Patents by Inventor Raymond A. Petryshyn

Raymond A. Petryshyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double-stranded RNA dependent protein kinase derived peptides to promote proliferation of cells and tissues in a controlled manner
    Patent number: 6326466
    Abstract: This invention relates to double-stranded RNA dependent protein kinase (PKR) peptide antagonists. More specifically, the invention relates to compositions and methods for antagonizing activation of double-stranded RNA dependent protein kinase (PKR) to stimulate eukaryotic cell proliferation. The invention relates to compositions and methods to inhibit activation of double-stranded RNA dependent protein kinase (PKR) to stimulate cell proliferation under conditions of cell cycle arrest, quiescence, reduced growth or cell death. The invention also relates to methods of protecting cells from HIV-1 pathogenesis using inhibitors of PKR.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: December 4, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Raymond Petryshyn
  • Cell growth-controlling oligonucleotides
    Patent number: 6124091
    Abstract: The present invention provides a partial cDNA corresponding to an RNA containing double stranded regions (R-RNA), which, when transcribed in vitro, gives rise to an RNA transcript that activates PKR. An approximately 226-252 bp nucleotide (nt) sequence responsible for activation of PKR (the activation sequence) has been identified within the cDNA and isolated. Antisense oligonucleotides corresponding to specific portions of the 252 nt cDNA fragment stimulate proliferation of different cells in culture. Various portions of the cDNA or R-RNA may also be used to inhibit cell proliferation in cell cultures.The present invention further provides pharmaceutical compositions comprising the subject nucleic acid fragments and oligonucleotides. Kits which comprise at least one of the subject isolated nucleic acid molecules or oligonucleotides and a pharmaceutically acceptable carrier are also provided.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: September 26, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Raymond A. Petryshyn