Patents by Inventor Raymond J. Bowers

Raymond J. Bowers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS
    Publication number: 20140295403
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 2, 2014
    Applicant: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: R. Stephen BROWN, Samir P. TABASH, Igor S. KOZIN, Eric J.P. MARCOTTE, Arthur N. LEY, Kevin R. HALL, Moe HUSSAIN, Peter V. HODSON, Sr., Parveen AKHTAR, Raymond J. BOWERS, Robin A. WYNNE-EDWARDS, John G. ST. MARSEILLE
  • Detection of biological molecules by differential partitioning of enzyme substrates and products
    Patent number: 8632966
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: January 21, 2014
    Assignee: Queen's University at Kingston
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Detection of biological molecules by differential partitioning of enzyme substrates and products
    Patent number: 8377686
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: February 19, 2013
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Detection of biological molecules by differential partitioning of enzyme substrates and products
    Publication number: 20090117600
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: June 16, 2008
    Publication date: May 7, 2009
    Applicant: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J.P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, Parveen Akhtar, John G. St. Marseille
  • Detection of biological molecules by differential partitioning of enzyme substrates and products
    Patent number: 7402426
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: July 22, 2008
    Assignee: Queen's University at Kingston
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Parveen Akhtar, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • Detection of biological molecules by differential partitioning of enzyme substrates and products
    Publication number: 20040106164
    Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.
    Type: Application
    Filed: September 22, 2003
    Publication date: June 3, 2004
    Inventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J.P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Parveen Akhtar, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
  • N?N?-dichlorinated omega-amino acids and uses thereof
    Patent number: 6451761
    Abstract: A method of treating a CNS disorder in a subject in need of such treatment, the method comprising administering to the subject an effective amount of an N′N′-dichlorinated amino acid, peptide, peptidomimetic, amine, or a pharmacologically acceptable analogue or derivative thereof, such that a CNS disorder is treated. An N′N′-dichlorinated amino acid, peptide, peptidomimetic, or amine capable of crossing the blood-brain barrier of a subject when administered thereto.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: September 17, 2002
    Assignee: Queen's University at Kingston
    Inventors: Nico M. van Gelder, Raymond J. Bowers