publication date: May 5, 2022Inventor: Ray McCarthy
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Patent number: 11253287Abstract: A device and method for establishing retrograde blood flow during recanalization of a vessel having a targeted blockage. While in a collapsed state an occluding component is introduced distally intravascularly traversing the targeted blockage to its distal side. Then, the occluding component transitions to an expanded state having an enlarged diameter forming a seal with an internal wall of the vessel prohibiting anterograde blood flow beyond the expanded occluding component. Retrograde blood flow is thereby established in a region of the vessel bound at one end by the occluding component and at an opposite end by the targeted blockage by dispensing a flushing fluid into the region of the vessel.Type: GrantFiled: October 4, 2018Date of Patent: February 22, 2022Assignee: NEURAVI LIMITEDInventor: Ray McCarthy
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Publication number: 20210315599Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.Type: ApplicationFiled: August 23, 2019Publication date: October 14, 2021Applicant: NEURAVI LIMITEDInventors: David VALE, Brendan CASEY, Mahmood MIRZA, Ray McCARTHY, Patrick CONNOLLY
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Publication number: 20200107851Abstract: A device and method for establishing retrograde blood flow during recanalization of a vessel having a targeted blockage. While in a collapsed state an occluding component is introduced distally intravascularly traversing the targeted blockage to its distal side. Then, the occluding component transitions to an expanded state having an enlarged diameter forming a seal with an internal wall of the vessel prohibiting anterograde blood flow beyond the expanded occluding component. Retrograde blood flow is thereby established in a region of the vessel bound at one end by the occluding component and at an opposite end by the targeted blockage by dispensing a flushing fluid into the region of the vessel.Type: ApplicationFiled: October 4, 2018Publication date: April 9, 2020Inventor: Ray McCarthy
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Patent number: 10443107Abstract: A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).Type: GrantFiled: July 25, 2018Date of Patent: October 15, 2019Assignee: Boston Scientific Scimed, Inc.Inventors: Crystal Marie Anderson-Cunanan, Daniel J. Foster, Ray McCarthy, Mary M. Byron, David Robert Wulfman, Bradley S. Swehla
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Publication number: 20180327871Abstract: A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).Type: ApplicationFiled: July 25, 2018Publication date: November 15, 2018Inventors: Crystal Marie Anderson-Cunanan, Daniel J. Foster, Ray McCarthy, Mary M. Byron, David Robert Wulfman, Bradley S. Swehla
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Patent number: 10080650Abstract: A method of treating pericardial tissue that includes contacting at least a portion of a pericardial sac with a chemical while the pericardial sac is tensioned by an application of fluid pressure to an inside face of the pericardial sac.Type: GrantFiled: February 3, 2016Date of Patent: September 25, 2018Assignee: Boston Scientific Scimed, Inc.Inventor: Ray McCarthy
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Patent number: 10080820Abstract: A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).Type: GrantFiled: August 29, 2016Date of Patent: September 25, 2018Assignee: Boston Scientific Scimed, Inc.Inventors: Crystal Marie Anderson-Cunanan, Daniel J. Foster, Ray McCarthy, Mary M. Byron, David Robert Wulfman, Bradley S. Swehla
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Publication number: 20170065744Abstract: A tissue modification apparatus includes at least a first plurality of grippers aligned in a plane adapted to secure a first edge of a patch of tissue. The plurality of grippers are each secured to a first force actuator. The first plurality of grippers are each adapted to pivot relative to the first force actuator about an axis perpendicular to the plane. In some cases, a plurality of grippers are attached to a force actuator by a passive force transfer mechanism. In some cases, individual force actuators are attached by pivoted connections to individual grippers. Methods of treating tissue can secure tensioned tissue to a frame to retain the tension during a treatment (e.g., cross-linking the tissue with a chemical cross-linker).Type: ApplicationFiled: August 29, 2016Publication date: March 9, 2017Inventors: Crystal Marie Anderson-Cunanan, Daniel J. Foster, Ray McCarthy, Mary M. Byron, David Robert Wulfman, Bradley S. Swehla
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Publication number: 20160220362Abstract: A method of treating pericardial tissue that includes contacting at least a portion of a pericardial sac with a chemical while the pericardial sac is tensioned by an application of fluid pressure to an inside face of the pericardial sac.Type: ApplicationFiled: February 3, 2016Publication date: August 4, 2016Inventor: Ray McCarthy
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Publication number: 20160022254Abstract: This document relates to tissue modification and, more particularly, to modification of biological tissue for implantation in a mammal. For example, this document relates to tissue tensioning devices and methods used during fixation of tissues for bioprosthetic heart valves.Type: ApplicationFiled: July 21, 2015Publication date: January 28, 2016Inventor: Ray McCarthy
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Patent number: 7846937Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, methods of using the same, processes for preparing the same, and intermediates thereof.Type: GrantFiled: May 4, 2006Date of Patent: December 7, 2010Assignee: Eli Lilly and CompanyInventors: David Michael Bender, James Ray McCarthy
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Patent number: 7745438Abstract: The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.Type: GrantFiled: September 20, 2005Date of Patent: June 29, 2010Assignee: Eli Lilly and CompanyInventors: Howard Barff Broughton, Robert Dean Dally, Timothy Barrett Durham, Maria Rosario Gonzalez-Garcia, Patric James Hahn, Kenneth James Henry, Jr., Todd Jonathan Kohn, James Ray McCarthy, Timothy Alan Shepherd, Jon Andre Erickson, Ana Belen Bueno Melendo
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Patent number: 7618978Abstract: The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.Type: GrantFiled: April 8, 2005Date of Patent: November 17, 2009Assignee: Eli Lilly and CompanyInventors: Ana Belen Bueno Melendo, Shu-Hui Chen, Maria Rosario Gonzalez-Garcia, James Ray McCarthy
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Publication number: 20090270428Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, methods of using the same, processes for preparing the same, and intermediates thereof.Type: ApplicationFiled: May 4, 2006Publication date: October 29, 2009Inventors: David Michael Bender, James Ray McCarthy
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Patent number: 7345070Abstract: Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: n is 2, 3, or 4 and W is CH2, CH(OH), C(O) or O; R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl-alkyl, heteroaryl-alkyl, cycloalkyl-alkyl, or t-butyl; R2 is H, alkyl, haloalkyl or phenyl; Y is an unsubstituted or substituted thiophen-2,5-diyl or phenylene; R3 is alkyl or haloalkyl; R4 is a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, quinolyl, pyridyl or benzo[1,3]dioxol-5-yl group; and R5 is H, alkyl, or aminoalkyl; are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.Type: GrantFiled: February 9, 2005Date of Patent: March 18, 2008Assignee: Eli Lilly and CompanyInventors: Dawn Alisa Brooks, Alexander Glenn Godfrey, Sarah Beth Jones, James Ray McCarthy, Christopher John Rito, Leonard Larry Winneroski, Yanping Xu