Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A lighting driver includes a negative third harmonic generator configured to generate a negative third harmonic signal corresponding to a third harmonic of an AC input voltage shifted by 180 degrees. The lighting driver further includes an adder circuit configured to generate an adder output signal by adding the negative third harmonic signal to a voltage divider output signal generated from the AC input voltage. The lighting driver also includes a controller configured to control generation of a DC output voltage provided by the lighting driver based on a control signal generated from the adder output signal.

Abstract: Systems and methods are provided for drying plant material using molecular sieves.

Abstract: A method of forming and assembling a foldable plastic utility enclosure using molds to form sides of the enclosure, preferably using glass fiber-reinforced thermoplastic composite. The molds are constructed to form a central hole in hinge members which are formed on ends of the sides. The central hole of the hinge member is molded with two molding parts, wherein one or both of the molding parts have a solid central portion that forms the central hole. The sides are removed from the molds after curing and the sides are assembled to form the utility enclosure while the sides are still hot from the molding process. Hinge pins are inserted into the central holes of the hinge members to form hinges and to prevent the sides from warping during cooling. Assembling the sides and inserting hinge pins to form the utility enclosure is completed within approximately 10 minutes after removing the sides from the molds.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A lid for a utility enclosure having a front end, a rear end, a right side, a left side, a top lid portion, and a bottom, defining an interior. Large reinforcement ribs are on an interior surface of the top lid portion and form a lattice-type structure. Small reinforcement ribs are mounted in spaces formed by the lattice type structure. The lid is made of glass fiber-reinforced polypropylene and metal bars or rebar are embedded in the large reinforcement ribs. The metal bars are positioned near a bottom of the large reinforcement ribs and spaced above the bottom. The physical structure of the lid and the lid's composition, consisting essentially of glass fiber-reinforced polypropylene, are constructed so that the lid withstands up to 33,750 pounds of force without breaking or being deformed.

Abstract: A lid for a utility enclosure having a front end, a rear end, a right side, a left side, a top lid portion, and a bottom, defining an interior. Large reinforcement ribs are on an interior surface of the top lid portion and form a lattice-type structure. Small reinforcement ribs are mounted in spaces formed by the lattice type structure. The lid is made of glass fiber-reinforced polypropylene and metal bars or rebar are embedded in the large reinforcement ribs. The metal bars are positioned near a bottom of the large reinforcement ribs and spaced above the bottom. The physical structure of the lid and the lid's composition, consisting essentially of glass fiber-reinforced polypropylene, are constructed so that the lid withstands up to 33,750 pounds of force without breaking or being deformed.

Abstract: A foldable extension enclosure for a utility enclosure, each having first, second, third, and fourth sides connected by hinges and each folding only in one direction by means of detents on the sides. A first end of the first side slidably overlaps a second opposite end of the third side and a first end of the second side slidably overlaps a second opposite end of the fourth side. There is an internal top ledge on each side in an interior near a top end of the extension enclosure and the utility enclosure and an external bottom ledge on each side on an exterior near a bottom end of the extension enclosure, to mount the extension enclosure to the utility enclosure with concave and convex detents. Convex detents are at the top end of the utility and extension enclosures and concave detents are at the bottom end of the extension enclosure. The convex detents also reversibly lock a lid to the tops of the utility and extension enclosures.

Abstract: A lighting fixture includes a light source that emits an illumination light and a receiver configured to receive a lighting control message from a photo sensor device. The lighting fixture further includes a lighting controller configured to adjust the illumination light based on the lighting control message. Adjusting the illumination light by the lighting controller includes changing a Correlated Color Temperature (CCT) of the illumination light.

Abstract: The presently claimed invention relates to a polymer emulsion and a process for preparing a polymer emulsion. Particularly, the presently claimed invention relates to a process for preparing a polymer emulsion with high solids content.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A lighting system having a main direct current (DC) voltage source and controllable lighting fixtures that each have a DC-DC current source. Each lighting fixture includes a DC voltage to current converter and an LED light source, and the DC voltage to current converter outputs a constant current from the DC voltage provided by a AC-to-DC converter. The output current of the DC voltage to current converter is independent of the total number of lighting fixtures in the lighting system and is controlled by injecting control commands to the DC voltage provided to DC-DC current source, wherein the AC power provided to the AC-to-DC converter is turned on and off to turn on and off the lights provided by the lighting fixtures of the lighting system and dimming and/or other lighting controls by injecting control commands into the DC voltage provided to the DC-DC current source.

Abstract: A copolymer includes a hydrophobic head segment and a random copolymer tail segment comprising hydrophobic blocks and ionizable blocks. Emulsion polymerization systems incorporate the copolymer as a surfactant.

Abstract: A connection to releasably connect and disconnect to a pipe to a fitting provides a pipe fitting body for receiving a pipe and a retaining ring located within the fitting body for retaining and releasing the pipe. The retaining ring has axially extending resilient retaining tabs, each of which has a radially inwardly extending portion for engaging the pipe, and, a radially outwardly extending portion which extends through corresponding radial openings in the fitting body. When the pipe is inserted into the fitting body to an inserted position and the retaining ring is in the first locked axial position, the radially inwardly extending portions engage and retain the pipe in the inserted position.

Abstract: A foldable extension enclosure for a utility enclosure, each having first, second, third, and fourth sides connected by hinges and each folding only in one direction by means of detents on the sides. A first end of the first side slidably overlaps a second opposite end of the third side and a first end of the second side slidably overlaps a second opposite end of the fourth side. There is an internal top ledge on each side in an interior near a top end of the extension enclosure and the utility enclosure and an external bottom ledge on each side on an exterior near a bottom end of the extension enclosure, to mount the extension enclosure to the utility enclosure with concave and convex detents. Convex detents are at the top end of the utility and extension enclosures and concave detents are at the bottom end of the extension enclosure. The convex detents also reversibly lock a lid to the tops of the utility and extension enclosures.

Abstract: A lid for a utility enclosure having a front end, a rear end, a right side, a left side, a top lid portion, and a bottom, defining an interior. Large reinforcement ribs are on an interior surface of the top lid portion and form a lattice-type structure. Small reinforcement ribs are mounted in spaces formed by the lattice type structure. The lid is made of glass fiber-reinforced polypropylene and metal bars or rebar are embedded in the large reinforcement ribs. The metal bars are positioned near a bottom of the large reinforcement ribs and spaced above the bottom. The physical structure of the lid and the lid's composition, consisting essentially of glass fiber-reinforced polypropylene, are constructed so that the lid withstands up to 33,750 pounds of force without breaking or being deformed.

Abstract: A method of forming and assembling a foldable plastic utility enclosure using molds to form sides of the enclosure, preferably using glass fiber-reinforced thermoplastic composite. The molds are constructed to form a central hole in hinge members which are formed on ends of the sides. The central hole of the hinge member is molded with two molding parts, wherein one or both of the molding parts have a solid central portion that forms the central hole. The sides are removed from the molds after curing and the sides are assembled to form the utility enclosure while the sides are still hot from the molding process. Hinge pins are inserted into the central holes of the hinge members to form hinges and to prevent the sides from warping during cooling. Assembling the sides and inserting hinge pins to form the utility enclosure is completed within approximately 10 minutes after removing the sides from the molds.