Abstract: The present invention relates to novel cyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders. The inhibitor of an interleukin-23 receptor is cyclized by a disulfide bond between penicillamine, cysteine, homocysteine, or alpha methylcysteine residues at positions X4 and X9.

Abstract: The present invention relates to novel bicyclic peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: Systems and methods of managing documents associated with resources. The system includes a communication module, a processor, and a memory. The memory stores duplicate detection data and instructions that, when executed, configure the processor to: receive, via the communication module and from a client device, an image of the subject document; extract a document identifier from the image of the subject document; obtain a date associated with the subject document; determine that the subject document is unique by comparing a set of validation data values with the duplicate detection data; and in response to determining that the subject document is unique, transmit, to the client device, a provisional acceptance notification and provisionally allocate the resource associated with the subject document to a data record corresponding to a second identifier.

Abstract: A system for controlling power in a facility having an electrical system including a generator and an associated fuel tank. The fuel tank provides fuel to the generator and has a gauge indicating remaining fuel. The generator is electrically connected to the electrical system. A first power consuming device imposes a first load connected to the electrical system of the facility and second power consuming device imposes a second load connected to the electrical system of the facility. The system receives information related to the loads and calculates an initial estimated run time of the generator given the remaining quantity of fuel and information related to the first load and information related to the second load. The system selectively removes the second load in a simulation and calculates a second run time of the generator given the remaining quantity of fuel and information related to the first load.

Abstract: A system for controlling power in a facility having an electrical system including a generator and an associated fuel tank. The fuel tank provides fuel to the generator and has a gauge indicating remaining fuel. The generator is electrically connected to the electrical system. A first power consuming device imposes a first load connected to the electrical system of the facility and second power consuming device imposes a second load connected to the electrical system of the facility. The system receives information related to the loads and calculates an initial estimated run time of the generator given the remaining quantity of fuel and information related to the first load and information related to the second load. The system selectively removes the second load in a simulation and calculates a second run time of the generator given the remaining quantity of fuel and information related to the first load.

Abstract: A user programmable dispenser is disclosed for dispensing and mixing soap, shampoo or other liquids from a container to a mixer to be mixed with water flowing to a shower spray nozzle. A touch screen LCD display connected to a programmable controller is used by the user to first program the amount of time that the soap, shampoo or other liquids is to flow through a valve and be mixed with the water flowing from the shower spray nozzle, then is used to temporarily interrupt and recommence the flow of liquid, and is also used to display the amount of time remaining for the flow of the soap, shampoo or other liquids from the container of the time initially programmed by the user for the flow of liquid from the container to the mixer.

Abstract: The apparatus, which can be used in aspirating face seals or thrust bearings, spaces two relatively rotatable facing surfaces in use by entraining gas between the surfaces. The apparatus includes a first portion (1) defining a generally frusto-conical surface (3); a second portion (2) defining at least one flat surface disposed adjacent the first portion so that the two surfaces face each other and define at least one point of closest engagement between the surfaces, with diverging gaps extending between the surfaces on either side of a plane which contains the point or points of closest engagement and which extends generally orthogonal to the direction of relative rotation, and a device (4) for biasing the flat surface towards the frusto-conical surface to maintain the gaps within a predetermined dimensional range.

Abstract: A composition for use in extracting metals from aqueous solutions of metals salts comprises at least one o-hydroxyaryloxime containing at least 5 aliphatic or alicyclic carbon atoms and at least one ester containing from 10 to 30 carbon atoms, the weight ratio of o-hydroxyaryloximes to the esters being in the range of 10:1 to 1:3. A process for extracting metal from aqueous solutions using the composition is also disclosed.

Abstract: The anti-shudder durability of power transmitting fluids, particularly automatic transmission fluids, is improved by incorporating a combination of alkyl phosphonates, ashless dispersants and metallic detergents.

Abstract: The invention provides synergistic combinations of phosphorus acid-containing compounds with ashless antioxidants. These combinations dramatically improve the oxidation stability of lubricating compositions, particularly power transmission fluids such as automatic transmission fluids.

Abstract: A composition for use in extracting copper values from aqueous solutions of metal salts comprises one or more o-hydroxyaryloximes containing at least 5 aliphatic or alicyclic carbon atoms which are strong metal extractants which, in 0.2 molar solution in an aliphatic hydrocarbon solution when loaded with 50% of the theoretical uptake of copper, will be in equilibrium with a 0.1 molar solution of copper as copper perchlorate at a pH less than 1 and one or more branched chain aliphatic or aliphatic-aromatic esters containing 10 to 30 carbon atoms, wherein the ratio of the number of methyl carbon atoms to the number of non-methyl carbon atoms is higher 1:5 and the weight ratio of A to B being in the range of 10:1 to 1:3.

Abstract: An improved power transmission fluid is formed which comprises a major amount of lubricating oil and an additive combination comprising (a) a viscosity modifier having a molecular weight no greater than about 175,000 atomic mass units, and (b) a selected friction modifier.

Abstract: A method of increasing the static coefficient of friction of an oleaginous composition, such as an ATF, comprising adding to a major portion of an oil of lubricating viscosity a friction increasing amount of an oil soluble friction increasing reaction product comprising (a) an oil soluble substituted or unsubstituted, saturated or unsaturated, branched hydrocarbyl group containing from about 12 to about 50 total carbon atoms, (b) a linking group, and (c) a nitrogen-containing polar group, wherein the polar group contains at least one nitrogen atom and, optionally, contains at least one atom selected from the group consisting of boron, oxygen and sulfur atoms, and wherein the polar group is linked to the branched hydrocarbyl group through the linking group.

Abstract: This invention provides a composition and method for producing partial synthetic automatic transmission fluids having improved shear-stability and low temperature properties without the need to incorporate polymeric viscosity modifiers.

Abstract: The frictional durability of lubricating oils, including power transmitting fluids and in particular automatic transmission fluids, are improved by incorporating a combination of low potency friction modifiers, ashless and/or metal-containing antioxidants, and oil-soluble phosphorus-containing compounds.

Abstract: An oil-soluble reaction product of phosphorus-, low molecular weight basic nitrogen-, and optional boron-containing compounds is provided. This reaction product can solubilize significantly more phosphorus and boron per weight of compound than other known compounds and is used as an antiwear, antioxidant, and extreme pressure additive in lubrication oils.

Abstract: This invention provides an oil-soluble complex of an oil-insoluble phosphorus-containing acid and an alcohol. This complex is a useful antiwear additive in lubricating oils, particularly automatic transmission fluids.

Abstract: The anti-shudder durability of power transmitting fluids, particularly automatic transmission fluids, is improved by incorporating a combination of low potency friction modifiers and phosphorus-containing compounds. The anti-shudder durability of these fluids may be further enhanced by inclusion of a metallic detergent and/or a polyol ester friction modifier.

Abstract: A process for extracting metal values, especially zinc values, from aqueous solutions of metal salts, which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula, ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom from a 5- to 8-membered heterocyclic ring.

Abstract: This invention provides a composition and method for producing partial synthetic automatic transmission fluids having improved shear-stability and low temperature properties without the need to incorporate polymeric viscosity modifiers.