Patents by Inventor Raymond J. H. Westheim

Raymond J. H. Westheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical tablets of crystalline type II aripiprazole
    Patent number: 8529949
    Abstract: Crystalline aripiprazole Type II can be formulated into pharmaceutical tablets having reduced dissolution profile variability upon storage.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: September 10, 2013
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua, Korinde Annemarie Jansen, Farid Abedin Dorkoosh
  • Hydrates of erlotinib hydrochloride
    Patent number: 8372856
    Abstract: Erlotinib hydrochloride hydrate is formed from an aqueous solution and is useful as a pharmaceutical and as a purification intermediate.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: February 12, 2013
    Assignee: Synthon BV
    Inventor: Raymond J. H. Westheim
  • Process of making crystalline type II aripiprazole
    Patent number: 8093387
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 10, 2012
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • Crystalline erlotinib
    Patent number: 7928114
    Abstract: Crystalline Forms of erlotinib are made. The crystalline materials are useful as pharmaceutical active agents in treating various cancers as well as in forming erlotinib salts.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: April 19, 2011
    Assignee: Synthon BV
    Inventor: Raymond J. H. Westheim
  • Process of making crystalline type II aripiprazole
    Publication number: 20100196710
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Application
    Filed: December 24, 2009
    Publication date: August 5, 2010
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • Process of making crystalline Type II aripiprazole
    Patent number: 7655798
    Abstract: Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated solid-solid transformation, typically in ethyl acetate.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: February 2, 2010
    Assignee: Synthon BV
    Inventors: Gerrit J. B. Ettema, Raymond J. H. Westheim, Faysal Kalmoua
  • PREGABALIN SALTS
    Publication number: 20090170945
    Abstract: Pregabalin besylate and pregabalin tosylate are pharmaceutically acceptable acid addition salts of pregabalin that are isolatable in solid state, particularly crystalline state, sufficiently soluble in water, and stable both in the solid state and in the solution.
    Type: Application
    Filed: December 19, 2008
    Publication date: July 2, 2009
    Inventor: Raymond J. H. Westheim
  • Rimonabant forms and methods of making the same
    Publication number: 20080182877
    Abstract: Various solid state forms of rimonabant have been found, including a particulate amorphous form as well as several hydrates and solvates.
    Type: Application
    Filed: December 21, 2007
    Publication date: July 31, 2008
    Inventor: Raymond J.H. Westheim
  • HYDRATES OF ERLOTINIB HYDROCHLORIDE
    Publication number: 20080167327
    Abstract: Erlotinib hydrochloride hydrate is formed from an aqueous solution and is useful as a pharmaceutical and as a purification intermediate.
    Type: Application
    Filed: October 25, 2007
    Publication date: July 10, 2008
    Inventor: Raymond J. H. Westheim
  • CRYSTALLINE FORMS OF LETROZOLE AND PROCESSES FOR MAKING THEM
    Publication number: 20070259935
    Abstract: Crystalline forms of letrozole can be made by precipitation and are useful in making pharmaceutical compositions.
    Type: Application
    Filed: May 4, 2007
    Publication date: November 8, 2007
    Inventor: Raymond J. H. Westheim
  • Ondansetron forms and processes of making the same
    Publication number: 20040198794
    Abstract: Ondansetron forms are identified and processes for making the same are provided. The ondansetron can be used in various pharmaceutical applications.
    Type: Application
    Filed: January 2, 2004
    Publication date: October 7, 2004
    Inventors: Raymond J. H. Westheim, Frans van Dalen
  • Bicalutamide forms
    Publication number: 20040063782
    Abstract: A new crystalline form of bicalutamide (form II) is disclosed. Bicalutamide form II is useful as a pharmaceutical and has antiandrogenic activity.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 1, 2004
    Inventor: Raymond J.H. Westheim