Patents by Inventor Ray STAPLETON

Ray STAPLETON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTESTINAL ALKALINE PHOSPHATASE FORMULATIONS
    Publication number: 20230277466
    Abstract: The present invention provides for a formulation comprising an active alkaline phosphatase (AP)-based agent and an enteric agent, wherein the formulation is suitable for releasing a substantial amount of the active AP-based agent in the intestines.
    Type: Application
    Filed: March 17, 2023
    Publication date: September 7, 2023
    Inventors: Andrew BRISTOL, Ray STAPLETON, Michael KALEKO, Christian FURLAN FREGUIA, Steven HUBERT, Cristina FREIRE, James GUBBINS
  • Intestinal alkaline phosphatase formulations
    Patent number: 11638699
    Abstract: The present invention provides for a formulation comprising an active alkaline phosphatase (AP)-based agent and an enteric agent, wherein the formulation is suitable for releasing a substantial amount of the active AP-based agent in the intestines.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: May 2, 2023
    Assignee: Theriva Biologics, Inc.
    Inventors: Andrew Bristol, Ray Stapleton, Michael Kaleko, Christian Furlan Freguia, Steven Hubert, Cristina Freire, James Gubbins
  • ALKALINE PHOSPHATASE FORMULATIONS AND USES THEREOF
    Publication number: 20220323367
    Abstract: The present invention provides, in part, formulations comprising an alkaline phosphatase. Particularly, modified-release formulations comprising an alkaline phosphatase are provided, which release a substantial amount of the alkaline phosphatase in the intestines. Therapeutic uses of the alkaline phosphatase formulations are also provided.
    Type: Application
    Filed: June 3, 2020
    Publication date: October 13, 2022
    Inventors: Michael KALEKO, Ray STAPLETON, Andrew BRISTOL, Steven HUBERT, Cristina FREIRE
  • INTESTINAL ALKALINE PHOSPHATASE FORMULATIONS
    Publication number: 20210030686
    Abstract: The present invention provides for a formulation comprising an active alkaline phosphatase (AP)-based agent and an enteric agent, wherein the formulation is suitable for releasing a substantial amount of the active AP-based agent in the intestines.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 4, 2021
    Inventors: Andrew BRISTOL, Ray STAPLETON, Michael KALEKO, Christian FURLAN FREGUIA, Steven HUBERT, Cristina FREIRE, James GUBBINS