Patents by Inventor Ray R. Radtkey
Ray R. Radtkey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965883Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: GrantFiled: November 7, 2019Date of Patent: April 23, 2024Assignee: Nanomix, Inc.Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Publication number: 20200232981Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: ApplicationFiled: November 7, 2019Publication date: July 23, 2020Applicant: Nanomix, Inc.Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Patent number: 10520501Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: GrantFiled: September 9, 2016Date of Patent: December 31, 2019Assignee: Nanomix, Inc.Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Publication number: 20170153230Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: ApplicationFiled: September 9, 2016Publication date: June 1, 2017Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Patent number: 9458488Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: GrantFiled: March 15, 2013Date of Patent: October 4, 2016Assignee: Nanomix, Inc.Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Publication number: 20150060272Abstract: Devices to detect detecting endotoxin (lipopolysaccharide or LPS) and/or 1-3-?-D-glucan (beta glucan or BG) using substrates including electrogenic mediators for amperometric detection are provided herein. Substrates include an amine group as well as one or more substituted organic rings, such as a phenol. Devices include cartridges for detecting LPS or BG simultaneously using dual detection techniques.Type: ApplicationFiled: November 14, 2014Publication date: March 5, 2015Inventors: Richard Andrew Blidner, Albert Gutes-Regidor, Ray R. Radtkey
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Publication number: 20140273187Abstract: Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Bradley N. Johnson, Jui-Ming Yang, Kanchan A. Joshi, Ray R. Radtkey, Garrett Gruener, Sergei Skarupo
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Patent number: 8772467Abstract: An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.Type: GrantFiled: October 7, 2009Date of Patent: July 8, 2014Assignee: Gamida for Life B.V.Inventors: Ray R. Radtkey, Lance C. Held, Robert B. Wallace, Karen Menge, David Canter
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Publication number: 20100167960Abstract: An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.Type: ApplicationFiled: October 7, 2009Publication date: July 1, 2010Inventors: Ray R. Radtkey, Lance C. Held, Robert B. Wallace, Karen Menge, David Canter
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Patent number: 7601493Abstract: An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.Type: GrantFiled: July 24, 2003Date of Patent: October 13, 2009Assignee: Nanogen, Inc.Inventors: Ray R. Radtkey, Lance C. Held, Robert B. Wallace, Karen Menge, David Canter
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Patent number: 7582421Abstract: This application includes methods for detecting single nucleotide polymorphisms (SNPs) in a sample using an electronically addressable microchip having a plurality of test sites. A sample nucleic acid is electronically biased, concentrated at, and immobilized to a test site on the microchip. A mixture comprising a first labeled probe and a second labeled probe is electronically hybridized to the sample nucleic acid to form first or second hybridized complexes. The first labeled probe is perfectly complementary to the first sample nucleic acid and the second labeled probe is complementary to the sample nucleic acid and contains a nucleotide that forms a mismatch with the nucleotide at the site of the polymorphism. The first or second hybridized complexes are detected by determining a signal intensity of the label of the first or second probe.Type: GrantFiled: September 16, 2002Date of Patent: September 1, 2009Assignee: Nanogen, Inc.Inventors: Ronald G. Sosnowski, Michael I. Nerenberg, David M. Canter, Ray R. Radtkey, Ling Wang, James P. O'Connell
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Publication number: 20090087846Abstract: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.Type: ApplicationFiled: May 9, 2008Publication date: April 2, 2009Inventors: Ray R. Radtkey, Douglas Whitman, Graham Lidgard
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Publication number: 20040146880Abstract: An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.Type: ApplicationFiled: July 24, 2003Publication date: July 29, 2004Applicant: Nanogen, Inc.Inventors: Ray R. Radtkey, Lance C. Held, Robert B. Wallace, Karen Menge, David Canter
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Publication number: 20030073122Abstract: Methods are provided for the analysis and determination of the nature of single nucleic acid polymorphisms (SNPs) in a genetic target. In one method of this invention, the nature of the SNPs in the genetic target is determined by the steps of providing a plurality of hybridization complexes arrayed on a plurality of test sites on an electronically bioactive microchip, where the hybridization complex includes at least a nucleic acid target containing a SNP, a stabilizer probe having a sequence complementary to the target sequence and/or reporter probe, and a reporter probe having a selected sequence complementary to either the stabilizer or the same target sequence strand wherein a selected sequence of the reporter includes either a wild type nucleotide or a nucleotide corresponding to the SNP of the target.Type: ApplicationFiled: September 16, 2002Publication date: April 17, 2003Applicant: Nanogen, Inc.Inventors: Ronald G. Sosnowski, Michael I. Nerenberg, David M. Canter, Ray R. Radtkey, Ling Wang, James P. O'Connell
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Patent number: 6468742Abstract: Methods are provided for the analysis and determination of the nature of single nucleic acid polymorphisms (SNPs) in a genetic target. In one method of this invention, the nature of the SNPs in the genetic target is determined by the steps of providing a plurality of hybridization complexes arrayed on a plurality of test sites on an electronically bioactive microchip, where the hybridization complex includes at least a nucleic acid target containing a SNP, a stabilizer probe having a sequence complementary to the target sequence and/or reporter probe, and a reporter probe having a selected sequence complementary to either the stabilizer or the same target sequence strand wherein a selected sequence of the reporter includes either a wild type nucleotide or a nucleotide corresponding to the SNP of the target.Type: GrantFiled: April 12, 1999Date of Patent: October 22, 2002Assignee: Nanogen, Inc.Inventors: Michael I. Nerenberg, David M. Canter, Ray R. Radtkey, Ling Wang, James P. O'connell, Ronald G. Sosnowski
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Publication number: 20020119470Abstract: This invention provides a bead array counter system that combines strand displacement amplification with magnetoresistive micro sensor chips and magnetic beads. The system allows for detection of target nucleic acids in highly dilute samples. The system further provides a means to detect specific nucleic acid sequences comprising SNPs and STRs.Type: ApplicationFiled: October 5, 2001Publication date: August 29, 2002Inventors: Michael I. Nerenberg, Geoffrey C. Landis, Lorelei P. Westin, James P. O'Connell, Ling Wang, Ray R. Radtkey, Lana L. Feng
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Publication number: 20010014449Abstract: Methods are provided for the analysis and determination of the nature of single nucleic acid polymorphisms (SNPs) in a genetic target. In one method of this invention, the nature of the SNPs in the genetic target is determined by the steps of providing a plurality of hybridization complexes arrayed on a plurality of test sites on an electronically bioactive microchip, where the hybridization complex includes at least a nucleic acid target containing a SNP, a stabilizer probe having a sequence complementary to the target sequence and/or reporter probe, and a reporter probe having a selected sequence complementary to either the stabilizer or the same target sequence strand wherein a selected sequence of the reporter includes either a wild type nucleotide or a nucleotide corresponding to the SNP of the target.Type: ApplicationFiled: April 12, 1999Publication date: August 16, 2001Inventors: MICHAEL I. NERENBERG, DAVID M. CANTER, RAY R. RADTKEY, LING WANG, JAMES P. O'CONNELL
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Patent number: D739553Type: GrantFiled: March 15, 2013Date of Patent: September 22, 2015Assignee: Nanomix, Inc.Inventors: Jui-Ming Yang, Bradley N. Johnson, Ray R. Radtkey