Patents by Inventor Raymond A. Firestone

Raymond A. Firestone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CONTRACEPTION
    Publication number: 20150335761
    Abstract: The invention generally relates to novel compounds, compositions, devices and methods for contraception. More particularly, the invention relates to cytotoxic agents and di-peptide conjugated contraceptive agents, methods for their preparation, pharmaceutical compositions, devices and uses thereof, especially in the prevention of pregnancy.
    Type: Application
    Filed: January 1, 2013
    Publication date: November 26, 2015
    Inventor: Raymond Firestone
  • COMPOSITIONS AND METHODS FOR TREATING CANCER AND INFLAMMATION-RELATED DIESEASES AND CONDITIONS
    Publication number: 20140364359
    Abstract: The invention provides di-peptide conjugated antitumor agents, pharmaceutical compositions and methods for preparation and use thereof for treating various cancer and inflammation-related diseases and conditions. The present invention addresses the shortcomings of the existing anti-tumor and anti-inflammatory drugs, particularly in that the anti-tumor agents of the invention that selectively kill cancer cells with minimal damage to normal cells.
    Type: Application
    Filed: January 17, 2013
    Publication date: December 11, 2014
    Inventor: Raymond A FIRESTONE
  • Enzyme-activated anti-tumor prodrug compounds
    Patent number: 6855689
    Abstract: Disclosed are enzyme-activated anti-tumor and anti-metastatic prodrug compounds. The specific enzymes are collagenase(IV) and elastase. Also disclosed are methods of making and using such compounds.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: February 15, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Raymond A. Firestone, Leila A. Telan
  • Branched peptide linkers
    Patent number: 6759509
    Abstract: Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: July 6, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Dalton King, Raymond A. Firestone, Gene M. Dubowchik
  • FAP-activated anti-tumour compounds
    Patent number: 6613879
    Abstract: The invention relates to a prodrug that is capable of being converted into a drug by the catalytic action of human fibroblast activation protein (FAP&agr;), said prodrug having a cleavage site which is recognised by FAP&agr;, and said drug being cytotoxic or cytostatic under physiological conditions.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: September 2, 2003
    Assignees: Boehringer Ingelheim Pharma KG, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Raymond A. Firestone, Wolfgang J. Rettig, Martin Lenter, Stefan Peters, Pilar Garin-Chesa, Juergen Mack, Dietmar Leipert, John E. Park, Leila A. Telan
  • Branched hydrazone linkers
    Patent number: 6512101
    Abstract: Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: January 28, 2003
    Assignee: Bristol Myers Squibb Company
    Inventors: Dalton King, Raymond A. Firestone, Pamela Trail
  • Enzyme-activated anti-tumor prodrug compounds
    Publication number: 20020147138
    Abstract: Disclosed are enzyme-activated anti-tumor and anti-metastatic prodrug compounds. The specific enzymes are collagenase(IV) and elastase. Also disclosed are methods of making and using such compounds.
    Type: Application
    Filed: May 23, 2002
    Publication date: October 10, 2002
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Raymond A. Firestone, Leila A. Telan
  • Method for treating tumors having high LDL requirements employing MTP inhibitors
    Patent number: 5990110
    Abstract: A method is provided for treating hematologic tumors and solid tumors, including certain types of leukemias and metastatic tumors, having high LDL requirements employing a delipidating agent such as an MTP inhibitor to substantially reduce LDL blood levels. In addition, a method is provided for treating tumors of the above types having high LDL requirements, especially hematologic tumors such as certain leukemias, employing a delipidating compound to substantially remove native LDL, and then administering a cytotoxic agent carried in reconstituted LDL.
    Type: Grant
    Filed: July 15, 1997
    Date of Patent: November 23, 1999
    Assignee: Bristol-Meyers Squibb Company
    Inventor: Raymond A. Firestone
  • Branched hydrazone linkers
    Patent number: 5824805
    Abstract: Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: October 20, 1998
    Inventors: Dalton King, Raymond A. Firestone, Pamela Trail
  • Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
    Patent number: 5364848
    Abstract: New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Raymond A. Firestone, Paul E. Finke, William K. Hagmann, Shrenik K. Shah, Kevan R. Thompson
  • Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
    Patent number: 5132301
    Abstract: New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Raymond A. Firestone, Paul E. Finke, William K. Hagmann, Shrenik K. Shah, Kevan R. Thompson
  • Allylsulfoxide enzyme inhibitors
    Patent number: 4760067
    Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: July 26, 1988
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • Lysosometropic detergent therapeutic agents
    Patent number: 4719312
    Abstract: The present invention is concerned with the preparation of lysosomotropic detergent agents and pharmaceutical composition useful in the treatment of cancer. These compounds are amine derivatives having a pK of 3.5 of the general structure ##STR1## in which R.sub.1 is C.sub.8-30 alkyl, C.sub.8-30 -alkenyl, substituted C.sub.4-30 alkyl or substituted C.sub.4-30 -alkenyl; R.sub.2 is hydrogen or C.sub.1-4 alkyl and Y is an electron withdrawing group, to control the pK, selected from trifluoroethyl, and difluoroethyl.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: January 12, 1988
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • Substituted azetidinones as anti-inflammatory and antidegenerative agents
    Patent number: 4680391
    Abstract: New substituted azetidinones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: April 10, 1985
    Date of Patent: July 14, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Raymond A. Firestone, Peter L. Barker
  • Allylsulfoxide enzyme inhibitors
    Patent number: 4670470
    Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: June 2, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • Allylsulfoxide enzyme inhibitors
    Patent number: 4654359
    Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: March 31, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • Substituted cephalosporins as anti-inflammatory and antidegenerative agents
    Patent number: 4637999
    Abstract: Substituted cephalosporins are found to be potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 2, 1983
    Date of Patent: January 20, 1987
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Paul E. Finke, Raymond A. Firestone, Shrenik S. Shah, Kevan R. Thompson
  • Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
    Patent number: 4623645
    Abstract: Substituted cephalosporin sulfoxides are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: November 18, 1986
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Bonnie M. Ashe, Paul E. Finke, Raymond A. Firestone, Shrenik K. Shah, Morris Zimmerman
  • Sealing means for a vacuum distillation apparatus
    Patent number: 4569724
    Abstract: A sealing means for a vacuum distillation apparatus is provided having a vapor tube rotatably and sealably mounted within a vacuum tube through which vapor passes.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: February 11, 1986
    Inventor: Raymond A. Firestone
  • Allylsulfoxide enzyme inhibitors
    Patent number: 4564635
    Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.
    Type: Grant
    Filed: October 23, 1984
    Date of Patent: January 14, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone