Patents by Inventor Raymond E. Spier

Raymond E. Spier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell and vaccine production
    Patent number: 4080258
    Abstract: Production of cells and vaccines utilizing a multiplate propagator in which the fluid dynamics of the system can be controlled during the growth cycle and/or the harvesting conditions can be controlled by rapidly cooling the harvested vaccine or by using multiple harvests, with or without automated collection of the vaccine thereby producing cells and vaccines in significantly increased yields and at substantially reduced costs in comparison with presently utilized procedures.
    Type: Grant
    Filed: January 30, 1974
    Date of Patent: March 21, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier
  • Cell and vaccine production
    Patent number: 3976547
    Abstract: Cell growth surfaces having controlled surface topography which permits the optimization of the fit between the cells and the growth surface. These surfaces may be constructed from sintered or sputtered titanium, glass, ceramic, plastic, or stainless steel, or may consist of a substrate having microspheres adhered to the surface thereof.
    Type: Grant
    Filed: November 19, 1974
    Date of Patent: August 24, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier, Abner J. Schlabach
  • Process for production of vaccines
    Patent number: 3965258
    Abstract: Process for producing a live virus vaccine for the immunization of chickens against Marek's disease utilizing a multiplate machine.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: June 22, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Kenneth L. Posch, Clarence L. Baugh, Raymond E. Spier
  • Vaccine production
    Patent number: 3959074
    Abstract: A process for the controlled manufacture of cells and vaccines in which reproducable real time quantitative assays are utilized to ascertain the physical and chemical state of the system, in order to more efficiently manage the system, so that cell sheet formation may be determined and the vaccine may be harvested at its maximum titre, thereby resulting in significantly increased yields and decreased production costs.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: May 25, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. Miller, Raymond E. Spier, William J. McAleer
  • Process for production of vaccines
    Patent number: 3933585
    Abstract: A multiplate propagator for producing cells and vaccines having critical geometric properties such as ratio of plate diameter to internal tank diameter results in significantly increased yields at substantially reduced costs.
    Type: Grant
    Filed: May 31, 1974
    Date of Patent: January 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Raymond E. Spier, Kenneth L. Posch