Patents by Inventor Raymond J. Apple

Raymond J. Apple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and reagents for HLA DRbeta DNA typing
    Patent number: 5567809
    Abstract: Primers for amplification of specific nucleic acid sequences of the second exon of HLA DRbeta genes and probes for identifying polymorphic sequences contained in the amplified DNA can be used in processes for typing homozygous or heterozygous samples from a variety of sources and for detecting allelic variants not distinguishable by serological methods. This HLA DRbeta DNA typing system can be used in a dot-blot format that is simple and rapid to perform, produces detectable signals in minutes, and can be used for tissue typing, determining individual identity, and identifying disease susceptible individuals.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: October 22, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Raymond J. Apple, Henry A. Erlich, Robert L. Griffith, Stephen J. Scharf
  • Methods and reagents for HLA class I A locus DNA typing
    Patent number: 5451512
    Abstract: Primers for amplification of specific nucleic acid sequences of the second and third exon of HLA Class I A gene and probes for identifying polymorphic sequences contained in the amplified DNA can be used in processes for typing homozygous or heterozygous samples from a variety of sources and for detecting allelic variants not distinguishable by serological methods. This HLA-A DNA typing system can be used in a forward or reverse dot-blot format that is simple and rapid to perform, produces detectable signals in minutes, and can be used for tissue typing, determining individual identity, and identifying disease susceptible individuals.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: September 19, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Raymond J. Apple, Teodorica L. Bugawan, Henry A. Erlich