Abstract: Examples of the present disclosure describe systems and methods for zero trust domain name system (DNS) (ZTDNS) based networking. A computing device implementing ZTDNS based networking blocks any outbound connections that are not included in a list of trusted IP addresses. The list of trusted IP addresses is updated in response to the computing device receiving from a trusted DNS server an IP address corresponding to a DNS request. In some examples, the ZTDNS based networking intercepts and evaluates outbound communications for applications that implement a custom application DNS client. In other examples, the ZTDNS based networking intercepts and evaluates outbound communications for virtual environments. The outbound communications for both the custom application DNS client and the virtual environments are proxied through a local DNS client of the computing device.

Abstract: The present invention relates to a photochemical process for the manufacturing of a C-terminal ?-amide, which are a class of compounds that represent up to half of all biologically relevant peptide hormones. The invention provides mild, broad in scope, economically efficient process, which is suitable for large scale manufacturing.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: Ucn2 derivatives comprising a peptide and a substituent with high potency, high physical and high chemical stability, suitable for administration to humans, and their medical use in treatment and/or prevention of obesity and/or diabetes.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: Compounds and methods are provided for inhibiting a CREB-CBP protein-protein interaction in a sample. In some cases, the method includes modulating transcription of CREB in a cell that overexpresses CREB. Also provided are methods of inhibiting the proliferation of a cancer cell. The subject CREB transcription inhibitor compounds include a substituted salicylamide or a prodrug thereof. Methods of alleviating symptoms associated with cancer (e.g., Acute Myeloid Leukemia (AML) or Acute Lymphomblastic Leukemia (ALL)) in a subject in need thereof are also provided. Pharmaceutical compositions including the subject compounds find use in treating cancer. The subject compounds may be formulated or provided to a subject in combination with a second agent, e.g. an anticancer agent.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particularly the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH). The peptides comprise a lysine residue at a position corresponding to position 24 of hGIP(1-31), and comprise a negatively charged modifying group attached to the epsilon amino group of the lysine residue.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: A ladder support device removably securable to the hitch receiver of a vehicle. The ladder support device comprises a frame having adjustable ground engaging legs. The frame includes a pivoting arm to be removably secured to the hitch of a vehicle to allow the frame to be positioned in a desired orientation relative to the vehicle. The frame includes a pair of brackets for receiving the feet of an extension ladder therein. Further, the frame comprises a pair of telescopic support arms that extend upward from the frame and that can be secured to a portion of the extension ladder so as to secure the ladder in an upright, angled orientation without having to rest the ladder against a support surface, such as the side of a building.

Abstract: A ladder support device removably securable to the hitch receiver of a vehicle. The ladder support device comprises a frame having adjustable ground engaging legs. The frame includes a pivoting arm to be removably secured to the hitch of a vehicle to allow the frame to be positioned in a desired orientation relative to the vehicle. The frame includes a pair of brackets for receiving the feet of an extension ladder therein. Further, the frame comprises a pair of telescopic support arms that extend upward from the frame and that can be secured to a portion of the extension ladder so as to secure the ladder in an upright, angled orientation without having to rest the ladder against a support surface, such as the side of a building.

Abstract: A traction unit capable of traversing and turning on surfaces that include compound curves like the surface of a sphere or are inverted like a ceiling. The traction unit includes a plurality of trucks operable to propel the unit across a surface and a plurality of adherence members operable to releasably secure the unit to the surface. In operation, the adherence members cyclically attach to and release from the surface as the trucks propel the unit across the surface. Within each cycle, after the unit has traveled a predetermined distance relative to an attached member, the member releases the surface and reattaches to the surface at a different point.

Abstract: A traction unit capable of traversing and turning on surfaces that include compound curves like the surface of a sphere or are inverted like a ceiling. The traction unit includes a plurality of trucks operable to propel the unit across a surface and a plurality of adherence members operable to releasably secure the unit to the surface. In operation, the adherence members cyclically attach to and release from the surface as the trucks propel the unit across the surface. Within each cycle, after the unit has traveled a predetermined distance relative to an attached member, the member releases the surface and reattaches to the surface at a different point.