Abstract: Disclosed herein are peptide-adjuvant pharmaceutical compositions and vaccine compositions that trigger long lasting natural anti-tumor antibodies. Such compositions may be used alone, or in combination with anti-cancer agents, chemotherapeutic agents, anti-PD therapy, chemotherapy, radiation therapy, and surgery, in the prevention and treatment of cancer.

Abstract: Disclosed herein are peptide-adjuvant pharmaceutical compositions and vaccine compositions that trigger long lasting natural anti-tumor antibodies. Such compositions may be used alone, or in combination with anti-cancer agents, chemotherapeutic agents, anti-PD therapy, chemotherapy, radiation therapy, and surgery, in the prevention and treatment of cancer.

Abstract: Featured herein are unique epitopes of human glioma pathogenesis-related protein 1 (hGLIPR-1), nucleic acids encoding the same; inhibitors of the nucleic acids and polypeptides; as well as methods for treating certain cancers and viral infections in a subject by administering to the subject an effective amount of a GLIPR1 inhibitor.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The present invention relates to anti-West Nile virus E protein (WNE) antibodies, including human antibodies, and antigen-binding portions thereof. In particular, the invention relates to such antibodies and portions that prevent, inhibit, or treat a flavivirus infection, including a West Nile Virus infection. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or that are portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-WNE antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-WNE antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis, prophylaxis and treatment.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The material compactor generally includes a feed apparatus and a final compaction apparatus. The final compaction apparatus generally includes a compaction chamber having confronting compression plates and an adjustably taperable portion. The area of the inner cavity of the final compaction chamber can be adjusted to become measurably smaller (tapered) or larger at the opened discharge or expelling end. Consequently, compacting movement of the material within the compaction chamber and through the chamber significantly subjects the material to restrictive compacting pressure which in turn compacts the material and performs liquid separation with each operationally continuous movement through the final compaction apparatus and out an open discharge port.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The material compactor generally includes a feed apparatus and a final compaction apparatus. The final compaction apparatus generally includes a compaction chamber having confronting compression plates and an adjustably taperable portion. The area of the inner cavity of the final compaction chamber can be adjusted to become measurably smaller (tapered) or larger at the opened discharge or expelling end. Consequently, compacting movement of the material within the compaction chamber and through the chamber significantly subjects the material to restrictive compacting pressure which in turn compacts the material and performs liquid separation with each operationally continuous movement through the final compaction apparatus and out an open discharge port.

Abstract: The present invention reveals a class of novel inhibitors of metalloproteinase. For convenience, these polypeptides are referred to as “TIMP-3”, as these polypeptides represent a new class of members of the tissue inhibitors of metalloproteinases. Also provided are DNA sequences coding for all or part of the TIMP-3s, vectors containing such DNA sequences, and host cells transformed or transfected with such vectors. In addition, methods of producing recombinant TIMP-3s, methods of treating disorders, pharmaceutical compositions including TIMP-3s and antibodies selectively binding TIMP-3s are provided.

Abstract: This application is directed to compositions and methods comprising isolated and purified West Nile virus polypeptides and immunogenic fragments thereof, nucleic acid molecules encoding them and antibodies specific for such polypeptides or fragments. Such polypeptides and fragments, fusion proteins comprising them and antibodies are useful as vaccines to treat, inhibit or prevent West Nile virus infection or disease, to detect West Nile virus infection and to monitor the course of disease or immunization.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.

Abstract: Anti-p185HER-2/neu antibodies which are useful in the detection of HER-2/neu oncogene overexpression in biological samples are described. The antibodies are accurate and reliable in immunocytochemical or immunohistochemical assays of cell and tissue samples. Also described are methods for detecting HER-2/neu oncogene expression in a biological sample using the antibodies of the invention and a diagnostic kit comprising the antibodies. The reagents provide an accurate means of identifying certain cancer patients who have the greatest probability of relapse and/or the least likelihood of survival.

Abstract: Anti-p185.sup.HER-2/neu antibodies which are useful in the detection of HER-2/neu oncogene overexpression in biological samples are described. The antibodies are accurate and reliable in immunocytochemical or immunohistochemical assays of cell and tissue samples. Also described are methods for detecting HER-2/neu oncogene expression in a biological sample using the antibodies of the invention and a diagnostic kit comprising the antibodies. The reagents provide an accurate means of identifying certain cancer patients who have the greatest probability of relapse and/or the least likelihood of survival.