Abstract: A power bucket having a first and second bucket half pivotally secured together about a main axis by a pivot pin. The bucket halves are movable between an open and a closed position. A head is disposed above the bucket halves and at least one arm pivotally connects the head to one bucket half while at least one second arm is pivotally connected between the head and the other bucket half. A cylinder support is pivotally mounted to the pivot pin and one end of a hydraulic cylinder is attached to the pivot support. The other end of the cylinder is attached to the bucket. Upon actuation of the cylinders, the cylinders move the bucket halves so that a cutting edge of the bucket half moves in a substantially horizontal plane.

Abstract: A power bucket having a first and second bucket half pivotally secured together about a main axis by a pivot pin. The bucket halves are movable between an open and a closed position. A head is disposed above the bucket halves and at least one arm pivotally connects the head to one bucket half while at least one second arm is pivotally connected between the head and the other bucket half. A cylinder support is pivotally mounted to the pivot pin and one end of a hydraulic cylinder is attached to the pivot support. The other end of the cylinder is attached to the bucket. Upon actuation of the cylinders, the cylinders move the bucket halves so that a cutting edge of the bucket half moves in a substantially horizontal plane.

Abstract: A power bucket having a first and second swing arm, each having two ends. The first end of each swing arm are pivotally secured together. A first bucket half is then pivotally secured to the other end of the swing arm and, likewise, a second bucket half is pivotally mounted to the second swing arm and the bucket halves are in turn pivotally secured together. A first and second hydraulic actuator are operatively connected between the first swing arm and the first bucket half and the second swing arm and the second bucket half, respectively. The hydraulic rods for the actuators are movable between a retracted position in which the bucket is open, and an extended position in which the bucket is closed.

Abstract: A power bucket having a first and second swing arm, each having two ends. The first end of each swing arm are pivotally secured together. A first bucket half is then pivotally secured to the other end of the swing arm and, likewise, a second bucket half is pivotally mounted to the second swing arm and the bucket halves are in turn pivotally secured together. A first and second hydraulic actuator are operatively connected between the first swing arm and the first bucket half and the second swing arm and the second bucket half, respectively. The hydraulic rods for the actuators are movable between a retracted position in which the bucket is open, and an extended position in which the bucket is closed.

Abstract: A method of chemically resecting the exocrine portion of the pancreas of a patient in need thereof comprising administering to the patient an amount of a hydroxy polyamine or a salt thereof with a pharmaceutically acceptable acid sufficient to resect the exocrine portion of the pancreas thereof, but insufficient to substantially alter the endocrine portion thereof. The hydroxy polyamine has a structure according to the formula: wherein: R1 and R2 may be the same or different and are alkyl having 1 to 6 carbon atoms or aryl or aralkyl having up to 12 carbon atoms; a, b, d and e may be the same or different and are integers from 1 to 4; and c is an integer from 2 to 6. A pharmaceutical composition in unit dosage form comprising the hydroxy polyamine or a salt thereof with a pharmaceutically acceptable acid for use in the method of the invention is also disclosed.

Abstract: Many metal chelators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyamine-metal chelator conjugates of the invention are compounds comprising a first moiety which is a metal chelator and a second moiety which is a polyamine, where the polyamine moiety includes three or more nitrogen atoms which are capable of being positively charged at physiological pH. A spermine-L1 conjugate has been shown to accumulate in L1210 cells several hundred fold more than the unconjugated L1 chelator.

Abstract: The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.

Abstract: Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically-effective amount of a compound of formula (I) or (IV), i.e. sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labeling for treating malaria. The substituents are detailed in the specification.

Abstract: The disclosure provides methods for treating hepatocellular carcinoma. The methods include administering to a subject an effective amount of DENSPM to treat the hepatocellular carcinoma.

Abstract: Many metal collators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyimide-metal collator conjugates of the invention are compounds comprising a first moiety which is a metal collator and a second moiety which is a polyimide, where the polyimide moiety includes three or more nitrogen atoms which are capable of being positively charged at physiological pH. A sperms-L1 conjugate has been shown to accumulate in L1210 cells several hundred fold more than the unconjugated L1 chelator.

Abstract: Compounds represented by structural formulas such as Structural Formula (I): are highly efficient in clearing excess iron from an organism. The invention also discloses methods of treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

Abstract: A method and pharmaceutical composition for ameliorating pain in a human or non-human mammal suffering therefrom based on an antinociceptive amine having the formula: wherein: Z is H or OH, is phenyl or cyclohexyl, R and R1 are the same or different and may be H or linear or branched chain alkyl having 1 to 8 carbon atoms, m is an integer from 0 to 10, inclusive and wherein the amine exhibits a mean reduction in abdominal writhings exhibited by mice in the standard acetic acid-induced visceral pain mouse model of at least 20%; a mixture of the amines; a derivative, salt or complex of the amine wherein the derivative, salt or complex former is physiologically acceptable and the formation of said salt, derivative or complex does not materially affect the pain amelioration properties of the amine; a mixture of the derivatives, salts and/or complexes or a prodrug that provides the amine, mixture of the amines, the derivative, salt or complex, or a mixture of the derivatives, salts and/or complexes.

Abstract: An aminated polyamine having the formula: or its possible stereoisomers or a salt thereof with a pharmaceutically acceptable acid wherein: R1 and R4 may be the same or different and are alkyl, aryl, aryl alkyl or cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom; R2 and R3 may be the same or different and are R1, R4 or H; N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's; ALK1, ALK2 AND ALK3 may be the same or different and are straight or branched chain alkylene bridging groups having 1 to 4 carbon atoms which effectively maintain the distance between the nitrogen atoms such that the polyamine: (i) is capable of uptake by a target cell upon administration of the polyamine to a human or non-human animal or is capable of binding to at least one polyamine site of a receptor located within or on the surface of a cell upon administration of the polyamine to a human or non-human animal; and (ii) upon uptake by the target cell, com

Abstract: Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically-effective amount of a compound of formula (I) or (IV), i.e. sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labeling for treating malaria. The substituents are detailed in the specification.

Abstract: Free radicals and reactive oxygen species have the potential to damage a wide variety of organic molecules, typically by oxidizing certain moieties. These damaging species can, for example, be produced by an organism as a by-product of cellular respiration or by the reaction of iron(II) and peroxide. The present invention includes methods of using aryl-substituted heterocyclic iron chelating compounds as antioxidants, as well as preventing the reduction of iron(III) to iron(II). In addition, the present invention provides methods of treating conditions such as inflammatory disease, neoplastic disease, and ischemic episodes.

Abstract: A composition, method and article of manufacture for the amelioration of pain comprising: a polyamine having the formula: R1R2N1—A—[N2R3—B]a—[N3R4—C]b—N4R5R6 wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chains interrupted by at least one etheric oxygen atom, or hydrogen; N1-N4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 0 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamine: (i) is capable of uptake by a target cell upon administration of the polyamine to a human or non-human animal; and (ii) upon uptake by the target cell, competitively binds via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intra-cellular natural polyamines in the target cell; the polyamine, u

Abstract: Pharmaceutical compositions for the treatment of hypertension comprising an effective anti-hypertensive amount of at least one compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound having one of the formulae (I), (II), (III) or (IV), and methods for the treatment of hypertension or effecting anti-hypertensive action which comprises administering to a patient requiring anti-hypertensive therapy or effect at least one of the above-described compounds.

Abstract: The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.

Abstract: A method for treating a human or non-human animal afflicted with malignant cells sensitive to vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of vibriobactin effective to inhibit the proliferation of the malignant cells.

Abstract: A bucket for a power shovel is disclosed which includes a first and second bucket half. Each bucket half includes a pair of elongated pivot arms having a scoop secured to one end of the pivot arm. The scoop includes spaced apart front and back walls, a bottom wall and a generally horizonal cutting edge which extends along one edge of the bottom wall between the front and back walls. The other ends of the pivot arms on one bucket half are pivotally secured to the pivot arms on the other bucket half so that the bucket halves are movable between an open position and a closed position. In the closed position, the open sides of the bucket halves register with each other to contain cargo within the interior of the bucket whereas, in their open position, the open ends and the digging edges of the bucket are spaced apart from each other. A head is disposed above the bucket halves and is secured to the bucket halves by cables which extend from the head and to each scoop.