Patents by Inventor Raymond J. Bergeron
Raymond J. Bergeron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931346Abstract: Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a poly ether moiety at the 4?-position of the phenyl ring of the compound.Type: GrantFiled: May 14, 2021Date of Patent: March 19, 2024Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.
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Publication number: 20220105078Abstract: Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a poly ether moiety at the 4?-position of the phenyl ring of the compound.Type: ApplicationFiled: May 14, 2021Publication date: April 7, 2022Applicant: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, JR.
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Publication number: 20210322301Abstract: The present disclosure provides safe and effective dosing regimens of metal chelators as treatment for metal overload disorders and, in particular, iron overload and associated conditions.Type: ApplicationFiled: December 17, 2020Publication date: October 21, 2021Applicants: Abfero Pharmaceuticals, Inc., University of Florida Research Foundation, Inc.Inventors: Steven Keith BURKE, Raymond J. BERGERON
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Patent number: 10570104Abstract: The present invention provides compounds of Formula (I), which are “metabolically programmed” metal chelators, e.g., lipophilic, absorbable (e.g., orally absorbable), and effective metal chelators that are converted in vivo to their hydrophilic, nontoxic metabolites. The present invention also provides compounds of Formula (II), which are also “metabolically programmed” metal chelators. The invention also provides pharmaceutical compositions, kits, methods, and uses that include a compound described herein. The compounds, pharmaceutical compositions, kits, and methods may be useful in treating or preventing a disease (e.g., metal overload, oxidative stress, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, reperfusion injury, metal poisoning, or infectious disease).Type: GrantFiled: April 27, 2016Date of Patent: February 25, 2020Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.
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Publication number: 20180290990Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: ApplicationFiled: June 11, 2018Publication date: October 11, 2018Applicant: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, JR.
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Patent number: 10010535Abstract: Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary hemochromatosis, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, and reperfusion injury. The present invention provides methods and pharmaceutical compositions using desferrithiocin analogs of Formulae (A) and (J) for treating and/or preventing these pathological conditions, metal (e.g., iron, aluminum, a lanthanide, or an actinide (e.g., uranium)) overload conditions, and infectious diseases (e.g., malaria).Type: GrantFiled: November 21, 2014Date of Patent: July 3, 2018Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.
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Publication number: 20180161295Abstract: The present invention provides methods for treating closed head injuries or hemorrhagic strokes using a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) may act as iron chelators to prevent formation of highly reactive radicals leading to additional damage in the closed head injuries or hemorrhagic strokes.Type: ApplicationFiled: December 16, 2015Publication date: June 14, 2018Applicant: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, JR.
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Patent number: 9994535Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: GrantFiled: February 9, 2017Date of Patent: June 12, 2018Assignee: University of Florida Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Publication number: 20180140581Abstract: The present invention provides compounds of Formula (I), which are “metabolically programmed” metal chelators, e.g., lipophilic, absorbable (e.g., orally absorbable), and effective metal chelators that are converted in vivo to their hydrophilic, nontoxic metabolites. The present invention also provides compounds of Formula (II), which are also “metabolically programmed” metal chelators. The invention also provides pharmaceutical compositions, kits, methods, and uses that include a compound described herein. The compounds, pharmaceutical compositions, kits, and methods may be useful in treating or preventing a disease (e.g., metal overload, oxidative stress, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, reperfusion injury, metal poisoning, or infectious disease).Type: ApplicationFiled: April 27, 2016Publication date: May 24, 2018Applicant: University Of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, JR.
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Publication number: 20180036228Abstract: The present disclosure provides safe and effective dosing regimens of metal chelators as treatment for metal overload disorders and, in particular, iron overload and associated conditions.Type: ApplicationFiled: August 4, 2017Publication date: February 8, 2018Inventors: Steven Keith BURKE, Raymond J. BERGERON, JR.
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Patent number: 9730917Abstract: A relatively non-toxic desazadesferrithiocin analog having the formula: wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from 0 to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.Type: GrantFiled: October 5, 2015Date of Patent: August 15, 2017Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.
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Publication number: 20170217912Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: ApplicationFiled: February 9, 2017Publication date: August 3, 2017Applicant: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, JR.
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Publication number: 20170209420Abstract: Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a polyether moiety at the 4?-position of the phenyl ring of the compound.Type: ApplicationFiled: February 3, 2017Publication date: July 27, 2017Applicant: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, JR.
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Patent number: 9567309Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: GrantFiled: July 28, 2015Date of Patent: February 14, 2017Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Publication number: 20160289223Abstract: Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary hemochromatosis, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, and reperfusion injury. The present invention provides methods and pharmaceutical compositions using desferrithiocin analogs of Formulae (A) and (J) for treating and/or preventing these pathological conditions, metal (e.g., iron, aluminum, a lanthanide, or an actinide (e.g., uranium)) overload conditions, and infectious diseases (e.g., malaria).Type: ApplicationFiled: November 21, 2014Publication date: October 6, 2016Applicant: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, JR.
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Publication number: 20160022645Abstract: A relatively non-toxic desazadesferrithiocin analog having the formula: wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from 0 to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Applicant: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, JR.
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Publication number: 20150336911Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: ApplicationFiled: July 28, 2015Publication date: November 26, 2015Applicant: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, JR.
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Patent number: 9174948Abstract: A relatively non-toxic desazadesferrithiocin analog having the formula: wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from 0 to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.Type: GrantFiled: November 21, 2012Date of Patent: November 3, 2015Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 9125950Abstract: An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine.Type: GrantFiled: September 15, 2014Date of Patent: September 8, 2015Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 9096553Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.Type: GrantFiled: April 29, 2014Date of Patent: August 4, 2015Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.