Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: The present invention relates to devices, system and method for detecting gestures. The devices, systems and methods uses optically shape sensing devices for tracking and monitoring users. This allows unhindered, robust tracking of persons in different setting. The devices, systems and methods are especially useful in health care institutions.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: A medical system for imaging includes a processor (114) and memory (116) coupled to the processor. The memory includes an optical shape sensing module (115) configured to receive shape sensing data from a shape sensing system (104) coupled to a medical instrument (102). The shape sensing system is configured to measure a shape and position of the medical instrument. An image generation module (148) is configured to detect and digitally remove image artifacts of the medical instrument from a generated image based on at least the shape and the position of the medical instrument as measured by the shape sensing system.

Abstract: A method of simultaneously cleaning inorganic and organic contaminants from semiconductor wafers and micro-etching the semiconductor wafers. After the semiconductor wafers are cut or sliced from ingots, they are contaminated with cutting fluid as well as metal and metal oxides from the saws used in the cutting process. Aqueous alkaline cleaning and micro-etching solutions containing alkaline compounds and mid-range alkoxylates are used to simultaneously clean and micro-etch the semiconductor wafers.

Abstract: A method, system, and program product hold and manipulate tools during an intervention procedure. The device comprises: a holder body in fixed attachment with a shape-sensing fiber optic fiber; one of a plurality of tools being held by the holder body in coupled alignment with the shape-sensing fiber optic fiber.

Abstract: A fiber twist reduction system for optical shape sensing enabled instruments includes a rotatable launch fixture (12) configured to hold an optical fiber (28). An optical shape sensing enabled device (26) includes the optical fiber disposed therein. A rotation mechanism (14) is configured to rotate the fiber in response to a twist of the fiber to reduce accumulated twist along its length.

Abstract: A system for interventional brachytherapy for generating data to be used directly for therapy and/or for therapy planning includes a radiation source which irradiates tissue of a patient and one or more radiation detectors which detect radiation delivered to the patient and generate radiation dosage data indicative thereof. One or more position sensors determine the position of the radiation source and a localization unit, in communication with the one or more position sensors, generates position data indicative of the position of the radiation source. An image database stores one or more anatomical images of the patient.

Abstract: The disclosure is directed solutions and processes to remove substances from substrates. The substances can include photoresist. The solutions can include dimethylsulfoxide, a quaternary ammonium hydroxide, an alkanolamine, and less than 3% by weight water of a total weight of the solution. The quaternary ammonium hydroxide can include tetramethylammonium hydroxide, dimethyldipropylammonium hydroxide, or methyltriethylammonium hydroxide. Additionally, the solutions can include a secondary solvent. For example, the secondary solvent can include an alcohol. In another example, the secondary solvent can include ethylene glycol. Methods for the preparation and use of the solution to remove substances from substrates are also described.

Abstract: Some embodiments include a kit for increasing endurance of a battery-powered unmanned aerial vehicle (UAV) by incorporating flexible solar cells or applying flexible solar cells on a surface of a UAV or on a surface of a component of a UAV. The kit further include a power conditioning system configured to operate the solar cells within a desired power range and configured to provide power having a voltage compatible with an electrical system of the UAV.

Abstract: Methods for using improved stripper solutions having dimethyl sulfoxide; a quaternary ammonium hydroxide; an alkanolamine having at least two carbon atoms, at least one amino substituent and at least one hydroxyl substituent, with the amino and hydroxyl substituents being attached to two different carbon atoms; and a surfactant. Some formulation can additionally contain a secondary solvent. The stripper solutions are effective for removing photoresists from substrates, and typically have freezing points below about +15° C. and high loading capacities.

Abstract: A shape sensing system includes a guide tube (304) and an optical shape sensing device (104) including one or more optical fibers and being proximally fixed at a fixation point and being disposed within the guide tube. An interventional instrument (102) is rigidly attached to a handle (212) to prevent rotation of the instrument relative to the handle. The instrument has a lumen configured to receive the guide tube therein such that the optical shape sensing device is unconstrained throughout the instrument and the handle, and the guide tube is free to slip relative to at least rotation of the instrument and the handle without transferring torsional friction to optical shape sensing device.

Abstract: A method, system, and program product are provided for removing artifacts from an EM field generator from a rotational 3D scan. The method comprises: preoperatively, characterizing the artifacts from the EM field generator over a range of rotational positions of an x-ray source and detector; intraoperatively, determining the position of the EM field generator relative to the x-ray source and detector; and removing the preoperatively characterized artifacts for the determined relative position of the EM field generator from current x-ray image.

Abstract: A calibration/surgical tool includes an electromagnetic sensor array of two or more electromagnetic sensors in a known geometrical configuration. Electromagnetic tracking errors are characterized by a mapping of pre-operative absolute and relative errors based on a movement of a calibrated calibration/surgical tool through a pre-operative electromagnetic field. Using statistical mapping, a desired absolute error field is measured either in the clinic as the part of daily quality control checks, or before the patient comes in or in vivo. A resulting error field may be displayed to the physician to provide clear visual feedback about measurement confidence or reliability of localization estimates of the absolute errors in electromagnetic tracking.

Abstract: A training or rating system includes a shape sensing enabled device (104) and a database (140) of possible shapes and sequences of shapes for the shape sensing enabled device. The possible shapes and sequences of shapes include a collection of poses derived by appropriately performing a procedure with the shape sensing enabled device. A comparison module (154) is configured to compare real-time poses of the shape sensing enabled device with the collection of poses in the database to output comparison feedback for a user of the shape sensing enabled device.

Abstract: A volume mapping instrument (20), deployable within a partially or a completely enclosed anatomical volume, employs one or more medical tools (40) with each medical tool (40) being transitional between a deployable structural configuration to orderly position each medical tool (40) within the anatomical volume and a mapping structural configuration to anchor the medical tool (40) against the boundary of the anatomical volume. The volume mapping instrument (20) further employs an optical shape sensor (30) to generate one or more encoded optical signals indicative of a shape of the boundary of the anatomical volume in response to each medical tool (40) being transitioned from the deployable structural configuration to the mapping structural configuration within the anatomical volume. Based on the encoded optical signal(s), a volume mapping module (51) is utilized to map a portion or an entirety of the boundary of the anatomical volume.

Abstract: One embodiment of the present invention relates to a system for efficiently annotating numerous crash reports originating from multiple instances of an application. Prior to deploying a version of the application, a service receives a file that stores debugging information associated with the version. Next, the service parses the debugging information from the file. The service then converts the debugging information into an object representation in memory and stores the object representation in a database. Next, in response to an instance of the version crashing on a client device, the service receives a crash report from the client device. Then, for each item in the crash report, the service determines whether that item needs to be annotated and, if so, annotates the item.

Abstract: A shape sensing enabled instrument includes a flexible longitudinal body (300) including a plurality of longitudinal members (310) held together to form a lumen (205). The longitudinal members have frictional contact therebetween and are configured to engage neighboring longitudinal members during bending, twisting or external pressure to maintain dimensions of the lumen. A shape sensing optical fiber (302) is disposed within the lumen.

Abstract: A method and system for generating imaging data during a medical intervention are provided. An external optical sensor is attached on the patient's body, and includes at least one external orientation fiber core configured to measure an orientation of the external optical sensor relative to a point of reference. The external optical sensor is interrogated to generate external sensor orientation information during the medical intervention. That information is used to estimate an orientation of the external optical sensor, which is then displayed during the medical intervention.

Abstract: Improved dry stripper solutions for removing one, two or more photoresist layers from substrates are provided. The stripper solutions comprise dimethyl sulfoxide, a quaternary ammonium hydroxide, and an alkanolamine, a secondary solvent, and less than about 3 wt. % water. Methods for the preparation and use of the improved dry stripping solutions are additionally provided.