Patents by Inventor Raymond George
Raymond George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12312396Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: GrantFiled: June 5, 2024Date of Patent: May 27, 2025Assignees: Theraclone Sciences, Inc., International AIDS Vaccine Initiative, Inc., The Scripps Research Institute.Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos, Stephen Kaminsky
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Patent number: 12121185Abstract: A locking mechanism (104) for a kitchen device (101) having a vessel (105), the vessel (105) providing an interior space and having a rim (106) surrounding an opening (105a) of the space, and a lid (121) to engage the rim (106) to close the space, the locking mechanism (104) comprising: a retaining arm (107), the retaining arm (107) being attachable to the device (101) and movable between a free position, wherein the lid (121) is movable with respect to the vessel (105), and a retaining position, wherein the retaining arm (107) is engageable with the lid (121) to retain the lid (121) against the vessel (105) to at least partly close the opening (105a); a securing assembly (108), the securing assembly (108) being attachable to the device (101) to engage the retaining arm (107) and movable between a free position, wherein the retaining arm (107) may be moved between the free position and the retaining position, and a securing position, wherein the securing assembly (108) engages the retaining arm (107) to preveType: GrantFiled: June 28, 2019Date of Patent: October 22, 2024Assignee: BREVILLE PTY LIMITEDInventors: Eddie Siu, Khon Thai, Bin Geng, Raymond George Corkin
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Publication number: 20240343782Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: June 5, 2024Publication date: October 17, 2024Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos, Stephen Kaminsky
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Publication number: 20240251893Abstract: An apparatus for providing a seal between a sleeve of a garment and a glove, the apparatus including a cuff body and a glove insert, the cuff body comprising a surrounding wall which defines an internal space, and the cuff body having a first distal open end and a second distal open end, the first distal open end comprising a resiliently deflectable sealing lip, which defines an opening of said first distal end, the glove insert is hollow and has a respective opening at each distal end, the glove insert comprises an outer surface which is provided with a locating channel which extends around the outer surface, the cuff body arranged for attachment to the sleeve of a garment, and the glove insert arranged to be inserted inside a glove, the sealing lip arranged to resiliently engage with glove material within the locating channel and thereby seal against the glove material.Type: ApplicationFiled: March 3, 2023Publication date: August 1, 2024Inventor: Raymond George CROSBY
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Patent number: 12048075Abstract: A lighting driver includes a negative third harmonic generator configured to generate a negative third harmonic signal corresponding to a third harmonic of an AC input voltage shifted by 180 degrees. The lighting driver further includes an adder circuit configured to generate an adder output signal by adding the negative third harmonic signal to a voltage divider output signal generated from the AC input voltage. The lighting driver also includes a controller configured to control generation of a DC output voltage provided by the lighting driver based on a control signal generated from the adder output signal.Type: GrantFiled: August 5, 2021Date of Patent: July 23, 2024Assignee: SIGNIFY HOLDING, B.V.Inventors: Raymond George Janik, Russel Scott Trask
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Patent number: 12018067Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: GrantFiled: January 6, 2023Date of Patent: June 25, 2024Assignees: International AIDS Vaccine Initiative, Inc., The Scripps Research Institute, Theraclone Sciences, Inc.Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos, Stephen Kaminsky
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Publication number: 20240132578Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: August 18, 2023Publication date: April 25, 2024Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
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Patent number: 11845789Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: GrantFiled: July 15, 2021Date of Patent: December 19, 2023Assignees: THERACLONE SCIENCES, INC., THE SCRIPPS RESEARCH INSTITUTE, INTERNATIONAL AIDS VACCINE INITIATIVE, INC.Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
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Publication number: 20230320277Abstract: Systems and methods are provided for drying plant material using molecular sieves.Type: ApplicationFiled: April 11, 2023Publication date: October 12, 2023Applicant: OPCIP-HOLDCO, LLCInventors: Stephen David Wobser, Raymond George Troyer
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Patent number: 11766834Abstract: A method of forming and assembling a foldable plastic utility enclosure using molds to form sides of the enclosure, preferably using glass fiber-reinforced thermoplastic composite. The molds are constructed to form a central hole in hinge members which are formed on ends of the sides. The central hole of the hinge member is molded with two molding parts, wherein one or both of the molding parts have a solid central portion that forms the central hole. The sides are removed from the molds after curing and the sides are assembled to form the utility enclosure while the sides are still hot from the molding process. Hinge pins are inserted into the central holes of the hinge members to form hinges and to prevent the sides from warping during cooling. Assembling the sides and inserting hinge pins to form the utility enclosure is completed within approximately 10 minutes after removing the sides from the molds.Type: GrantFiled: April 26, 2022Date of Patent: September 26, 2023Assignee: AFL Telecommunications LLCInventors: Dustin Kyle Nolen, Raymond George Thompson
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Publication number: 20230295278Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: January 6, 2023Publication date: September 21, 2023Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos, Stephen Kaminsky
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Publication number: 20230253767Abstract: A lid for a utility enclosure having a front end, a rear end, a right side, a left side, a top lid portion, and a bottom, defining an interior. Large reinforcement ribs are on an interior surface of the top lid portion and form a lattice-type structure. Small reinforcement ribs are mounted in spaces formed by the lattice type structure. The lid is made of glass fiber-reinforced polypropylene and metal bars or rebar are embedded in the large reinforcement ribs. The metal bars are positioned near a bottom of the large reinforcement ribs and spaced above the bottom. The physical structure of the lid and the lid's composition, consisting essentially of glass fiber-reinforced polypropylene, are constructed so that the lid withstands up to 33,750 pounds of force without breaking or being deformed.Type: ApplicationFiled: April 19, 2023Publication date: August 10, 2023Inventors: Dustin Kyle Nolen, Raymond George Thompson, Selvum Pillay
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Patent number: 11670917Abstract: A lid for a utility enclosure having a front end, a rear end, a right side, a left side, a top lid portion, and a bottom, defining an interior. Large reinforcement ribs are on an interior surface of the top lid portion and form a lattice-type structure. Small reinforcement ribs are mounted in spaces formed by the lattice type structure. The lid is made of glass fiber-reinforced polypropylene and metal bars or rebar are embedded in the large reinforcement ribs. The metal bars are positioned near a bottom of the large reinforcement ribs and spaced above the bottom. The physical structure of the lid and the lid's composition, consisting essentially of glass fiber-reinforced polypropylene, are constructed so that the lid withstands up to 33,750 pounds of force without breaking or being deformed.Type: GrantFiled: April 28, 2022Date of Patent: June 6, 2023Assignee: AFL Telecommunications LLCInventors: Dustin Kyle Nolen, Raymond George Thompson, Selvum Pillay
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Patent number: 11670918Abstract: A foldable extension enclosure for a utility enclosure, each having first, second, third, and fourth sides connected by hinges and each folding only in one direction by means of detents on the sides. A first end of the first side slidably overlaps a second opposite end of the third side and a first end of the second side slidably overlaps a second opposite end of the fourth side. There is an internal top ledge on each side in an interior near a top end of the extension enclosure and the utility enclosure and an external bottom ledge on each side on an exterior near a bottom end of the extension enclosure, to mount the extension enclosure to the utility enclosure with concave and convex detents. Convex detents are at the top end of the utility and extension enclosures and concave detents are at the bottom end of the extension enclosure. The convex detents also reversibly lock a lid to the tops of the utility and extension enclosures.Type: GrantFiled: June 3, 2022Date of Patent: June 6, 2023Assignee: AFL Telecommunications LLCInventors: Dustin Kyle Nolen, Selvum Pillay, Raymond George Thompson
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Patent number: 11665797Abstract: A lighting fixture includes a light source that emits an illumination light and a receiver configured to receive a lighting control message from a photo sensor device. The lighting fixture further includes a lighting controller configured to adjust the illumination light based on the lighting control message. Adjusting the illumination light by the lighting controller includes changing a Correlated Color Temperature (CCT) of the illumination light.Type: GrantFiled: March 19, 2021Date of Patent: May 30, 2023Assignee: SIGNIFY HOLDING B.V.Inventors: Raymond George Janik, Russell Scott Trask
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Patent number: 11584789Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: GrantFiled: October 28, 2020Date of Patent: February 21, 2023Assignees: INTERNATIONAL AIDS VACCINE INITIATIVE, INC., THE SCRIPPS RESEARCH INSTITUTE, THERACLONE SCIENCES, INC.Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos, Stephen Kaminsky
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Publication number: 20230027965Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: July 15, 2021Publication date: January 26, 2023Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
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Patent number: 11460134Abstract: A connection to releasably connect and disconnect to a pipe to a fitting provides a pipe fitting body for receiving a pipe and a retaining ring located within the fitting body for retaining and releasing the pipe. The retaining ring has axially extending resilient retaining tabs, each of which has a radially inwardly extending portion for engaging the pipe, and, a radially outwardly extending portion which extends through corresponding radial openings in the fitting body. When the pipe is inserted into the fitting body to an inserted position and the retaining ring is in the first locked axial position, the radially inwardly extending portions engage and retain the pipe in the inserted position.Type: GrantFiled: October 20, 2020Date of Patent: October 4, 2022Assignee: IPEX TECHNOLOGIES INC.Inventors: Jis Simon, Filippo Martino, Ivan Lee Stiehl, James Bruce Anthony Campbell, Raymond George Puache, Paul Agapito, Qing Li
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Publication number: 20220294193Abstract: A foldable extension enclosure for a utility enclosure, each having first, second, third, and fourth sides connected by hinges and each folding only in one direction by means of detents on the sides. A first end of the first side slidably overlaps a second opposite end of the third side and a first end of the second side slidably overlaps a second opposite end of the fourth side. There is an internal top ledge on each side in an interior near a top end of the extension enclosure and the utility enclosure and an external bottom ledge on each side on an exterior near a bottom end of the extension enclosure, to mount the extension enclosure to the utility enclosure with concave and convex detents. Convex detents are at the top end of the utility and extension enclosures and concave detents are at the bottom end of the extension enclosure. The convex detents also reversibly lock a lid to the tops of the utility and extension enclosures.Type: ApplicationFiled: June 3, 2022Publication date: September 15, 2022Inventors: Dustin Kyle Nolen, Selvum Pillay, Raymond George Thompson
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Patent number: D980628Type: GrantFiled: June 30, 2021Date of Patent: March 14, 2023Assignee: AFL Telecommunications LLCInventors: Dustin Kyle Nolen, Raymond George Thompson