Patents by Inventor Raya Mandler

Raya Mandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water-soluble drugs and methods for their production
    Patent number: 7026350
    Abstract: The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of producing water-soluble analogues of water-insoluble drugs through derivatization and conjugation with a polar moiety via a thiol ether bond with a heterobifunctional linking molecule.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: April 11, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David K. Ho, Raya Mandler, Ada Belinda Alvarado-Lindner, Kaye B. Dillah Upadhyay, David J. Newman
  • Water-soluble drugs and methods for their production
    Publication number: 20040204395
    Abstract: The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of producing water-soluble analogues of water-insoluble drugs through derivatization and conjugation with a polar moiety via a thiol ether bond with a heterobifunctional linking molecule.
    Type: Application
    Filed: May 3, 2004
    Publication date: October 14, 2004
    Applicant: Government of the United States of America, Department of Health and Human Services
    Inventors: David K. Ho, Raya Mandler, Ada Belinda Alvarado-Lindner, Kaye B. Dillah Upadhyay, David J. Newman
  • Water-soluble drugs and methods for their production
    Patent number: 6747055
    Abstract: The present invention provides water-soluble drugs, in particular, water-soluble analogues of geldanamycin, and compositions comprising the same. This invention also provides a method of rendering water-soluble drugs soluble in water through derivatization with a bifunctional linking molecule and subsequent conjugation to a polar moiety through a thio ether. The present invention ether provides a method of treating cancer in a mammal.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: June 8, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David K. Ho, Raya Mandler, Ada Belinda Alvarado-Lindner, Kaye B. Dillah Upadhyay, David J. Newman